Quest for the Cure

Quest for the Cure

Reflections on the Evolution of Breast Cancer Treatment

1st Edition - October 16, 2013

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  • Author: George Blumenschein
  • eBook ISBN: 9780124202085

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This original fourteen chapter book is a brief, slightly autobiographic tale of medical oncologists, surgeons, radiation oncologists, and breast cancer patients in a well-established cancer center in Texas, who pursued the goal of cure for breast cancer. The evolution of improved outcomes in the treatment of microscopic metastatic breast cancer is also the story of the development of adjuvant chemotherapy for post-operative breast disease. The adjuvant therapy of breast cancer came about with the realization that this malignancy, when diagnosed in most patients, had spread beyond the confines of the primary cancer.

Key Features

  • Patient histories in the form of Case Studies are used to illustrate certain issues.
  • Devoted to the development of the chemotherapeutic regimens that currently are used to treat patients with advanced breast cancer.


Cancer researchers, oncologists, and cancer patient advocates

Table of Contents

    • Acknowledgments
    • Foreword
    • Preface
    • Disclaimer
    • Chapter 1. Anatomy of an Oncologist
      • 1.1 Next Stop—MDA
      • 1.2 Early Experience with 5-Fluorouracil, Adriamycin, and Cyclophosphamide
      • 1.3 Monday Night Confrontation
    • Chapter 2. Milestones Along the Road to the Cure
      • 2.1 The Importance of Patient Education
      • 2.2 Pioneers of Adjuvant Therapy
      • 2.3 Early Studies
      • 2.4 M.D. Anderson: A Pioneer in Radiation Therapy
      • 2.5 Lessons from Basic Science
    • Chapter 3. The Evolving Goal of Cure and Inflammatory Breast Cancer
      • 3.1 Understanding Treatment Strategy and the Perils of Prognostication
      • 3.2 Inflammatory Breast Cancer
      • 3.3 The Search for New Drugs to Cure IBC
      • 3.4 MCCFUD and FUMEP for IBC
      • 3.5 Taxanes
      • 3.6 Combination Chemotherapy versus Monotherapy for Consolidation Regimens
    • Chapter 4. Adjuvant Therapy Advances
      • 4.1 Prepared Minds Take on Breast Cancer
      • 4.2 Minimizing Adriamycin Cardiac Toxicity: The Most Significant Under-Utilized Clinical Observation
      • 4.3 Clinical Measurements: Predicting Prognosis
      • 4.4 Refining FAC
      • 4.5 Cisplatin Late Consolidation
    • Chapter 5. Marching Forward
      • 5.1 CALGB Study 8081
      • 5.2 Backstepping on FAC: FAC-lite
      • 5.3 Taxanes Revisited
      • 5.4 The Dose-Dense Option
      • 5.5 Slow Adoption of Consolidation Therapy
      • 5.6 The Impact of Statistical Dogmatism
    • Chapter 6. Concluding Thoughts — Where Do We Stand in the Quest for the Cure?
      • 6.1 Chemotherapeutic Principles that have Emerged
      • 6.2 Patients have an Important Role
    • Appendix 1. Milestones in Adjuvant Therapy
    • Appendix 2. Breast Cancer Stages
    • Appendix 3. Abbreviation Glossary

Product details

  • No. of pages: 108
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: October 16, 2013
  • Imprint: Academic Press
  • eBook ISBN: 9780124202085

About the Author

George Blumenschein

George Blumenschein
George R. Blumenschein, M.D. led a team of brilliant young researchers at the M.D. Anderson Cancer Center who established Adriamycin as a mainstay of contemporary breast cancer treatment regimens. This book is intended to empower interested individuals by chronicling the development and explaining the rationale underlying contemporary multimodal breast cancer therapy and by providing illustrative patient histories.

Affiliations and Expertise

Professor Emeritus, Oncology and Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, TX, USA

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