Proteolysis and Physiological Regulation

Proteolysis and Physiological Regulation

1st Edition - January 1, 1976

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  • Editor: D Ribbons
  • eBook ISBN: 9780323150798

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Miami Winter Symposia, Volume 11: Proteolysis and Physiological Regulation contains the proceedings of the University of Miami's Biochemistry Department Symposium on "Proteolysis and Physiological Regulation", which is published simultaneously with the proceedings of the Papanicolaou Cancer Research Institute's Symposium on "Cancer Enzymology" (Volume 12). This volume is composed of 35 chapters and begins with surveys of the structural properties and role of various enzymes in biological regulation. The subsequent chapters describe the structure-activity relationship, cellular production, selectivity, mechanisms, and substrate specificity of the enzymes. Other chapters explore the activation, regulation, biosynthesis, and other biological activities of other enzymes. The remaining chapters discuss property modification, metabolism, binding, and other biological aspects of enzymes. This book will prove useful to enzyme scientists, cell biologists, biochemists, and researchers.

Table of Contents

  • Speakers, Chairmen, and Discussants


    The Seventh Feodor Lynen Lecture My Life with Proteins and Their Prosthetic Groups

    The Role of Proteases in Biological Regulation

    Structural Studies on the Pancreatic Trypsin Inhibitor-Trypsin Complex and Its Free Components: Structure and Function Relationship in Serine Protease Inhibition and Catalysis

    The Proteolytic Enzymes of the K-1 Strain of Streptomyces Griseus Obtained from a Commercial Preparation (Pronase). XI. Evolutionary Implications

    Relationships Between the Structures and Activities of Some Microbial Serine Proteases. I. Purification, Enzymic Properties, and Primary Structures of Streptomyces Griseus Proteases A, B, and Trypsin

    Relationship Between the Structures and Activities of Some Microbial Serine Proteases. II. Comparison of the Tertiary Structures of Microbial and Pancreatic Serine Proteases

    Biological Functions of Activated Complement Proteins in Normal and Disease States

    The Nature and Reactions of Complement Enzymes

    Serine Proteases of Coagulation and Their Inhibitors

    Homologous "Kringle" Structures Common to Plasminogen and Prothrombin. Substrate Specificity of Enzymes Activating Pro-Thrombin and Plasminogen

    Fibrin Formation and Dissolution

    Proteases Produced by Normal and Malignant Cells in Culture

    The Role of Lysosomes in Protein Turnover

    Studies of the Selectivity and Mechanisms of Intracellular Protein Degradation

    The Role of Neutral and Acid Proteinases in Connective Tissue Turnover

    Proteolytic Control of Collagen Breakdown

    Substrate Specificity in Pinocytosis and Intralysosomal Protein Digestion

    Poster Session: Communications

    Activation of Cuticle Chitinase: A Probable New Instance of Activation by Partial Proteolysis

    Effects of Added Nucleophiles on the Cathepsin B1 Catalyzed Hydrolysis of CBZ-L-Lysine p-Nitrophenyl Ester. Evidence for an Acyl Enzyme Intermediate and Leaving Group Specificity

    Regulation of the Leukocyte Proteinases by the Human Plasma Proteinase Inhibitors

    An Estimation of the Distance from the Active Site to the Calcium Binding Site in Trypsin

    Natural and Synthetic Peptide Inhibitors of Pepsin

    Further Evidence for a Proton Pump in Phagolysosomes and the Involvement of Lysosomes in Protein Turnover

    Intracellular Cysteine Proteases from Bovine Liver

    Charge Relay of Serine Proteinases: NMR Studies of Free and Inhibited Forms of Trypsin and Chymotrypsin

    Modification of the Properties of Trypsin by Covalent Attachment of Polysaccharide

    Autocatalytic Activation of Cls

    Vitamin Κ - Dependent Synthesis and Modification of Precursor Prothrombin in Cultured Liver Cells

    On the Specificities of Proteases in the Healing Human Burn Wound

    Protein Metabolism in Fetal Rat Liver from Chronic Alcoholic Mothers

    Neutral and Acid Metalloproteinases in Human Articular Cartilage Which Degrade Proteoglycan

    Proteinases and Proteinase Inhibitors in Fertilization

    Characterisation of Elastase and Chymotrypsin from Human Granulocyte Lysosomes

    Thermodynamics of Substrate Analog Binding to Native and Modified Forms of α-Chymotrypsin; A Study in "Productive" and Non-Productive Binding

    Inhibition of Lethality in Endotoxin Challenged Mice Treated with Zinc Chloride

    Relationship Between Zinc Content and Trypsin Binding Activity of Alpha2 -Macroglobulin

    Measurement of Rat Protein Metabolism In Vivo

Product details

  • No. of pages: 428
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 1, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9780323150798

About the Editor

D Ribbons

Affiliations and Expertise

Department of Biochemistry, University of Miami School of Medicine, and Howard Hughes Medical Institute, Miami, Florida, U.S.A.

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