Quantitative MRI of the Spinal Cord

1st Edition

Print ISBN: 9780123969736
eBook ISBN: 9780123972828
Imprint: Academic Press
Published Date: 15th March 2014
Page Count: 330
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Quantitative MRI of the Spinal Cord is the first book focused on quantitative MRI techniques with specific application to the human spinal cord. This work includes coverage of diffusion-weighted imaging, magnetization transfer imaging, relaxometry, functional MRI, and spectroscopy. Although these methods have been successfully used in the brain for the past 20 years, their application in the spinal cord remains problematic due to important acquisition challenges (such as small cross-sectional size, motion, and susceptibility artifacts). To date, there is no consensus on how to apply these techniques; this book reviews and synthesizes state-of-the-art methods so users can successfully apply them to the spinal cord.

Quantitative MRI of the Spinal Cord introduces the theory behind each quantitative technique, reviews each theory’s applications in the human spinal cord and describes its pros and cons, and suggests a simple protocol for applying each quantitative technique to the spinal cord.

Key Features

  • Chapters authored by international experts in the field of MRI of the spinal cord
  • Contains “cooking recipes”—examples of imaging parameters for each quantitative technique—designed to aid researchers and clinicians in using them in practice
  • Ideal for clinical settings


Neuroscience researchers and advanced students studying spinal cord physiology & pathophysiology; radiologists; clinicians (treating MS, ALS, etc)

Table of Contents

Table of Contents

Cover image

Title page






Introduction to “Quantitative MRI of the Spinal Cord”

Part I Quantitative Biomarkers in the Spinal Cord: what for?

Chapter 1.1. Rationale for Quantitative MRI of the Human Spinal Cord and Clinical Applications

1.1.1 Introduction

1.1.2 Quantitative MRI Techniques

1.1.3 Application of Quantitative MRI Techniques to Spinal Cord Disease

1.1.4 Conclusions and Future Directions

Chapter 1.2. Inflammatory Demyelinating Diseases

1.2.1 Introduction

1.2.2 Classification of Inflammatory Myelopathies

1.2.3 Transverse Myelitis: A Practical Definition Based on MRI

1.2.4 The Significance of TM and Its Relationship to MS and NMO

1.2.5 Neuromyelitis Optica: The First Demyelinating Disease with a known Serum Marker

1.2.6 MRI of the Spinal Cord: Qualitative versus Quantitative Imaging

1.2.7 Magnetization Transfer MRI Studies of the Spinal Cord

1.2.8 Diffusion-Weighted Imaging Studies in the Spinal Cord

1.2.9 MR Spectroscopy

1.2.10 Relaxometry in the Spinal Cord: T1 Mapping

1.2.11 Measurements and Significance of Spinal Cord Atrophy

1.2.12 Conclusions

Chapter 1.3A. Traumatic Spinal Cord Injury

1.3A.1 Introduction

1.3A.2 Message 1: Animal Models That Link Pathology of Acute Spinal Cord Injury to MR Signal Characteristics

1.3A.3 Message 2: Quantitative MSCC and MCC

1.3A.4 Message 3: MRI Signal Characteristics after Acute Traumatic Spinal Cord Injury: What is the Sensitivity and Specificity of Determining Neurologic Function at the Time of Injury and for Predicting Long-Term Prognosis?

1.3A.5 Conclusions

Chapter 1.3B. Traumatic Spinal Cord Injury

1.3B.1 Introduction

1.3B.2 Neurophysiology and MRI: Compleme


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© Academic Press 2014
Academic Press
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"...an exciting addition to the scientific knowledge about spinal imaging...a jumping off point for future research into the use of quantitative techniques in the spinal cord. Score: 100 - 5 Stars!"--Doody's