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Psychopharmacological Agents - 1st Edition - ISBN: 9781483230269, 9781483274461

Psychopharmacological Agents

1st Edition

Editor: Maxwell Gordon
eBook ISBN: 9781483274461
Imprint: Academic Press
Published Date: 1st January 1967
Page Count: 640
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Psychopharmacological Agents, Volume II, provides an overview of the state of knowledge in psychopharmacological agents. The organization of this book is generally based on a treatment of the major classes of psychopharmacological agents in separate chapters. To the extent allowed by the diverse nature of the subject matter, each chapter covers the history, synthesis, pharmacological activity, in vivo distribution and metabolic fate, analytical methods, and, briefly, the clinical uses of each class of psychopharmacological agents.
This volume includes a chapter on the butyrophenones, one on miscellaneous psychopharmacological agents, and one on the biochemical basis of mental disease. The last named chapter is not exhaustive, but is merely meant to be illustrative of the currents of research that one finds in this field. The appendices have been used as a vehicle for collecting part of the part of the flood of reports that could not be included in either of the two volumes. Although written primarily for medicinal chemists and pharmacologists, researchers in other disciplines such as clinical investigation, biochemistry, analytical chemistry, etc., may also find material of interest here.

Table of Contents

List of Contributors


Preface to Volume I

Preface to Volume II

Contents of Volume I

1. Phenothiazines

I. Introduction

II. Synthesis of the Phenothiazines

III. Some Procedures for the Pharmacological Evaluation of Psychopharmacological Agents

IV. Pharmacology of Ghlorpromazine

V. Structure-Activity Relationships in the Phenothiazines

VI. In Vivo Distribution and Metabolism of Phenothiazines

VII. Analytical Methods for Phenothiazines

VIII. Miscellaneous Properties of Phenothiazines

IX. Summary of Clinical Applications


2. Haloperidol and Related Butyrophenones

I. Origin

II. Structure-Activity Relationships

III. Pharmacological Activity of the Butyrophenones

IV. Clinical Uses


3. Biochemical Basis of Mental Disease

I. Introduction

II. Theories of Mental Disease


4. Miscellaneous Psychotherapeutic Agents



Appendix A. Phenothiazine Bibliographies

A.l Acetophenazine

A.2 Carphenazine

A.3 Fluphenazine

A.4 Mepazine

A.5 Methdilazone

A.6 Methoxypromazine

A.7 Perphenazine

A.8 Pipamazine

A.9 Prochlorperazine

A.10 Promazine

A.11 Propiomazine

A.12 Prothipendyl

A.13 Thiethylperazine

A.14 Thiopropazate

A.15 Thioridazine

A.16 Trifluoperazine

A.17 Triflupromazine

A. 18 Trimeprazine

Appendix B. Meprobamate-like Agents Bibliographies

B.l Phenaglycodol

B.2 Mephenoxalone

B.3 Promoxalone

B.4 Emylcamate

B.5 Hydroxyphenamate

B.6 Phenylpropanolcarbamate

B.7 Metaxalone

B.8 Methocarbamol

B.9 Oxanamide

B.10 Ectylurea

B.ll Methyprylone

B.l2 Ethchlorvynol

Appendix C. Addenda to Volume I

C.l Chlorprothixene

C.2 Clinical Applications of the Monoamine Oxidase Inhibitors (Hydrazines): Addendum

I. Mental Depression

II. Angina Pectoris

III. Hypertension

IV. Epilepsy


VI. Side Effects and Toxicity


C.3 Biochemistry and Pharmacology of the Monoamine Oxidase Inhibitors (Plydrazines): Addendum

I. Biochemical Properties of MAO and MAO Inhibitors

II. Factors Influencing MAO Inhibitors

III. MAO Inhibitors and Tissue Amines

IV. Other Biochemical Actions of the Hydrazine Inhibitors

V. Pharmacological Properties of MAO Inhibitors

VI. Interaction of MAO Inhibitors with Other Substances

VII. Miscellaneous Actions


Author Index

Subject Index


No. of pages:
© Academic Press 1967
1st January 1967
Academic Press
eBook ISBN:

About the Editor

Maxwell Gordon

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