Protides of the Biological Fluids
Proceedings of the Thirty-Fifth Colloquium, 1987
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Protides of the Biological Fluids examines protides of the biological fluids and covers topics ranging from the use of DNA probes to diagnose inherited diseases and receptors to the conformation and function of biologically active peptides. This text has 115 chapters and begins by demonstrating the existence of gene families common to several vertebrates and which evolved by intragenic duplication. The chapters that follow focus on the use of DNA probes in the analysis of inherited disorders such as thalassemia and hemophilia. The reader is then introduced to receptors, especially for peptides. Receptors on circulating cells, hormone receptors, receptors involved in cancer, and immunoglobulin receptors are explored. The section on the conformation and function of biologically active peptides considers the methods including spectroscopic methods, crystallography, and theoretical conformational analysis. In particular, the use of synchrotron X-radiation in biological crystallography and of 2D NMR spectroscopy in the identification of folded structures in immunogenic peptides is highlighted. This book will be of value to biologists and biochemists.
Table of Contents
Preface
Acknowledgments
The Sixteenth Arne Tiselius Memorial Lecture
Expression of Genes Encoding the Vitamin D Binding Protein and Transferrin
Section A. DNA Probes For Inherited Diseases
A.1. Thalassemia
Diagnosis of Thalassemia by DNA Analysis
A.2. Haemophilia and X-Linked Diseases
First Trimester Prenatal Diagnosis of Hemophilia A by Combined Use of DNA Probes
Carrier Detection and Genetic Counselling in Hemophilia Using DNA Probes
The Identification of Haemophilia B Mutations
Gene Defects in Haemophilia A and B
Carrier Detection Using DNA Analysis in French Families of Haemophilia A and B
Studies on the Molecular Basis of Steroid Sulphatase Deficiency in Man
Mitotic-Origin of a Duchenne Muscular Dystrophy Mutation
A.3. Unknown Genes
Progress Towards Cloning of the Cystic Fibrosis Gene—Identification of New DNA Markers in the 7Q31 Region
DNA Marker Analysis of Danish Polycystic Kidney Disease Families
Information Given by the 3' HVR α-Globin Marker in Ten French Families with Adult Polycystic Kidney Disease
Use of a Genetic Marker for the Diagnosis of Adult Polycystic Kidney Disease in Northern Italy
Construction of Lambda gt 11 cDNA Libraries from Post-Mortem Human Brains
Genetic Analysis of Human T-Cell Antigens. I. Cytogenetic and Phenotypic Characterization of Interspecies T-Cell Lines
Genetic Analysis of Human T-Cell Antigens. II. Mapping of the Human Chromosomes Involved in the Expression of T10 T-Cell Antigen
A.4. Multifactorial Diseases
Genetic Approach to the Study of Multifactorial Diseases
Restriction Fragment Length Polymorphisms in the Apolipoprotein E-C1-C2 Gene Cluster: Association with Familial Dysbetalipoproteinemia
The Involvement of Apolipoprotein B Gene Variants in the Determination of Serum Cholesterol Levels
The Relevance of the Use of Synthetic Oligonucleotides for Apolipoprotein E (apoE) Mutants for Clinical Diagnosis of Hyperlipoproteinemia Type III
DNA Markers Linked to Diabetes
HLA Class II Region α Chain Polymorphism and the Genetic Susceptibility to Insulin Dependent (Type 1) Diabetes Mellitus and Coeliac Disease
A.5. Other Proteins and Amino-Acids
Correlation Between Polymorphic DNA Haplotypes at the Phenylalanine Hydroxylase Locus and Clinical Phenotypes of Phenylketonuria
Genetic Variants of Serum Albumin and Polymorphism of the Albumin Gene
Identification of Carriers of Mutant Prealbumin Gene Associated with Familial Amyloidotic Polyneuropathy Type I: Study of One Portuguese Pedigree
