Proteolytic Enzymes: Aspartic and Metallo Peptidases, Volume 248

1st Edition

Serial Volume Editors: Alan Barrett
Hardcover ISBN: 9780121821494
eBook ISBN: 9780080883618
Imprint: Academic Press
Published Date: 22nd June 1995
Page Count: 873

Unavailable

This product is currently not available for sale.

Table of Contents

Methods: J.C. Powers and C.-M. Kam, Peptide Thioester Substrates for Serine Peptidases and Metalloendopeptidases. C.G. Knight, Fluorimetric Assays of Proteolytic Enzymes. G.M. McGeehan, D.M. Bickett, J.S. Wiseman, M. Green, and J. Berman, Defined Substrate Mixtures for Mapping of Proteinase Specificities. C.J. Handley and D.J. Buttle, Assay of Proteoglycan Degradation. J.G. Bieth, Theoretical and Practical Aspects of Proteinase Inhibition Kinetics. C.G. Knight, Active-Site Titration of Peptidases. Aspartic Peptidases: N.D. Rawlings and A.J. Barrett, Families of Aspartic Peptidases, and Those of Unknown Catalytic Mechanism. T. Kageyama, Procathepsin E and Cathepsin E. Y.P. Loh and N.X. Cawley, Processing Enzymes of Pepsin Family: Yeast Aspartic Protease 3 and Pro-opiomelanocortin Converting Enzyme. K. Takahashi, Proteinase A from Aspergillus niger. X. Lin and J. Tang, Thermopsin. K. Sankaran and H.C. Wu, Bacterial Prolipoprotein Signal Peptidase. Metallopeptidases: N.D. Rawlings and A.J. Barrett, Evolutionary Families of Metallopeptidases. D.S. Auld, Removal and Replacement of Metal Ions in Metallopeptidases. K. Morihara, Pseudolysin and Other Pathogen Endopeptidases of Thermolysin Family. C. Li and L.B. Hersh, Neprilysin: Assay Methods, Purification, and Characterization. B.P. Roques, F. Noble, P. Crine, and M.-C. Fournie-Zaluski, Inhibitors of Neprilysin: Design, Pharmacological and Clinical Applications. P. Corvol, T.A. Williams, and F. Soubrier, Peptidyl Dipeptidase A: Angiotensin I-Convert

Description

In this volume of Methods in Enzymology and its companion Volume 244, the chapters on specific methods, enzymes, and inhibitors are organized within the rational framework of the new systems for classificationand nomenclature. A wide variety of specificities of peptide bond hydrolysis are represented in each set of peptidases, together with an equally wide range of biological functions.

Key Features

@introbul:Key Features @bul:* Aspartic peptidases

  • Metallopeptidases
  • New information on classification of proteolytic enzymes
  • Medical implications of research in this area
  • Biotechnological uses of these enzymes

Readership

Biochemists, molecular biologists, cell biologists, microbiologists, physiologists, neuroscientists, and immunologists.


Details

No. of pages:
873
Language:
English
Copyright:
© Academic Press 1995
Published:
Imprint:
Academic Press
eBook ISBN:
9780080883618
Hardcover ISBN:
9780121821494

Reviews

@from:Praise for the Volume @qu:"Because this is a very significant and timely review, this book is a worthy contribution to any chemical, biological, or medical library for those interested not only in proteases but also their physiologic roles in matrix degradation and post-translational processing." @source:--DOODY'S JOURNAL @from:Praise for the Series @qu:"The Methods in Enzymology series represents the gold-standard." @source:--NEUROSCIENCE @qu:"Incomparably useful." @source:--ANALYTICAL BIOCHEMISTRY @qu:"It is a true 'methods' series, including almost every detail from basic theory to sources of equipment and reagents, with timely documentation provided on each page." @source:--BIO/TECHNOLOGY @qu:"The series has been following the growing, changing and creation of new areas of science. It should be on the shelves of all libraries in the world as a whole collection." @source:--CHEMISTRY IN INDUSTRY @qu:"The appearance of another volume in that excellent series, Methods in Enzymology, is always a cause for appreciation for those who wish to successfully carry out a particular technique or prepare an enzyme or metabolic intermediate without the tiresome prospect of searching through unfamiliar literature and perhaps selecting an unproven method which is not easily reproduced." @source:--AMERICAN SOCIETY OF MICROBIOLOGY NEWS @qu:"If we had some way to find the work most often consulted in the laboratory, it could well be the multi-volume series Methods in Enzymology...a great work." @source:--ENZYMOLOGIA @qu:"A series that has established itself as a definitive reference for biochemists." @source:--JOURNAL OF CHROMATOGRAPHY


About the Serial Volume Editors

Alan Barrett Serial Volume Editor

Affiliations and Expertise

Wellcome Trust Sanger Institute, Cambridge, U.K.