Proteomics and Systems Biology

Proteomics and Systems Biology

1st Edition - July 23, 2021

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  • Editors: Rossen Donev, Tatyana Karabencheva-Christova
  • eBook ISBN: 9780323853200
  • Hardcover ISBN: 9780323853194

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Proteomics and Systems Biology, Volume 127 in the Advances in Protein Chemistry and Structural Biology series, outlines current proteomic methodologies and discuss the challenges in future applications of systems biology in a number of biomedical/bioscience subjects. In last few decades, advances in genomics, proteomics, metabolomics, glycomics, venomics, etc., have produced vast large-scale datasets that need to be analyzed with a single main objective of understanding biological systems as a whole. Such understanding will allow us to predict and characterize the dynamic properties of biological systems.

Key Features

  • Integrates experimental and computational methods for understanding biological systems as a whole
  • Contains timely chapters written by well-renowned authorities in their field
  • Includes well supported content that is accompanied by a number of high-quality illustrations, figures and tables, hence it targets a wide audience of specialists, researchers and students


Specialists in proteomics, computational modelling and experimental biologists working on prediction and characterisation of the dynamic properties of biological systems. Published herein articles would be of scholarly interest also to students in the abovementioned fields

Table of Contents

  • 1. Using proteomic and transcriptomic data to assess activation of intracellular molecular pathways
    Anton Buzdin, Victor Tkachev, Marianna Zolotovskaia, Andrew Garazha, Sergey Moshkovskii, Nicolas Borisov, Nurshat Gaifullin, Maksim Sorokin, and Maria Suntsova
    2. Proteomics in systems toxicology
    Carolina Madeira and Pedro M. Costa
    3. Posttranslational modifications in systems biology
    Suruchi Aggarwal, Priya Tolani, Srishti Gupta, and Amit Kumar Yadav
    4. Big data, integrative omics and network biology
    Priya Tolani, Srishti Gupta, Kirti Yadav, Suruchi Aggarwal, and Amit Kumar Yadav
    5. Proteome analysis using machine learning approaches and its applications to diseases
    Abhishek Sengupta, G. Naresh, Astha Mishra, Diksha Parashar, and Priyanka Narad
    6. Network-based strategies for protein characterization
    Alessandra Merlotti, Giulia Menichetti, Piero Fariselli, Emidio Capriotti, and Daniel Remondini
    7. Proteomics and systems biology in optic nerve regeneration
    Sean D. Meehan, Leila Abdelrahman, Jennifer Arcuri, Kevin K. Park, Mohammad Samarah, and Sanjoy K. Bhattacharya
    8. Proteomics of pseudoexfoliation materials in the anterior eye segment
    Jada Morris, Ciara Myer, Tara Cornet, Anna K. Junk, Richard K. Lee, and Sanjoy K. Bhattacharya
    9. A systems biology approach to COVID-19 progression in population
    Magdalena Djordjevic, Andjela Rodic, Igor Salom, Dusan Zigic, Ognjen Milicevic, Bojana Ilic, and Marko Djordjevic
    10. An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)—A systems biology approach 315
    S. Udhaya Kumar, N. Madhana Priya, D. Thirumal Kumar, V. Anu Preethi, Vibhaa Kumar, Dhanushya Nagarajan, R. Magesh, Salma Younes, Hatem Zayed, and C. George Priya Doss
    11. A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis
    S. Udhaya Kumar, Aisha Saleem, D. Thirumal Kumar, V. Anu Preethi, Salma Younes, Hatem Zayed, Iftikhar Aslam Tayubi, and C. George Priya Doss

Product details

  • No. of pages: 380
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: July 23, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780323853200
  • Hardcover ISBN: 9780323853194

About the Serial Volume Editors

Rossen Donev

Rossen Donev
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on development of immunotherapeutics for non-systemic applications.

Affiliations and Expertise

Head of Research, MicroPharm Limited, UK

Tatyana Karabencheva-Christova

Dr. Tatyana Karabencheva-Christova works at the Department of Applied Sciences, University of Northumbria, UK.

Affiliations and Expertise

Department of Chemistry, Michigan Technological University, Houghton, MI, USA

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