Proteolytic Signaling in Health and Disease

Proteolytic Signaling in Health and Disease

1st Edition - October 13, 2021

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  • Editor: Andre Zelanis
  • Paperback ISBN: 9780323856966
  • eBook ISBN: 9780323856973

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In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events.

Key Features

  • Examines biological events triggered by proteolytic enzyme activity across human development and pathologies
  • Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types
  • Features methods and protocols supporting further study of proteolytic signaling events
  • Includes chapter contributions from international leaders in the field


Life science researchers in biochemistry, molecular biology, and cell biology; clinical chemists and pharmaceutical scientists; and medical and analytical chemists. Clinicians and students

Table of Contents

  • 1. Proteolytic signalling: an introduction

    André Zelanis, Uilla Barcick and Maurício F. Camacho

    2. Ubiquitin-ligases: proteolytic signaling, protein turnover, and disease

    Felipe Roberti Teixeira, Patricia Passos, Camila Correia, Caio Almeida, Valentine Spagnol and Isabela Fernanda Morales Martins

    3. Lysosomal proteases and their role in signaling pathways

    Rebecca A.B. Burton, Samuel Bose and Thamali Ayagama

    4. Antigen processing and presentation through MHC molecules

    Niels Olsen Saraiva Câmara, Tamisa Honda and Barbara Padovani

    5. Proteolytic processing in autophagy

    João Agostinho Machado-Neto and Andrei Leitão

    6. Proteolysis in inflammatory diseases

    Antoine Dufour and Luiz de Almeida

    7. Proteolytic processing of laminin and the role of cryptides in tumoral biology

    Vanessa Morais Freitas, Ruy Gastaldoni Jaeger and Adriane Sousa de Siqueira

    8. Proteolytic signaling in wound healing

    Ulrich auf dem Keller, Konstantinos Kalogeropoulos and Louise Bundgaard

    9. Proteinases disbalance in oral cancer and other diseases

    Adriana Franco Paes Leme

    10. ‘Omics’ approaches for investigating protease degradomes in complex biological matrices

    Pitter F. Huesgen and Maithreyan Kuppusamy

    11. Protease web

    Nikolaus Fortelny and Wolfgang Esser-Skala

    12. The puzzle of proteolytic effects in hemorrhage induced by Viperidae snake venom metalloproteinases

    Milene Menezes, Dilza Trevisan-Silva, Daniela Cajado De Oliveira Souza Carvalho and Jessica de Alcantara Ferreira

Product details

  • No. of pages: 308
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: October 13, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780323856966
  • eBook ISBN: 9780323856973

About the Editor

Andre Zelanis

Dr. André Zelanis is Assistant professor of Proteomics and Systems Biology, and Head of the Functional Proteomics Laboratory at the Department of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil. His research focuses in proteomics and mass spectrometry-based approaches to uncover protease function in biological signaling pathways. Currently his lab is using proteomics to explore the repertoire of substrates (degradome) of proteases secreted by melanoma cells in culture and evaluating proteolytic processing events in the plasma of patients with metastatic melanoma. He has published widely in such peer reviewed journals as the Journal of Proteome Research and Comparative Biochemistry and Physiology.

Affiliations and Expertise

Assistant professor of Proteomics and Systems Biology, and Head, Functional Proteomics Laboratory, Department of Science and Technology, Federal University of Sao Paulo, Sao Jose dos Campos, Brazil

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