3rd Edition

Scientific Basis of the Disease and Its Management

Print ISBN: 9780128101230
eBook ISBN: 9780123972309
Imprint: Academic Press
Published Date: 16th April 2013
Page Count: 704
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Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this ancient disease, it remains a public health problem in developing countries and re-emerges in the developed world with changes in the local biodiversity. The third edition updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, vaccines, public health, immunology, and epidemiology of rabies. It provides physicians, public health advisors, epidemiologists, research scientists and veterinarians with single source, authoritative and up-to-date information on the diagnosis, treatment, control and prevention of this fatal infectious virus which continues to kill over 70,000 people a year.


Anyone involved in diagnosing, treating, controlling and preventing this disease including: physicians, public health advisors, epidemiologists, research scientists and veterinarians

Table of Contents



List of Contributors

Chapter 1. History of Rabies Research

1 Ancient Greek and Roman times

2 Girolamo Fracastoro

3 John Morgagni

4 Earliest Pathogenesis Studies

5 Louis Pasteur and Rabies Vaccination

6 Earliest Pathogenesis Studies Focused on Pathways of Neural Spread to CNS

7 Adelchi Negri and Negri bodies

8 Paul Remlinger

9 Early Studies Using Electron Microscopy

10 Fluorescent Antibody Staining by Goldwasser and Kissling

11 Pathogenesis Studies in Rodents by Richard T. Johnson and Frederick A. Murphy and Co-workers

12 First Clone of a Rabies Virus Gene


Chapter 2. Rabies Virus

1 Introduction

2 Rabies Virus Architecture

3 Genome and RNP Structures

4 Life Cycle of Rabies Virus Infection


Chapter 3. Epidemiology

1 Introduction

2 Global Epidemiology

3 Routes Of Rabies Virus Transmission

4 Risk and Prevention of Rabies Following an Exposure

5 Epidemiology of Human Rabies in North America and Europe

6 Epidemiology of Human Rabies in Africa and Asia

7 The Burden and Cost of Rabies in Africa and Asia

8 Epizootiology of Rabies in Latin America

9 Case Number Dynamics and Modeling

10 Skunk Rabies Virus Variants

11 Raccoon Rabies in North America

12 Epidemiology of Mongoose-associated Rabies

13 Canine Rabies Virus Variants

14 Conclusions


Chapter 4. Molecular Epidemiology

1 Introduction

2 Methods and Definition of Terms

3 Lyssavirus Taxonomy

4 Future Trends

5 Conclusions




Supplemental References

Chapter 5. Rabies in Terrestrial Animals

1 Introduction

2 What is a Susceptible Host?


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© Academic Press 2013
Academic Press
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"This edition includes many recent developments in the areas of epidemiology, molecular epidemiology, prevention, and treatment of human rabies, and control of wildlife and dog rabies…This book on all aspects of rabies provides worthwhile updates and is a good overall reference for scientists, students, and anyone with an interest in the prevention and control of rabies." Rating: 5 Stars --Doody.com, March 2014

"Laboratory and field specialists in rabies describe developments in understanding, preventing, and treating the disease since the second edition was published in 2007." --Reference & Research Book News, October 2013