Pulmonary Endocrine Pathology - 1st Edition - ISBN: 9780750614405, 9781483193830

Pulmonary Endocrine Pathology

1st Edition

Endocrine Cells and Endocrine Tumours of the Lung

eBook ISBN: 9781483193830
Imprint: Butterworth-Heinemann
Published Date: 6th May 1992
Page Count: 192
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Pulmonary Endocrine Pathology: Endocrine Cells and Endocrine Tumours of the Lung covers basic principles and concepts of pulmonary endocrinology and the anatomy, physiology and pathology of that part of the diffuse endocrine system which populates the pulmonary epithelium. The book provides a brief review of some basic principles of endocrinology and of the concept and nature of the diffuse endocrine system. The text describes the structure, physiology, and role in and reaction to natural disease; and experimental injury of the pulmonary component; and the morphology and content of endocrine cells in normal lungs.
The development and distribution of the pulmonary endocrine system and how it alters from fetal to adult life are also reviewed. The book further tackles the physiology of the pulmonary endocrine system; the pulmonary endocrine system in diseased lungs and in experimental injury; and the endocrinology of bronchial neoplasms. The book then looks into the pathology of endocrine tumors of the lung, with particular emphasis on their morphology and differential diagnosis; serum markers of pulmonary endocrine neoplasms; and paraneoplastic manifestations of pulmonary endocrine neoplasms. Pathologists, physicians or surgeons who work in the fields of pulmonology, endocrinology or oncology will find the book useful.

Table of Contents


1 Introduction

The Lung as an Endocrine Organ

Systems of Control of Homeostasis and their Integration

Types of Secretion

The Concept and Nature of the Diffuse Endocrine System

The Pulmonary Component of the System

2 Identification, Morphology and Secretory Products of the Pulmonary Endocrine System



Morphology, Solitary Cells and Clusters, Neuroepithelial Bodies


Established and Possible Secretory Products

3 Development and Distribution of the Pulmonary Endocrine System


Methods of Quantisation


Development and Distribution in Fetal, Postnatal and Adult Lungs

Pattern of Change with Ageing

4 Physiology of the Pulmonary Endocrine System

General Views of the Functions of the System

Nature and Roles of its Secretory Products

Bombesin-Like Peptides, Calcitonin, Calcitonin Gene-Related Peptide and Serotonin

Pulmonary Endocrine Cells as Receptors, their Response to Hypoxia and its Consequences

Pulmonary Endocrine Cells as Paracrine Regulators, their Possible Roles

5 The pulmonary Endocrine System in Diseased Lungs

Response of the System to Pulmonary Disease

Inflammatory and Fibrotic Disorders of the Lungs

Asthma, Chronic Bronchitis and Emphysema, Pneumonia, Bronchiectasis and Cystic Fibrosis

The Nature and Characteristics of Pulmonary Tumourlets

Pulmonary Peptides in the Serum, Aberrant Secretion

Neonatal Pulmonary Disease and Sudden Infant Death

Hypertensive Pulmonary Vascular Disease

Explaining the Response, Patterns of Proliferation and Functional Changes

6 The Pulmonary Endocrine System in Experimental Injury

Hypercapnia, Hyperoxia, Ozone and other Gases

Particulate Material, Asbestos and Silica

Response of the System to Carcinogenic Hydrocarbons

Experimental Induction of Pulmonary Endocrine Tumours

Nicotine and Cigarette Smoke

Polluted Urban Air


7 Endocrine Differentiation in Pulmonary Neoplasms

Range and Classification of Pulmonary Neoplasms and of Pulmonary Neoplasms Showing Endocrine Differentiation

Nature of Pulmonary Endocrine Neoplasms and the Concept of an 'Endocrine Spectrum'

Carcinoid Tumours, Atypical Carcinoid Tumours and Small Cell Carcinoma and its Sub-Types

Manifestations of Endocrine Differentiation, its Detection in Pulmonary Tumours and its Implications

8 Pathology of Pulmonary Endocrine Neoplasms

Pathology of Carcinoid Tumours, Central and Peripheral Lesions

Pathology of Atypical Carcinoid Tumours

Pathology of Small Cell Carcinoma

Small Cell Carcinoma in Culture, Classical and Variant Lines

Genetic Pathology of Small Cell Carcinoma

Autotrophic Influences on Small Cell Carcinoma

Differential Diagnosis of Pulmonary Endocrine Tumours

Endocrine Tumours and Pulmonary Tumourlets

9 Serum Markers of Pulmonary Endocrine Neoplasms

Oncofetal Antigens, Placental Proteins, Enzymes and other Non-Specific Tumour Markers

Neuron-Specific Enolase, Creatine Kinase, Chromogranins/Secretogranins and other 'Endocrine' Markers

Secretory Products, Peptides and Amines, 'Ectopic', 'Inappropriate' or 'Aberrant' Secretion

Adrenocorticotrophin and Related Peptides

Calcitonin and Calcitonin Gene-Related Peptide

Arginine Vasopressin and the Neurophysins

Bombesin-Like Peptides

Growth Hormone and Associated Peptides

Utility of Serum Markers in Management of Disease

10 Paraneoplastic Manifestations of Pulmonary Endocrine Neoplasms

Nature of Paraneoplastic Phenomena

Mechanisms of Paraneoplasia, Secretory Products and Immune Mechanisms

Endocrine Phenomena

The Carcinoid Syndrome

Adrenocorticotrophin and Cushing's Syndrome

Inappropriate Secretion of Arginine Vasopressin Gynaecomastia

Cutaneous Changes

Epidermal Proliferations, Erythematous and Blistering Disorders, Hypertrichosis and Dermatomyositis

Osteoarticular Phenomena

Digital Clubbing and Hypertrophic Osteoarthropathy

Neurological Phenomena

The Cerebrum, Cerebellum and Eye

The Spinal Cord and Peripheral Nerves

Autonomie Eeffects

Effects on the Myoneural Junction, the Lambert-Eaton Syndrome



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