Protides of the Biological Fluids

1st Edition

Proceedings of the Thirty-Fifth Colloquium, 1987

Editors: H. Peeters
Hardcover ISBN: 9780080355887
eBook ISBN: 9781483148380
Imprint: Pergamon
Published Date: 1st January 1987
Page Count: 556
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Protides of the Biological Fluids examines protides of the biological fluids and covers topics ranging from the use of DNA probes to diagnose inherited diseases and receptors to the conformation and function of biologically active peptides. This text has 115 chapters and begins by demonstrating the existence of gene families common to several vertebrates and which evolved by intragenic duplication. The chapters that follow focus on the use of DNA probes in the analysis of inherited disorders such as thalassemia and hemophilia. The reader is then introduced to receptors, especially for peptides. Receptors on circulating cells, hormone receptors, receptors involved in cancer, and immunoglobulin receptors are explored. The section on the conformation and function of biologically active peptides considers the methods including spectroscopic methods, crystallography, and theoretical conformational analysis. In particular, the use of synchrotron X-radiation in biological crystallography and of 2D NMR spectroscopy in the identification of folded structures in immunogenic peptides is highlighted. This book will be of value to biologists and biochemists.

Table of Contents

Preface Acknowledgments The Sixteenth Arne Tiselius Memorial Lecture Expression of Genes Encoding the Vitamin D Binding Protein and Transferrin Section A. DNA Probes For Inherited Diseases A.1. Thalassemia Diagnosis of Thalassemia by DNA Analysis A.2. Haemophilia and X-Linked Diseases First Trimester Prenatal Diagnosis of Hemophilia A by Combined Use of DNA Probes Carrier Detection and Genetic Counselling in Hemophilia Using DNA Probes The Identification of Haemophilia B Mutations Gene Defects in Haemophilia A and B Carrier Detection Using DNA Analysis in French Families of Haemophilia A and B Studies on the Molecular Basis of Steroid Sulphatase Deficiency in Man Mitotic-Origin of a Duchenne Muscular Dystrophy Mutation A.3. Unknown Genes Progress Towards Cloning of the Cystic Fibrosis Gene—Identification of New DNA Markers in the 7Q31 Region DNA Marker Analysis of Danish Polycystic Kidney Disease Families Information Given by the 3' HVR α-Globin Marker in Ten French Families with Adult Polycystic Kidney Disease Use of a Genetic Marker for the Diagnosis of Adult Polycystic Kidney Disease in Northern Italy Construction of Lambda gt 11 cDNA Libraries from Post-Mortem Human Brains Genetic Analysis of Human T-Cell Antigens. I. Cytogenetic and Phenotypic Characterization of Interspecies T-Cell Lines Genetic Analysis of Human T-Cell Antigens. II. Mapping of the Human Chromosomes Involved in the Expression of T10 T-Cell Antigen A.4. Multifactorial Diseases Genetic Approach to the Study of Multifactorial Diseases Restriction Fragment Length Polymorphisms in the Apolipoprotein E-C1-C2 Gene Cluster: Association with Familial Dysbetalipoproteinemia The Involvement of Apolipoprotein B Gene Variants in the Determination of Serum Cholesterol Levels


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© Pergamon 1987
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About the Editor

H. Peeters