Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
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Quadruplex Nucleic Acids As Targets For Medicinal Chemistry

1st Edition - August 25, 2020

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  • Editor: Stephen Neidle
  • eBook ISBN: 9780128210185
  • Hardcover ISBN: 9780128210178

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Description

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Annual Reports in Medicinal Chemistry series

Readership

Undergraduates, graduates, academics and researchers in the field of medicinal chemistry

Table of Contents

  • Part 1. Fundamentals of quadruplexes and their biology

      1. Fundamentals of G-quadruplex biology

        2.

        F. Brad Johnson

      2. Quadruplex structure and diversity

        3.

        Fernaldo Richtia Winnerdy and Anh Tuân Phan

        Part 2. Quadruplex targets in human and other organisms

      3. Telomeric quadruplexes as therapeutic targets

        4.

        Sefan Asamitsu, Norifumi Shioda and Hiroshi Sugiyama

      4. Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy

        5.

        Emanuela Ruggiero and Sara N. Richter

      5. Quadruplex detection in human cells

        6.

        David Monchaud

        Part 3. Discovery and design of quadruplex-binding compounds

      6. An overview of quadruplex ligands: Their common features and chemotype diversity

        7. Valentina Pirota, Michele Stasi, Alessandra Benassi and Filippo Doria

      7. Molecular dynamics simulations of G-quadruplexes: The basic principles and their application to folding and ligand binding

        8.

        Jiri Sponer, Barira Islam, Petr Stadlbauer and Shozeb Haider

      8. Quadruplex-interacting compounds for regulating the translation of the Epstein–Barr virus nuclear antigen 1 (EBNA1) mRNA: A new strategy to prevent and treat EBV-related cancers

        9.

        Anton Granzhan, Rodrigo Prado Martins, Robin Fåhraeus, Marc Blondel and Marie-Paule Teulade-Fichou

      9. Click and combinatorial approaches to quadruplex ligand discovery

        10.

        Jyotirmayee Dash, Puja Saha and Khushnood Fatma

      10. Quadruplex nucleic acids in KRAS targeted-cancer therapy

        11.

        Luigi E. Xodo

      11. Transcriptional regulation of MYC through G-quadruplex structures

        12.

        Sumirtha Balaratnam and John S. Schneekloth

      12. KIT promoter: Structure, function and targeting

        13.

        Silvia Ceschi and Claudia Sissi

      13. Quadruplex targets in neurodegenerative diseases

        14.

        Janez Plavec

      14. Metal complexes as G-quadruplex binders

        15.

        Tim Kench and Ramon Vilar

      15. Challenges in developing small-molecule quadruplex therapeutics

    Stephen Neidle

Product details

  • No. of pages: 564
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: August 25, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128210185
  • Hardcover ISBN: 9780128210178

About the Serial Editor

Stephen Neidle

Stephen Neidle
Stephen Neidle is an Emeritus Professor of Chemical Biology at University College London, where he has also been the Director of Research in the School of Pharmacy. He has published over 500 primary papers and reviews and is a principal inventor on 14 patent filings. He has also written and edited several books on nucleic acids and anti-cancer drugs.

Affiliations and Expertise

Emeritus Professor of Chemical Biology, The School of Pharmacy, University College London, UK

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