Protein Turnover and Lysosome Function

Protein Turnover and Lysosome Function

1st Edition - January 1, 1978

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  • Editors: Harold L. Segal, Darrell J. Doyle
  • eBook ISBN: 9781483220192

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Protein Turnover and Lysosome Function comprises the proceedings of a symposium under the same title held at the State University of New York at Buffalo on August 21-26, 1977. The book discusses mechanisms of protein turnover, as well as the identification and characterization of intracellular proteases. The text also describes the internalization of macromolecules into the intracellular digestive system; the types of specificity entailed; and the fate of the membrane material involved in the vacuolization process. Biochemists, pathologists, cell biologists, molecular biologists, and physiologists will find the book invaluable.

Table of Contents

  • List of Contributors



    Mechanisms and Regulation of Protein Turnover

    Factors Involved in the Regulation of Protein Turnover

    Lysosomal Mechanisms of Protein Degradation

    Some Aspects of the Intracellular Breakdown of Exogenous and Endogenous Proteins

    Evidence for a Proton Pump in Rat Liver Lysosomes

    Lysosomal Processing of Intracellular Protein in Rat Liver and Its General Regulation by Amino Acids and Insulin

    In Vivo Determination of Rates of Protein Degradation in Livers of Meal-Fed Rats: Implications of Amino Acid Compartmentation

    The General Characteristics of Intracellular Protein Degradation in Diabetes and Starvation

    The Significance of Protein Degradation in the Regulation of Liver Growth

    Turnover of the Major Proteins of Rat Erythrocytes

    Mode of Degradation of Abnormal Globin Chains in Rabbit Reticulocytes

    Selective Degradation of Abnormal Proteins in Animal and Bacterial Cells

    Mechanisms in Intracellular Turnover of Stable and Labile Enzymes

    Studies on Protein Degradation in Isolated Hepatocytes and Kupffer Cells

    The Chemistry and Turnover of Lysosomal Enzymes

    Genetics of Lysosomal Functions

    Measurement of Protein, Synthesis and Turnover in Animal Cells with Tritiated Water

    Turnover of Soluble Protein in Growing Cultures of Escherichia coli

    Lysosomal and Nonlysosomal Proteases

    Lysosomal Proteinases and Their Specificity

    Control of Proteolysis in Yeast

    Collagenolytic Activity of Lung BANA Hydrolase and Cathepsin B1

    Modification of Fructose 1,6-Bisphosphatase by Lysosomal Proteinases

    Bovine Spleen Cathepsins D and S: Purification, Characterization, and Structural Studies

    Characterization of Two Unique Protease Inhibitors and a Calcium-Activated Protease from Bovine Cardiac Muscle

    Protein Catabolism in Rat Liver Cells

    Uptake of Proteins into the Lysosomal System

    Lysosomal Digestion of Endoctosed Proteins: Opportunities and Problems for the Cell

    Uptake and Degradation of Proteins in Isolated Rat Liver Cells

    Protein Turnover in Isolated Rat Hepatocytes

    Receptor-Mediated Uptake of Macromolecules and Their Delivery to Lysosomes in Human Fibroblasts

    Specific Recognition and Uptake of Lysosomal Enzymes and Modified Glycoproteins by Rat Tissues

    Phosphohexose on Lysosomal Enzymes is the Common Recognition Marker for Pinocytosis Receptor on Fibroblasts

    A Role for Lysosomes in Corpus Luteum Function

    The Use of Lipid Vesticles for Introducing Macromolecules into Cells

    The Inhibitory Effect of 2-Deoxy-D-glucose on Fc and C3b Receptor-Mediated Phagocytosis in Phagocytic Cells

    Protein Turnover in Muscle and Heart

    A Ca2+-Activated Muscle Protease in Myofibrillar Protein Turnover

    Cathepsins B and D: Proteolytic Activity and Ultrastructural Localization in Skeletal Muscle

    Inhibition of Muscle Degeneration Using Protease Inhibitors

    Partial Characterization of a Protease from Cardiac Myofibrils of Dystrophic Hamsters

    Factors Affecting Protein Breakdown in Skeletal Muscle

    Changes in the Turnover Rates of Myosin Heavy Chain and Actin in Cultured Chick Embryo Heart Cells

    Studies on the Regulation of Protein Concentrations in Red and White Skeletal Muscles

    Turnover of Membrane Proteins

    Turnover and Biogenesis of the Plasma Membrane Proteins of Hepatoma Tissue Culture Cells

    A Shuttle between Cell Surface and Lysosomes during Endocytosis

    Turnover of Plasma Membrane Precursor Pools in Virus-Infected and Uninfected HeLa Cells

    Regulation of Insulin and Growth Hormone Receptors in Vitro and in Vivo

    Turnover of Proteins and Glycoproteins of Plasma Membranes in Liver, Regenerating Liver, and Morris Hepatomas

Product details

  • No. of pages: 810
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: January 1, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9781483220192

About the Editors

Harold L. Segal

Darrell J. Doyle

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