Protides of the Biological Fluids

Protides of the Biological Fluids

Proceedings of the Twentieth Colloquium, Brugge, 1972

1st Edition - January 1, 1973

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  • Editor: H. Peeters
  • eBook ISBN: 9781483158334

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Protides of the Biological Fluids: Twentieth Volume is a collection of studies about three selected topics from the general field of protein chemistry. The book is divided into four sections. Section A covers monoclonal immunoglobulins and its properties and structure; the amyloid substance; and antibody function. Section B covers active polypeptides derived from plasma proteins; the kinin system; the angiotensin and renin system; anaphylatoxins; and protease inhibitors. Section C covers microcalorimetry in biological systems; biological system and its relation with thermodynamics; and the application of microcalorimetry to biological systems. The book also includes a Section D, which does not consider any of the selected topics, but instead focuses on other techniques such as the double line method; radioimmunoassay of alpha-fetoprotein; and the IgM latex test. The text is recommended for students and reseearchers in the fields of biology, biochemistry, and other related fields, especially those who wish to learn more about monoclonal immunoglobulins, fibrinopeptides, and the effect of microcalorimetry in biological systems.

Table of Contents

  • Preface


    Academic Lecture

    Science and Society

    The First Arne Tiselius Memorial Lecture

    Separation Methods: Tools of Progress in Proteins

    Section A: Monoclonal Immunoglobulins (MIg)

    A1. Properties and Structure of MIg

    Principles of Immunoglobulin Structure in Relation to Aberrations in Protein Metabolism

    Monoclonal IgM-Globulin with Anti-IgG Activity: An Immunofluorescent and Electron Microscopic Study

    Structural Studies of Human IgG Monoclonal Proteins Using Sodium Dodecyl Sulphate-Polyacrylamide Gel Electrophoresis

    Insolubilization of a Fraction of Human IgG in a Salted Phenol Solution

    A2. The Amyloid Substance (AS)

    A2.1 Chemical, Immunochemical and Ultrastructural Studies of the AS

    The Immunoglobulin Origin of Amyloid Fibril Proteins

    The Subunit Structure and Immunologic Properties of Amyloid Fibrils

    Ultrastructure and Composition of Amyloid — Variable or Constant

    The Chemical Classes of Amyloid Substance in Men, Monkeys and Ducks

    Isolation and Characterization of a Low Molecular Weight Peptide from Human Amyloid

    A Non-immunoglobulin Protein — The Major Component of Some Human Amyloids

    Studies on the Antigenic and Immunochemical Properties of Amyloid Fibrils

    Studies with Conformational Antisera to Amyloid

    The Acid-soluble Fraction of Amyloid — The Protein Subunit of the Amyloid Fibril

    Similarity in Amino Acid Composition between Human Light Chain and Some Amyloid Proteins

    A2.2 Production and Deposition of the AS in Cells and Tissues

    Vital Dyeing Processes and Exchange Phenomena at the Amyloid Deposits

    Interactions of Congo Red and Toluidine Blue with Amyloid

    Cellular Immunity and Amyloidosis

    A2.3 Clinical and Experimental Aspects of Amyloidosis

    Experimental Amyloidosis and High Dosage Tolerance to Casein

    F1, Rauscher and Moloney Leukemia Viruses Inhibiting and Enhancing Amyloid Development in Casein-treated C3H Mice

    Amyloidosis, Multiple Myeloma and Aging

    Coincidence of Amyloidosis and Monoclonal Gammopathies — A Study of 82 Cases

    Senile Amyloidosis of Arterial Elastica Interna

    Pathogenic Mechanisms in Experimental Murine Amyloidosis

    Amyloidosis and Immunology. Amyloid Degeneration and Lingering Tuberculosis in the Aged

    A3. The Antibody Function of MIg

    A3.1 Restricted Antibodies

    Monoclonal Antibodies to Streptococcal Polysaccharides in Rabbit and Mouse

    Limited Heterogeneity of Antibodies in Individual Animals

    Partial Amino Acid Sequence of Rabbit Antibody Heavy Chain Variable Regions

    Deviations in the Balance of Intracellular Heavy- and Light-Chain Determinants in Human Plasma Cells

    Genetic Determination of Idiotypes in Antibodies to the Group-specific Polysaccharides of Streptococci

    The Number of Unique Monoclonal Antibodies Against a Simple Hapten in CBA Mice

    Mouse Antibodies with Electrophoretic Restriction

    Kappa-type Immunoglobulin Light Chains of Rat Strain LOU/Wsl

    A3.2 Pathological MIg

    An IgM Waldenstrom Protein with Anti-phosphorylcholine Specificity

    Extreme ASO Activity in an IgG Kappa Myeloma Protein

    Monoclonal Immunoglobulins at the Lymphocyte Surface in Immunoproliferative Disorders

    Immunoglobulin Analysis in Families of Myeloma Patients

    Lymphocytotoxic Activities of Sera from Myeloma and Other Paraproteinemic Patients

    Paraprotein Production and Induction of Glomerulonephritis by Mouse Plasmacytoma Cells Transferred to Hamsters

    Complement Levels in Patients with IgG Monoclonal Gammopathies

    Correlations Between the Serum Concentrations of IgG Myeloma Proteins and Background IgG

    Clinical Significance of Bence-Jones Proteinuria

    Immunoglobulin Restricted Heterogeneity in Subacute Sclerosing Panencephalitis

    Paraproteinaemia in Blood Donors and the Aged: Benign and Malignant

    Transitory Appearance of Homogeneous Immunoglobulins — "Paraproteins" — in Children with Severe Combined Immunodeficiency Before and After Transplantation Treatment

