This book presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields.

Key Features

Key Features * Basic principles and techniques * Targeting adn sorting sequences * Protein export in bacteria * Membrane protein integration into ER and bacterial membranes * Protein translocation across the ER * Disulfide bond formation in prokaryotes and eukaryotes * Quality control in the export pathway * Import of proteins into organelles * The secretory pathway * Vesicular transport * Spectacular color throughout


Researchers and students interested in all areas of protein science.

Table of Contents

Introduction Overview Methods in Protein Targeting, Translocation and Transport Targeting Sequences Protein Export in Bacteria Protein Sorting at the Membrane of the Endoplasmic Reticulum Membrane Protein Insertion into Bacteial Membranes and Endoplasmic Reticulum Disulfide Bond Formation in Prokaryotes and Eukaryotes The Unfolded Protein Response Protein Quality Control in the Export Pathway: The Endoplasmic Reticulum and its Cytoplasmic Proteasome Connection Translocation of Proteins into Mitochondria The Import and Sorting of Protein into Chloroplasts Import of Proteins into Peroxisomes Nucleocytoplasmic Transport Protein Transport to the Yeast Vacuole The Secretory Pathway Vesicular Transport Conclusion/Perspective


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© 2003
Academic Press
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About the editors

Ross Dalbey

Affiliations and Expertise

Ohio State University, Columbus, U.S.A.

Gunnar von Heijne

Affiliations and Expertise

Stockholm University


"...Dalbey et al. have summed up what has happened so far in a rapidly moving field of modern cellular biochemistry." -EUROPEAN JOURNAL OF CHEMICAL BIOLOGY (2003) "Overall this book provides good summaries of what we know about how proteins are moved between intracellular compartments and how we have studied this problem. Students or anyone wanting to know more about protein trafficking, particularly protein translocation across membranes, will find it a useful guide." —Will Prinz for CELL (November 2002)