Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord.

Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord.

Key Features

  • Chapters authored by international experts in the field of MRI of the spinal cord
  • Contains “cooking recipes”—examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice
  • Ideal for clinical settings


Neuroscience researchers and advanced students studying spinal cord physiology & pathophysiology; radiologists; clinicians (treating MS, ALS, etc)

Table of Contents

Table of Contents

Cover image

Title page






Introduction to “Quantitative MRI of the Spinal Cord”

Part I Quantitative Biomarkers in the Spinal Cord: what for?

Chapter 1.1. Rationale for Quantitative MRI of the Human Spinal Cord and Clinical Applications

1.1.1 Introduction

1.1.2 Quantitative MRI Techniques

1.1.3 Application of Quantitative MRI Techniques to Spinal Cord Disease

1.1.4 Conclusions and Future Directions

Chapter 1.2. Inflammatory Demyelinating Diseases

1.2.1 Introduction

1.2.2 Classification of Inflammatory Myelopathies

1.2.3 Transverse Myelitis: A Practical Definition Based on MRI

1.2.4 The Significance of TM and Its Relationship to MS and NMO

1.2.5 Neuromyelitis Optica: The First Demyelinating Disease with a known Serum Marker

1.2.6 MRI of the Spinal Cord: Qualitative versus Quantitative Imaging

1.2.7 Magnetization Transfer MRI Studies of the Spinal Cord

1.2.8 Diffusion-Weighted Imaging Studies in the Spinal Cord

1.2.9 MR Spectroscopy

1.2.10 Relaxometry in the Spinal Cord: T1 Mapping

1.2.11 Measurements and Significance of Spinal Cord Atrophy

1.2.12 Conclusions

Chapter 1.3A. Traumatic Spinal Cord Injury

1.3A.1 Introduction

1.3A.2 Message 1: Animal Models That Link Pathology of Acute Spinal Cord Injury to MR Signal Characteristics

1.3A.3 Message 2: Quantitative MSCC and MCC

1.3A.4 Message 3: MRI Signal Characteristics after Acute Traumatic Spinal Cord Injury: What is the Sensitivity and Specificity of Determining Neurologic Function at the Time of Injury and for Predicting Long-Term Prognosis?

1.3A.5 Conclusions

Chapter 1.3B. Traumatic Spinal Cord Injury

1.3B.1 Introduction

1.3B.2 Neurophysiology and MRI: Compleme


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© 2014
Academic Press
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About the authors

Julien Cohen-Adad

Dr. Cohen-Adad is developing advanced magnetic resonance imaging (MRI) techniques for quantitative assessment of the brain and spinal cord structure and function. These developments include hardware (coils), MRI sequences (relaxometry, diffusion tensor imaging, magnetization transfer, functional MRI) and software (multimodal registration, segmentation, motion correction, distortion correction, template creation). Between 2005 and 2008 he did his PhD at Université de Montréal (Canada) and Pitié-Salpétrière Hospital (Paris, France), during which he translated research protocols to clinics for the quantitative evaluation of chronic spinal cord injury and amyotrophic lateral sclerosis patients. Between 2009 and 2012, he did his postdoctoral fellowship at the MGH Martinos Center at Harvard University, aiming to further his expertise in Ultra-High Field MRI technology (7 Tesla) and coil building. Since his faculty appointment at Polytechnique Montreal in 2012, he has been pursuing these developments while setting up a lab environment for transferring knowledge to the local community.


" exciting addition to the scientific knowledge about spinal imaging...a jumping off point for future research into the use of quantitative techniques in the spinal cord. Score: 100 - 5 Stars!"--Doody's