Quantitative Systems Pharmacology, Volume 42

1. Introduction to Quantitative Systems Pharmacology
2. Fundamentals of quantitative pharmacology
3. Multiscale modelling, from cells to membranes, tissues, organs, and systems/body
4. Pharma vectors and drug delivery systems
5. Drug release mechanisms
6. Anatomy of mammals and specifically of humans
7. Physiology of mammals and specifically of humans
8. Role of gender, race, age, body mass/surface, genetics, diseases on organs/tissues efficiency
9. Scalability among mammals: mice, rats, cats, dogs, horses, monkeys, humans
10. Administration, distribution, metabolism, and excretion mechanisms
11. In silico, in vitro, and in vivo models/data
12. Pharmacokinetic models (compartmental and physiologically based) for different drugs and administration pathways
13. Pharmacodynamic models
14. Multiscale models of PK and PD (from cells to whole body)
15. Allometric formula for interspecies adaptation of PK/PD models
16. Personalization of treatments
17. Monitoring and control of drug administration with applied case studies
18. Design of experiments, model identification and identifiability of models
19. Applications to drug individualized treatments and surgical operations
20. Methods and models for diagnosis of diseases
21. Challenges to develop model-based systems

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more.

As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource.

• Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology
• Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy
• Discusses how drugs are driven to specific targets using nanoparticles
• Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance
• Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

Academic, government and corporate researchers in the area of quantitative pharmacology; bio-chemical engineers as well as mechanical and nuclear engineers; all involved in quantitative pharmacology such as pharmacists, biologists, chemists, and medical doctors; Mathematicians and physicists working on numerical modelling