Synthesis of Serum Amyloid A by Murine Hepatocytes and of Amyloid-Related Protein(s) by Murine Peritoneal Macrophages
Unique DNA Polymorphisms Associated with the Alpha1-Antitrypsin (PI) Z Deficiency Allele: Application to Prenatal Diagnosis
High Frequency of Arginine 47 Mutation in Antithrombin III Hereditary Deficiencies Affecting the Heparin Binding Site
Studies of DNA Polymorphisms in Collagen Genes in Health and Disease
Isolation and Characterization of a cDNA Clone for Human Alpha2-HS Glycoprotein
Section B. Receptors
B.1. Neuropeptide Receptors
Further Characterization of Two 3H-Neurotensin Binding Sites in Rat Brain
Biochemical and Cellular Characterisation of Multiple Tachykinin Receptors
Regulation of μ-Opiate Receptors in Cultured Neurons
3H-Lofentanil Binding to Opiate Receptors in Human Cerebellum
Distribution in the Brain and Spinal Cord (Rat and Human) of Enkephalin Targets (μ, δ Opioid Receptors and Enkephalinase) in Various Physiopathological Conditions
Cholecystokinin (CCK) Receptors and Immunoreactivity in the Rat Brain: Functional Significance of Subregional Distributions
Modulation of Intracranial Self Stimulation by Cholecystokinin Depends on the Site of Administration
Modulation of Natural Killer (NK) Cell Activity by Met-Enkephalin in Culture
Autoradiographic Localization of CCK Binding Sites in the Human Brain
Characterization of Substance P (1-7) Generating Enzyme in Human Choroid Plexus
Solubilisation of the Muscarinic Receptor in CHAPSO: A Comparison with the Receptor in Membranes and in Digitonin Solution
Anti-Idiotypic Antibodies that Bind Cholinergic Ligands Isolated from a Myasthenia Gravis Patient
Cellular Response to Acetylcholine Receptor in Myasthenia Gravis
Degradation of Leu- and Met-Enkephalin and their C-Terminal Extensions by Tripeptidyl Peptidase II
B.2. Receptors on Circulating Cells
Structure and Function of GPIb, The Principal Platelet Von Willebrand Receptor
Secretion of ir-ACTH by Cells of Lymphoid Origin: Detection at the Single Cell Level
Cytotoxic Activity of Lymphocyte Clones from Aged People
Proliferative Capacity of Lymphocyte Clones from Old Subjects
Modulation of Target Molecules by γ-Interferon: Susceptibility of Lysis by NK Cells
Laminin Production by Natural Killer Cells
Agonist Function of Anti-CD2 and Anti-CD16 Monoclonal Antibodies on Human NK Killing
Flow Cytometric Evaluation of Natural Killer Cytotoxicity
Freeze-Fracture Ultrastructure of the Binding Between NK Lymphocyte and K562 Target Cells
The Low-Affinity Fc Receptor for IgG Recognized by MOAB AB8.28 is Capable of Transducing Activation and Degranulatory Signals in Large Granular Lymphocytes
Binding of C-Reactive Protein and Related Peptides to Neutrophils
The Phosphatidylinositol-Specific Phospholiphase C (PLC) in Rat Neutrophils (PMN)
Subcellular Localization of Mac-1 (CR3) in the Human Neutrophil
Polymorphonuclear Cell Fc-Gamma Receptors in Rheumatoid Arthritis
Formylpeptide Induced Neutrophil Chemotaxis Inhibition by Atropine and Phentolamine
Receptors for Tuftsin on Plasma Membranes of Macrophages and Macrophage Hybridoma Cell Lines
Analysis of Cell Mediated Immune Response by Using Interspecies Hybrid Lines as Stimulator
The Purification of Human α1-T Glycoprotein from Serum and its Clinical Application
Role of Fibronectin in the Function of Neutrophils
B.3. Hormone Receptors
Studies on Growth Hormone Receptors
Characterization of the Somatogenic Receptor in Rat Liver
Characterization of Rat Liver Prolactin Receptor
Characterization of Angiotensin Receptors from Human Kidney
Insulin Binding on Erythrocytes is Increased by Albumin-Associated Plasma Modulators
Insulin Like Growth Factor 1 Receptor on Isolated Lymphocytes as a Basis for Studies of IGF-1 Receptors on Mitogen-Stimulated-Lymphocytes and Lymphatic Cells
Which Method for "Microalbuminuria" In Diabetes Mellitus?