    The Stability of Serum Immunoglobulin Levels in Health and Rheumatoid Arthritis

    The IgG Subclass Distribution in Double M-component Sera

    J-chain of Polymeric IgA Myeloma Proteins

    Section B: Active Polypeptides derived from Plasma Proteins

    B1. Fibrinopeptides

    Solid Phase Synthesis of Human Fibrinopeptides A and B

    A Quantitative Study of Physiologic Effects of Peptides Derived from Human Fibrinogen by Plasmin Digestion

    The Effect of Fibrinogenolytic Products on Plasma Fibrinogen Concentration

    Preparation and Clinical Use of Antibody Specific to Fibrinopeptide A

    Prevention of Fibrinogen Coagulation by Specific Antifibrinogen Antibodies

    B2. Kinin System

    The Interrelationship Between the Clotting, Fibrinolytic and Kinin Systems of Human Plasma

    Application of an Insoluble Hageman Factor Complex to Kinin Research

    Inhibitors of the Pulmonary Destruction of Bradykinin in the Rat

    On the Inhibitory Capacity of Human Plasma Protein Fractions Against Plasminogen Activation

    Some Physico-chemical Parameters of the Perivascular Plasminogen Activator Angiokinase

    Kallikreinogen and Kallikrein Inhibitor in Cerebral Stroke

    The Role of Bradykinin in the Inflammation of Skin

    Kininase Activity of the Blood in Various Haematological States

    The Effect of Urea on the Release from Proteinic Macromolecules of Some Factors with Kininic and Stimulator Activity of Phagocytosis

    Evidence for Kinins, Histamine and Complement as Mediators of the Inflammatory Response

    B3. Angiotensin and Renin System

    The Metabolism of Angiotensin I by Endothelial Cells

    Angiotensin Receptors in Smooth Muscle Cell Membranes

    Renin in the Spontaneously Hypertensive Rat

    B4. Anaphylatoxins

    Anaphylatoxin and Other Biologically Active Products of Complement

    Enzymatic Formation of Active Polypeptides in the Human Skin

    Generation of Anaphylatoxin Activity Through Bypass Activation of the Complement System

    Regulation of Chemotaxis of Leucocytes by the Anaphylatoxin-related Peptide System

    B5. Protease Inhibitors

    New Proteinase Inhibitors in the Secretion of Some Mucous Membranes of the Human Body

    Protein Proteinase Inhibitors in Male Sex Glands and their Secretions

    Fibrin-agar-electrophoretic Study of Polyvalent Proteinase Inhibitors from Snails

    Low-molecular-weight Proteinase Isoinhibitors of Broad Specificity from the Skin of Snails

    Preparation of Human C1 Esterase Inhibitor Concentrate and its Possible Clinical Use

    Section C: Microcalorimetry in Biological Systems

    C1. Thermodynamics: Structure and Interaction Studies

    Calorimetric Studies of Hapten-Antibody Interaction

    Calorimetric Studies of Binding of Substrates and Inhibitors to Triosephosphate Isomerase

    Thermodynamics of Interaction of Pyridoxal Phosphate with Transaminase and Model Systems

    Analytical and Microcalorimetric Investigation of the Adsorption of Human Serum Albumin on Well-defined Polystyrene Latices

    Study of Competition Binding on BSA by Microcalorimetry

    Calorimetric Study of Bound Water in Protein Solutions and in Human Red Blood Cells

    Microcalorimetric Investigations of Biopolymer Aqueous Solutions

    Thermodynamic Studies on Iron (III) Exchange Between Chelates and Human Transferrin

    Conformational Study of Lysozyme in the Crystal and in Solution, Using Microcalorimetry

    A Microcalorimetric Study of Haptoglobin — Hemoglobin Interaction

    Investigation of Carrier Antibiotics by Computerized Microcalorimetry

    Thermodynamics of Protein Interactions

    A Calorimetric Study of the Intluence of Ionic Strength on the Binding of Inhibitors to Ribonuclease A

    Calorimetric Investigations of the Interaction of Inhibitors and Substrates with Ribonuclease A and Ribonuclease T1

    C2. Applications to Biological Systems

    Use of Flow Microcalorimetry for Activity Determination of Proteolytic Enzymes

    Investigation of Time-dependent Processes by Heat Flow Calorimetry

    Microcalorimetric Experiments on a Cell-free Protein Synthesizing System of Saccharomyces

    The Action of Thrombin on Platelets: A Microcalorimetric Study

    Metabolic Activity of Erythrocytes as Determined by Microcalorimetry

    The Measurement of Kinetic and Thermodynamic Parameters for Reacting Systems by Flow Microcalorimetry and Application of the Method to the Urea—Urease System in a Sodium Phosphate Buffer

    Matrix-bound Enzymes Studied by Flow Microcalorimetry

    Section D: Other Techniques

    The Double-line Method; Simultaneous Determination of Both Light-chain Types in Monoclonal and Polyclonal IgG

    Radioimmunoassay of α-Fetoprotein

    Quantitative Study of Tests Using Latex Particles Coated with Proteins or Peptides

    Detection of Albumin- IgG Complexes in γ-globulin Preparations

    The IgM Latex Test, a Simple Method for Rapid Detection of Infections in the Neonatal Period

    Author Index

    Subject Index

Product details

  • No. of pages: 628
  • Language: English
  • Copyright: © Pergamon 1973
  • Published: January 1, 1973
  • Imprint: Pergamon
  • eBook ISBN: 9781483158334

About the Editor

H. Peeters

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