Protein Turnover and Lysosome Function - 1st Edition - ISBN: 9780126361506, 9781483220192

Protein Turnover and Lysosome Function

1st Edition

Editors: Harold L. Segal Darrell J. Doyle
eBook ISBN: 9781483220192
Imprint: Academic Press
Published Date: 1st January 1978
Page Count: 810
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Description

Protein Turnover and Lysosome Function comprises the proceedings of a symposium under the same title held at the State University of New York at Buffalo on August 21-26, 1977. The book discusses mechanisms of protein turnover, as well as the identification and characterization of intracellular proteases. The text also describes the internalization of macromolecules into the intracellular digestive system; the types of specificity entailed; and the fate of the membrane material involved in the vacuolization process. Biochemists, pathologists, cell biologists, molecular biologists, and physiologists will find the book invaluable.

Table of Contents


List of Contributors

Preface

Introduction

Mechanisms and Regulation of Protein Turnover

Factors Involved in the Regulation of Protein Turnover

Lysosomal Mechanisms of Protein Degradation

Some Aspects of the Intracellular Breakdown of Exogenous and Endogenous Proteins

Evidence for a Proton Pump in Rat Liver Lysosomes

Lysosomal Processing of Intracellular Protein in Rat Liver and Its General Regulation by Amino Acids and Insulin

In Vivo Determination of Rates of Protein Degradation in Livers of Meal-Fed Rats: Implications of Amino Acid Compartmentation

The General Characteristics of Intracellular Protein Degradation in Diabetes and Starvation

The Significance of Protein Degradation in the Regulation of Liver Growth

Turnover of the Major Proteins of Rat Erythrocytes

Mode of Degradation of Abnormal Globin Chains in Rabbit Reticulocytes

Selective Degradation of Abnormal Proteins in Animal and Bacterial Cells

Mechanisms in Intracellular Turnover of Stable and Labile Enzymes

Studies on Protein Degradation in Isolated Hepatocytes and Kupffer Cells

The Chemistry and Turnover of Lysosomal Enzymes

Genetics of Lysosomal Functions

Measurement of Protein, Synthesis and Turnover in Animal Cells with Tritiated Water

Turnover of Soluble Protein in Growing Cultures of Escherichia coli

Lysosomal and Nonlysosomal Proteases

Lysosomal Proteinases and Their Specificity

Control of Proteolysis in Yeast

Collagenolytic Activity of Lung BANA Hydrolase and Cathepsin B1

Modification of Fructose 1,6-Bisphosphatase by Lysosomal Proteinases

Bovine Spleen Cathepsins D and S: Purification, Characterization, and Structural Studies

Characterization of Two Unique Protease Inhibitors and a Calcium-Activated Protease from Bovine Cardiac Muscle

Protein Catabolism in Rat Liver Cells

Uptake of Proteins into the Lysosomal System

Lysosomal Digestion of Endoctosed Proteins: Opportunities and Problems for the Cell

Uptake and Degradation of Proteins in Isolated Rat Liver Cells

Protein Turnover in Isolated Rat Hepatocytes

Receptor-Mediated Uptake of Macromolecules and Their Delivery to Lysosomes in Human Fibroblasts

Specific Recognition and Uptake of Lysosomal Enzymes and Modified Glycoproteins by Rat Tissues

Phosphohexose on Lysosomal Enzymes is the Common Recognition Marker for Pinocytosis Receptor on Fibroblasts

A Role for Lysosomes in Corpus Luteum Function

The Use of Lipid Vesticles for Introducing Macromolecules into Cells

The Inhibitory Effect of 2-Deoxy-D-glucose on Fc and C3b Receptor-Mediated Phagocytosis in Phagocytic Cells

Protein Turnover in Muscle and Heart

A Ca2+-Activated Muscle Protease in Myofibrillar Protein Turnover

Cathepsins B and D: Proteolytic Activity and Ultrastructural Localization in Skeletal Muscle

Inhibition of Muscle Degeneration Using Protease Inhibitors

Partial Characterization of a Protease from Cardiac Myofibrils of Dystrophic Hamsters

Factors Affecting Protein Breakdown in Skeletal Muscle

Changes in the Turnover Rates of Myosin Heavy Chain and Actin in Cultured Chick Embryo Heart Cells

Studies on the Regulation of Protein Concentrations in Red and White Skeletal Muscles

Turnover of Membrane Proteins

Turnover and Biogenesis of the Plasma Membrane Proteins of Hepatoma Tissue Culture Cells

A Shuttle between Cell Surface and Lysosomes during Endocytosis

Turnover of Plasma Membrane Precursor Pools in Virus-Infected and Uninfected HeLa Cells

Regulation of Insulin and Growth Hormone Receptors in Vitro and in Vivo

Turnover of Proteins and Glycoproteins of Plasma Membranes in Liver, Regenerating Liver, and Morris Hepatomas


Details

No. of pages:
810
Language:
English
Copyright:
© Academic Press 1978
Published:
Imprint:
Academic Press
eBook ISBN:
9781483220192

About the Editor

Harold L. Segal

Darrell J. Doyle