Proteolysis and Physiological Regulation - 1st Edition - ISBN: 9780125882507, 9780323150798

Proteolysis and Physiological Regulation

1st Edition

Editors: D.W. Ribbons
eBook ISBN: 9780323150798
Imprint: Academic Press
Published Date: 1st January 1976
Page Count: 428
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Miami Winter Symposia, Volume 11: Proteolysis and Physiological Regulation contains the proceedings of the University of Miami's Biochemistry Department Symposium on "Proteolysis and Physiological Regulation", which is published simultaneously with the proceedings of the Papanicolaou Cancer Research Institute's Symposium on "Cancer Enzymology" (Volume 12).

This volume is composed of 35 chapters and begins with surveys of the structural properties and role of various enzymes in biological regulation. The subsequent chapters describe the structure-activity relationship, cellular production, selectivity, mechanisms, and substrate specificity of the enzymes. Other chapters explore the activation, regulation, biosynthesis, and other biological activities of other enzymes. The remaining chapters discuss property modification, metabolism, binding, and other biological aspects of enzymes.

This book will prove useful to enzyme scientists, cell biologists, biochemists, and researchers.

Table of Contents

Speakers, Chairmen, and Discussants


The Seventh Feodor Lynen Lecture My Life with Proteins and Their Prosthetic Groups

The Role of Proteases in Biological Regulation

Structural Studies on the Pancreatic Trypsin Inhibitor-Trypsin Complex and Its Free Components: Structure and Function Relationship in Serine Protease Inhibition and Catalysis

The Proteolytic Enzymes of the K-1 Strain of Streptomyces Griseus Obtained from a Commercial Preparation (Pronase). XI. Evolutionary Implications

Relationships Between the Structures and Activities of Some Microbial Serine Proteases. I. Purification, Enzymic Properties, and Primary Structures of Streptomyces Griseus Proteases A, B, and Trypsin

Relationship Between the Structures and Activities of Some Microbial Serine Proteases. II. Comparison of the Tertiary Structures of Microbial and Pancreatic Serine Proteases

Biological Functions of Activated Complement Proteins in Normal and Disease States

The Nature and Reactions of Complement Enzymes

Serine Proteases of Coagulation and Their Inhibitors

Homologous "Kringle" Structures Common to Plasminogen and Prothrombin. Substrate Specificity of Enzymes Activating Pro-Thrombin and Plasminogen

Fibrin Formation and Dissolution

Proteases Produced by Normal and Malignant Cells in Culture

The Role of Lysosomes in Protein Turnover

Studies of the Selectivity and Mechanisms of Intracellular Protein Degradation

The Role of Neutral and Acid Proteinases in Connective Tissue Turnover

Proteolytic Control of Collagen Breakdown

Substrate Specificity in Pinocytosis and Intralysosomal Protein Digestion

Poster Session: Communications

Activation of Cuticle Chitinase: A Probable New Instance of Activation by Partial Proteolysis

Effects of Added Nucleophiles on the Cathepsin B1 Catalyzed Hydrolysis of CBZ-L-Lysine p-Nitrophenyl Ester. Evidence for an Acyl Enzyme Intermediate and Leaving Group Specificity

Regulation of the Leukocyte Proteinases by the Human Plasma Proteinase Inhibitors

An Estimation of the Distance from the Active Site to the Calcium Binding Site in Trypsin

Natural and Synthetic Peptide Inhibitors of Pepsin

Further Evidence for a Proton Pump in Phagolysosomes and the Involvement of Lysosomes in Protein Turnover

Intracellular Cysteine Proteases from Bovine Liver

Charge Relay of Serine Proteinases: NMR Studies of Free and Inhibited Forms of Trypsin and Chymotrypsin

Modification of the Properties of Trypsin by Covalent Attachment of Polysaccharide

Autocatalytic Activation of Cls

Vitamin Κ - Dependent Synthesis and Modification of Precursor Prothrombin in Cultured Liver Cells

On the Specificities of Proteases in the Healing Human Burn Wound

Protein Metabolism in Fetal Rat Liver from Chronic Alcoholic Mothers

Neutral and Acid Metalloproteinases in Human Articular Cartilage Which Degrade Proteoglycan

Proteinases and Proteinase Inhibitors in Fertilization

Characterisation of Elastase and Chymotrypsin from Human Granulocyte Lysosomes

Thermodynamics of Substrate Analog Binding to Native and Modified Forms of α-Chymotrypsin; A Study in "Productive" and Non-Productive Binding

Inhibition of Lethality in Endotoxin Challenged Mice Treated with Zinc Chloride

Relationship Between Zinc Content and Trypsin Binding Activity of Alpha2 -Macroglobulin

Measurement of Rat Protein Metabolism In Vivo


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© Academic Press 1976
Academic Press
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About the Editor

D.W. Ribbons

Affiliations and Expertise

Department of Biochemistry, University of Miami School of Medicine, and Howard Hughes Medical Institute, Miami, Florida, U.S.A.

Ratings and Reviews