This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Biochemists, cell biologists, molecular biologists, biophysicists

Table of Contents


The Enzymology of CAAX Protein Prenylation

I. Abstract

II. Introduction

III. Protein FTase

IV. Protein GGTase-I

V. Conclusions


CAAX Processing and Yeast a-Factor Biogenesis

I. Abstract

II. Introduction

III. The a-Factor Mating Pheromone of S. cerevisiae as an Early Prototype for Dissecting the CAAX-Processing Pathway

IV. Biogenesis Pathway of a-Factor: Genetic and Biochemical Analysis of the a-Factor Machinery

V. Progeria—The Role of Prenylation and ZMPSTE24 in Progeroid Disorders

VI. A Prenylated, Secreted Molecule Involved in Drosophila Germ Cell Migration Requires a Pathway Strikingly Similar to That of a-Factor Biogenesis


Prenylation and Phosphorylation of Ras Superfamily Small GTPases

I. Abstract

II. Introduction

III. Small GTPase Prenylation

IV. C-Terminal Phosphorylation of Prenylated Ras Family Small GTPases

V. C-Terminal Phosphorylation of Prenylated Rho Family Small GTPases

VI. C-Terminal Phosphorylation of Prenylated Rab Family Small GTPases

VII. Conclusions


Biochemical and Biological Functions of Isoprenylcysteine Carboxyl Methyltransferase

I. Abstract

II. Introduction

III. Icmt: Structure and Biological Function

IV. ICMT Substrate Specificity

V. Effect of Methylation by Icmt on Substrate Function: In Vitro Studies

VI. ICMT Effect on Substrate Function: In Vivo Studies

VII. Conclusions

Chemical Probes of Protein Prenylation

I. Abstract

II. Introduction

III. Prenyl Analogs as FTase Inhibitors (FTIs)

IV. Prenyl Analogs as Mechanistic and Structural Probes

V. Substrate Specificity Studies

VI. Prenyl Proteomics Studies

VII. Future


No. of pages:
© 2011
Academic Press
Electronic ISBN:
Print ISBN:

About the serial-volume-editors

Fuyuhiko Tamanoi

Professor Fuyu Tamanoi works at the Dept. of Microbiology, Immunology and Molecular Genetics at the University of California.