Quaternary Ammonium Salts

1st Edition

Their Use in Phase-Transfer Catalysis

Authors: R. Jones
Hardcover ISBN: 9780123891716
eBook ISBN: 9780080540153
Imprint: Academic Press
Published Date: 14th November 2000
Page Count: 565
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Table of Contents

Preface Abbreviations General Principles Simple Nucleophilic Exchange Reactions and Aromatic Substitution Reactions Formation of C--O Bonds Formation of C--S Bonds and Related Reactions Formation of C--N Bonds and Related Reactions Formation of C--C Bonds Preparation and Synthetic Applications of Carbenes Carbonylation and Other Reactions Elimination Reactions, Cleavage and Rearrangement Reactions Isomerism and H/D Exchange Reactions Oxidation of Organic Compounds Reduction of Organic Compounds Stereoselective Control in Phase-Transfer Catalyzed Reactions

Description

This text provides experimental methods for a wide range of organic reactions, systematically arranged according to reaction type, and describes the advantages and limitations of the procedures. Traditional methods to speed up organic reactions involve energy-consuming processes and costly and environmentally "unfriendly" solvents. Additionally, isolation of the product requires energy and time-consuming purification processes. A simple solution, especially for reactions involving anionic reactants, is the use of phase-transfer catalysis. Quaternary ammonium cations have the ability to transfer the anionic reactants as non-solvated ion-pairs from aqueous media into organic media. The resultant effect is to increase the rate of the organic reaction by enhancing the reactivity of the anionic species and increasing the encounter rate with the organic substrate. Side reactions are frequently eliminated so that the overall yield of the desired product is increased.

Quaternary Ammonium Salts presents procedures for reducing reaction times and the need for extreme conditions, which are frequently encountered under standard reaction procedures.

This is the only book to be published on quaternary ammonium salts. Best Synthetic Methods volumes allow the practicing synthetic chemist to choose between all the alternatives and assess their real advantages and limitations. Each volume of the series deals with a particular topic from a practical point of view, giving detailed examples and precise experimental directions and hints. With the emphasis on laboratory use, these volumes represent a comprehensive and practical guide to modern synthetic organic chemistry.

Readership

Academic and pharmaceutical industry researchers in synthetic organic chemistry.


Details

No. of pages:
565
Language:
English
Copyright:
© Academic Press 2001
Published:
Imprint:
Academic Press
eBook ISBN:
9780080540153
Hardcover ISBN:
9780123891716

Reviews

This text provides experimental methods for a wide range of organic reactions, systematically arranged according to reaction type, and describes the advantages and limitations of the procedures. Traditional methods to speed up organic reactions involve energy-consuming processes and costly and environmentally "unfriendly" solvents. Additionally, isolation of the product requires energy and time-consuming purification processes. A simple solution, especially for reactions involving anionic reactants, is the use of phase-transfer catalysis. Quaternary ammonium cations have the ability to transfer the anionic reactants as non-solvated ion-pairs from aqueous media into organic media. The resultant effect is to increase the rate of the organic reaction by enhancing the reactivity of the anionic species and increasing the encounter rate with the organic substrate. Side reactions are frequently eliminated so that the overall yield of the desired product is increased. Quaternary Ammonium Salts presents procedures for reducing reaction times and the need for extreme conditions, which are frequently encountered under standard reaction procedures. This is the only book to be published on quaternary ammonium salts. Best Synthetic Methods volumes allow the practicing synthetic chemist to choose between all the alternatives and assess their real advantages and limitations. Each volume of the series deals with a particular topic from a practical point of view, giving detailed examples and precise experimental directions and hints. With the emphasis on laboratory use, these volumes represent a comprehensive and practical guide to modern synthetic organic chemistry.


About the Authors

R. Jones Author

R. Alan Jones is a Senior Fellow at the University of East Anglia, where he held the position of Dean of the School of Chemical Sciences until 1997. He spent a period on the Faculty at the University of Adelaide, holds a Sc.D. and Ph.D. from the University of Cambridge and a degree from the University of Oxford.

Affiliations and Expertise

University of East Anglia, U.K.