Psychopharmacological Agents

Psychopharmacological Agents

1st Edition - January 1, 1967

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  • Editor: Maxwell Gordon
  • eBook ISBN: 9781483274461

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Psychopharmacological Agents, Volume II, provides an overview of the state of knowledge in psychopharmacological agents. The organization of this book is generally based on a treatment of the major classes of psychopharmacological agents in separate chapters. To the extent allowed by the diverse nature of the subject matter, each chapter covers the history, synthesis, pharmacological activity, in vivo distribution and metabolic fate, analytical methods, and, briefly, the clinical uses of each class of psychopharmacological agents. This volume includes a chapter on the butyrophenones, one on miscellaneous psychopharmacological agents, and one on the biochemical basis of mental disease. The last named chapter is not exhaustive, but is merely meant to be illustrative of the currents of research that one finds in this field. The appendices have been used as a vehicle for collecting part of the part of the flood of reports that could not be included in either of the two volumes. Although written primarily for medicinal chemists and pharmacologists, researchers in other disciplines such as clinical investigation, biochemistry, analytical chemistry, etc., may also find material of interest here.

Table of Contents

  • List of Contributors


    Preface to Volume I

    Preface to Volume II

    Contents of Volume I

    1. Phenothiazines

    I. Introduction

    II. Synthesis of the Phenothiazines

    III. Some Procedures for the Pharmacological Evaluation of Psychopharmacological Agents

    IV. Pharmacology of Ghlorpromazine

    V. Structure-Activity Relationships in the Phenothiazines

    VI. In Vivo Distribution and Metabolism of Phenothiazines

    VII. Analytical Methods for Phenothiazines

    VIII. Miscellaneous Properties of Phenothiazines

    IX. Summary of Clinical Applications


    2. Haloperidol and Related Butyrophenones

    I. Origin

    II. Structure-Activity Relationships

    III. Pharmacological Activity of the Butyrophenones

    IV. Clinical Uses


    3. Biochemical Basis of Mental Disease

    I. Introduction

    II. Theories of Mental Disease


    4. Miscellaneous Psychotherapeutic Agents



    Appendix A. Phenothiazine Bibliographies

    A.l Acetophenazine

    A.2 Carphenazine

    A.3 Fluphenazine

    A.4 Mepazine

    A.5 Methdilazone

    A.6 Methoxypromazine

    A.7 Perphenazine

    A.8 Pipamazine

    A.9 Prochlorperazine

    A.10 Promazine

    A.11 Propiomazine

    A.12 Prothipendyl

    A.13 Thiethylperazine

    A.14 Thiopropazate

    A.15 Thioridazine

    A.16 Trifluoperazine

    A.17 Triflupromazine

    A. 18 Trimeprazine

    Appendix B. Meprobamate-like Agents Bibliographies

    B.l Phenaglycodol

    B.2 Mephenoxalone

    B.3 Promoxalone

    B.4 Emylcamate

    B.5 Hydroxyphenamate

    B.6 Phenylpropanolcarbamate

    B.7 Metaxalone

    B.8 Methocarbamol

    B.9 Oxanamide

    B.10 Ectylurea

    B.ll Methyprylone

    B.l2 Ethchlorvynol

    Appendix C. Addenda to Volume I

    C.l Chlorprothixene

    C.2 Clinical Applications of the Monoamine Oxidase Inhibitors (Hydrazines): Addendum

    I. Mental Depression

    II. Angina Pectoris

    III. Hypertension

    IV. Epilepsy


    VI. Side Effects and Toxicity


    C.3 Biochemistry and Pharmacology of the Monoamine Oxidase Inhibitors (Plydrazines): Addendum

    I. Biochemical Properties of MAO and MAO Inhibitors

    II. Factors Influencing MAO Inhibitors

    III. MAO Inhibitors and Tissue Amines

    IV. Other Biochemical Actions of the Hydrazine Inhibitors

    V. Pharmacological Properties of MAO Inhibitors

    VI. Interaction of MAO Inhibitors with Other Substances

    VII. Miscellaneous Actions


    Author Index

    Subject Index

Product details

  • No. of pages: 640
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483274461

About the Editor

Maxwell Gordon

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