Quick Guide to Body Fluid Testing

Quick Guide to Body Fluid Testing

2nd Edition - November 1, 2022

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  • Authors: Darci Block, Deanna Franke
  • Paperback ISBN: 9780443185311

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Quick Guide to Body Fluid Testing, Second Edition comprehensively covers the latest updates in three parts devoted to preanalytic considerations such as collection, labeling, handling, transport, specimen pretreatment, test ordering practices, analytic validation and postanalytic considerations. This revised edition includes a new section on validation requirements when replacing instruments, expanded post-analytical considerations to include selection of quality control materials and concentrations, and expanded frequently asked questions to address questions that arise around body fluid testing. This second edition aims to help laboratories make decisions about their body fluid testing menu and risk-based decisions about the thoroughness of their validation study design, making it a valuable resource to lab professionals. This book will act as a readily available pocket reference for students, academics and health care professionals working in a wide variety of contexts in the body fluid testing process.

Key Features

  • Provides the single best resource for practical guidance to perform body fluid test validation
  • Addresses the challenging issues that laboratory professionals face day-to-day in support of body fluid testing
  • Covers didactic information that the audience can easily read, understand and reference to explain practices and processes to validate body fluid testing


Clinical pathologists, trainees of pathology and clinical chemistry residency/fellowships.
Laboratory directors of clinical testing laboratories, staff responsible for validating clinical tests and maintaining a quality program

Table of Contents

  • 1. Preanalytical Considerations
    2. Collection
    3. Labeling
    4. Handling and Transport
    5. Specimen Pretreatment
    6. Test Ordering Practices
    7. Analytic Validation
    8. Caveats for new method validation vs Instrument replacement
    9. Accuracy/Trueness for new methods
    10. Accuracy/Trueness for instrument replacement
    11. Linearity/Reportable Range
    12. Precision
    13. Analytic Sensitivity
    14. Interferences
    15. Stability
    16. Reference Intervals
    17. Postanalytic Considerations
    18. Selection of quality control material
    19. Proficiency testing practices
    20. Informatics tools for optimizing body fluid reporting

    At what temperature should body fluids be transported?
    What are the labs’ options for testing viscous samples viscosity?
    How should body fluid tests be calibrated?
    Which body fluid types and tests should be validated?
    Should I worry about body fluids “gunking up” instruments and potentially producing inaccurate results?
    How should proficiency testing be conducted?
    What is required when performing calibration verification of body fluid assays?
    Can body fluids of similar origin be pooled together to get sufficient volume for validation?
    How should quality control be conducted?
    How should we handle requests for body fluid types we haven’t validated or whose source is not specified?

Product details

  • No. of pages: 70
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: November 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780443185311

About the Authors

Darci Block

Darci Block PhD, DABCC completed her PhD in chemistry from North Dakota State University and clinical chemistry fellowship at the Mayo Clinic in 2009 and 2011, respectively. Since that time, she has been the co-medical director of the Central Clinical Laboratory at the Mayo Clinic in Rochester, USA. As it pertains to body fluid testing expertise, she has been the technical director of body fluid chemistry testing in a high volume core and reference laboratory, published in the peer reviewed literature on the subject of validating body fluid tests, authored two book chapters on the subject, developed a learning module on body fluids for the Area9 Learning Lab (AACC initiative), presented numerous times over the past 10 years at AACC through workshops and brown bag sessions on this subject, and served as vice chair for the CLSI revision of C49 Body Fluid Testing in the Clinical Chemistry Lab published in 2018

Affiliations and Expertise

Director, Department of Laboratory Medicine and Pathology, Mayo Clinic, USA

Deanna Franke

Deanna Franke MT (ASCP), Ph.D., DABCC completed her PhD in microbiology and immunology from University of Louisville and clinical chemistry and toxicology fellowship at the University of Louisville in 2005 and 2007, respectively. She is currently the Director of Technical Specialties at Atrium Health in Charlotte, NC. As it pertains to body fluid testing expertise, she served as chair for the CLSI revision of C49 Body Fluid Testing in the Clinical Chemistry Lab published in 2018, supported body fluid chemistry testing and informatics in a core laboratory, as well as presented AACC webinars and sessions.

Affiliations and Expertise

Director, Technical Specialties, Atrium Health, USA

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