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Quorum Sensing - 1st Edition - ISBN: 9780128149058, 9780128149065

Quorum Sensing

1st Edition

Molecular Mechanism and Biotechnological Application

Editor: Giuseppina Tommonaro
Paperback ISBN: 9780128149058
eBook ISBN: 9780128149065
Imprint: Academic Press
Published Date: 6th April 2019
Page Count: 309
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Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals.

Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists.

Key Features

  • Describes Quorum Sensing (QS) mechanisms from their molecular basis, to their clinical applications
  • Spans several fields in relation to QS, including microbiology, chemistry, biochemistry and ecology
  • Considers QS as an approach to the discovery of new antibiotics
  • Looks at QS as a means to understand the microbial world and towards use of bacteria and their products in biotechnological applications
  • Summarizes key results on QS mechanisms’ molecular basis and fields of application


Researchers in microbiology, chemistry, ecology, biochemistry including drug delivery, and food including food packaging; Suitable to researchers working in public research bodies within academia or national research councils, and private industry, including in food and pharmaceuticals

Table of Contents

1. The Chemical Language Of Gram-Negative Bacteria
2. Analytical approaches for the identification of quorum-sensing molecules
3. Quorum sensing in marine biofilms and environments
4. Quorum sensing in extremophiles

5. Quorum Sensing in Phytopathogenesis
6. Quorum sensing and gut microbiome

7. Enzymatic Quorum Quenching in Biofilms
8. Effect of Polyphenols on Microbial Cell-Cell Communications

9. Pseudomonas aeruginosa Quorum Sensing and Biofilm Inhibition

10. Cyclic Peptides in Neurological Disorders: The Case of Cyclo(His-Pro)


No. of pages:
© Academic Press 2019
6th April 2019
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editor

Giuseppina Tommonaro

Giuseppina Tommonaro, biologist, is a highly-experienced researcher based at one of Italy’s leading research institutions: The Institute of Biomolecular Chemistry, at the National Research Council. Her research activity concerns the extraction, isolation and the chemical characterization of secondary metabolites biologically active from natural source. Marine organisms, in particular sponges, plants and marine microorganisms are objects of her studies. In particular, she is involved in the isolation and characterization of natural products produced from sponge -and plant- associated microorganisms, with particular attention to metabolites involved in Quorum Sensing mechanism. Dr. Tommonaro was involved in the chemical characterization of polysaccharides and biopolymers extracted from bacteria and vegetables. During her research activity, she has developed a sound experience in the isolation and structural elucidation of natural compounds, as well as in the chemical derivation of bioactive compounds to improve the biological activity.

Affiliations and Expertise

Biologist, Institute of Biomolecular Chemistry, National Research Council of Italy

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