B.4. Receptors in Cancer
Heterogeneity of Oestrogen Receptors in Human Breast Tumors
Clinical Significance of Abnormal Oestrogen Receptors in Breast and Gynaecological Cancers
Are Epidermal Growth Factor Receptors Present in the Human Prostate
Antiproteasic Peptides in Human Cancer: A Host Reaction or an Autonomic Secretion
Biological Expression of Proteinase Inhibitors Pattern in Human Cancer. The Clinical Potential Utility
Secretion of Two Different Types of Growth Factors by the HT-29 Human Colonic Adenocarcinoma Cell Line
Fibroblast Aromatase: A New System for Investigating the Mechanisms of Action of Vitamin D Metabolites on Cellular Differentiation
Comparison of Prostate Specific Antigen and Prostatic Acid Phosphatase in the Detection of Prostatic Cancer
Behavior of Serum Antiproteasic Enzymes in Relation with Chemotherapy Regimens
Effect of Tumor's Metastatic Potential and Growth Rate on Tumor/Host Relationship
The Utilization of Monoclonal Antibodies to Detect Alterations in Leukocytic Subset Ratios Following Chemotherapy
Effect of Tumor Necrosis Factor on a Prostate Tumor Model
Evaluation of Adriamycin Chemotherapy and Polyamine Synthesis Inhibitor Alpha-difluoromethylornithine (DFMO) in the Treatment of a Transplantable Prostate Carcinoma of the Rat
B.5. Immunoglobulin Receptors
Serum Levels of Free and Ligand-Bound Receptor for Polymeric Immunoglobulins in Bile Duct-Ligated Rats
Immunoglobulin (IG) Receptors of Renal Tubule: Subcellular Localization and Characterization
A Monoclonal Antibody Interacting with Human Fcγ Receptor
Human Fcγ Epitopes and Interaction Sites for Effector Molecules
Occurrence of Damaged Heavy Chains During Purification of Murine IgE Antibodies by Fast Protein Liquid Chromatography (FPLC) and Their Effect on the Determination of Concentration and Affinity in ELISA
B.6. Biomatrix
Cooperation of Kupffer Cells and Perisinusoidal Lipocytes in the Production of Liver Biomatrix Components: Mediators of Kupffer Cells Stimulate Proliferation and Proteoglycan Synthesis of Lipocytes
Interactions of Free Glycosaminoglycan Chains and of Native Proteoglycans Secreted by Rat Liver Fat Storing Cells with Hepatocytic Surfaces
Epithelial Cell Surface Proteoglycan: A Matrix Receptor for Interstitial Collagens and Fibronectin
Properties of High and Low Molecular Weight Phosphomannose Receptors from Bovine Liver and Testis
Fibrinogen Binding on Candida albicans Germ Tubes and Mycelium
Receptor-Mediated Uptake of B-Glucuronidase into Glial Cells from Rat Brain
Cell Fusion in Electric Field in the Production of Monoclonal Antibodies Against Soluble and Cellular Polypeptide Antigens
Type IX and Type XII Collagens: A New Class of Extracellular Matrix Components
B.7. Other Receptors
The Use of Specific Antisera to Study the Developmental Regulation of Guanine Nucleotide Binding Proteins
Identification of Bradykinin Receptors on NG108-15 Hybrid Cells
Section C. Conformation And Function Of Biologically Active Peptides
C.1. Molecular Graphics
The Use of Molecular Graphics in the Design of Inhibitors of Zinc Proteases
New Techniques for the Exploration of Molecular Energy Surfaces and their Application to Dermorphin
C.2. NMR Studies
Two-Dimensional Exchange Experiments in NMR Studies of Protein Dynamics and Folding
Properties of the Protein Solvent Interface, Studied by Deuterium Exchange in Basic Pancreatic Trypsin Inhibitor
A Comparative Molecular Structural Study of the Third Component of Complement and Alpha-2-Macroglobulin: Structures of the Peptide Segments that are Susceptible to the Attack by Endoproteinases
Dynamics of Elastase Peptide Complexes. A 13C NMR Study
The Determination of the Three Dimensional Structure of Human Epidermal Growth Factor from 1H-NMR Data
Conformational Comparison of Four Constrained Stereoisomeric Cyclic Enkephalin Analogs by 1H NMR and Computer Simulations
Opioid Peptides in Micellar Systems: Conformational Analysis by 1D and 2D 1H-NMR and Circular Dichroism
Long, Chiral Polypeptide 310-Helices
C.3. X-Ray Studies
Uses of Synchrotron X-Radiation in Biological Crystallography
X-Ray Crystallography of Linear Peptides Through the Renin-Angiotensin System
C.4. Conformation in Solution
Identification of Folded Structures in Immunogenic Peptides by 2D NMR Spectroscopy
Conformational Properties of Calcitonin and their Relationship to Biological Activity
On the Difference Between Molecular Conformation and Hydrogen Bonding in Solution and in Crystalline State
Antiprotease Engineering: New Protease Inhibitors for Therapeutic Use
Enkephalinase, A Metalloendopeptidase Involved in the Inactivation of Biologically Active Peptides
Neutron Scattering Analysis of Angiotensin-Converting Enzyme (ACE)
C.5. Antigen-Antibody Binding
Immunochemical Study of Cyclosporine Conformation in Aqueous Medium
Localization of Two Epitopes with Monoclonal Antibodies in the Cell Attachment Domain of Fibronectin by Synthetic Peptides
Immunoreactivity and Biological Activity of Thymulin Analogs Studied by EIA and Rosette Assay
Affinity Constant and "In Vitro" Biological Activity of Human Monoclonal Antibodies Against Rh (D) Antigen
Contiguous and Discontiguous Antigenic Determinants on Proteins
Author Index
Subject Index
Product details
- No. of pages: 556
- Language: English
- Copyright: © Pergamon 1987
- Published: January 1, 1987
- Imprint: Pergamon
- eBook ISBN: 9781483148380
About the Editor
H. Peeters
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