Quick Guide to Body Fluid Testing

Quick Guide to Body Fluid Testing

2nd Edition - January 2, 2023

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  • Authors: Darci Block, Deanna Franke
  • Paperback ISBN: 9780443185311
  • eBook ISBN: 9780443185328

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Quick Guide to Body Fluid Testing, Second Edition comprehensively covers the latest updates in three parts devoted to preanalytic considerations such as collection, labeling, handling, transport, specimen pretreatment, test ordering practices, analytic validation and postanalytic considerations. This revised edition includes a new section on validation requirements when replacing instruments, expanded post-analytical considerations to include selection of quality control materials and concentrations, and expanded frequently asked questions to address questions that arise around body fluid testing. This second edition aims to help laboratories make decisions about their body fluid testing menu and risk-based decisions about the thoroughness of their validation study design, making it a valuable resource to lab professionals. This book will act as a readily available pocket reference for students, academics and health care professionals working in a wide variety of contexts in the body fluid testing process.

Key Features

  • Provides the single best resource for practical guidance to perform body fluid test validation
  • Addresses the challenging issues that laboratory professionals face day-to-day in support of body fluid testing
  • Covers didactic information that the audience can easily read, understand and reference to explain practices and processes to validate body fluid testing


Clinical pathologists, trainees of pathology and clinical chemistry residency/fellowships. Laboratory directors of clinical testing laboratories, staff responsible for validating clinical tests and maintaining a quality program

Table of Contents

  • Preanalytic Considerations
    - Body Fluid Test Formulary and Ordering Practices
    - Collection
    - Labeling
    - Handling and Transport
    - Specimen Assessment
    - Specimen Pretreatment
    - References
    Analytic Validation
    - Accuracy/Trueness
    - Linearity/Reportable Range
    - Precision
    - Analytic Sensitivity
    - Interferences
    - Stability
    - Reference Intervals and Medical Decision Points
    - References
    Postanalytic Considerations
    - Reporting Results
    - Quality Control Practices
    - Proficiency Testing
    - Ongoing Quality Assessments
    - Conclusion
    - References

Product details

  • No. of pages: 82
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: January 2, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780443185311
  • eBook ISBN: 9780443185328

About the Authors

Darci Block

Darci Block PhD, DABCC completed her PhD in chemistry from North Dakota State University and clinical chemistry fellowship at the Mayo Clinic in 2009 and 2011, respectively. Since that time, she has been the co-medical director of the Central Clinical Laboratory at the Mayo Clinic in Rochester, USA. As it pertains to body fluid testing expertise, she has been the technical director of body fluid chemistry testing in a high volume core and reference laboratory, published in the peer reviewed literature on the subject of validating body fluid tests, authored two book chapters on the subject, developed a learning module on body fluids for the Area9 Learning Lab (AACC initiative), presented numerous times over the past 10 years at AACC through workshops and brown bag sessions on this subject, and served as vice chair for the CLSI revision of C49 Body Fluid Testing in the Clinical Chemistry Lab published in 2018

Affiliations and Expertise

Director, Department of Laboratory Medicine and Pathology, Mayo Clinic, USA

Deanna Franke

Deanna Franke MT (ASCP), Ph.D., DABCC completed her PhD in microbiology and immunology from University of Louisville and clinical chemistry and toxicology fellowship at the University of Louisville in 2005 and 2007, respectively. She is currently the Director of Technical Specialties at Atrium Health in Charlotte, NC. As it pertains to body fluid testing expertise, she served as chair for the CLSI revision of C49 Body Fluid Testing in the Clinical Chemistry Lab published in 2018, supported body fluid chemistry testing and informatics in a core laboratory, as well as presented AACC webinars and sessions.

Affiliations and Expertise

Director, Technical Specialties, Atrium Health, USA

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