Protein Prenylation, Part A - 1st Edition - ISBN: 9780123813398, 9780123813404

Protein Prenylation, Part A, Volume 29

1st Edition

eBook ISBN: 9780123813404
Hardcover ISBN: 9780123813398
Imprint: Academic Press
Published Date: 22nd July 2011
Page Count: 356
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Table of Contents


Protein Prenylation

I. Abstract

II. Steps in the Trail of Research

Insights into the Function of Prenylation from Nuclear Lamin Farnesylation

I. Abstract

II. Introduction

III. Subcellullar Trafficking and Processing of Prelamin A

IV. Step 2 Endoprotease Activity and Zmpste24

V. Functional Aspects of Lamin Farnesylation

VI. Relationship of Lamin Prenylation to the Functional Role of Prenylation in Other Proteins

Posttranslational Processing of Nuclear Lamins

I. Abstract

II. Introduction

III. B-Type Lamins

IV. A-Type Lamins

V. Defects in Prelamin A Processing and Disease

VI. Alternate Prenylation of Prelamin A

VII. The Purpose of Prelamin A Processing

VIII. Concluding Thoughts


Prenylated Proteins in Peroxisome Biogenesis

I. Abstract

II. Peroxisomes

III. Biogenesis of Peroxisomes

Lipid Modification of Ras Superfamily GTPases

I. Abstract

II. Introduction

III. Ras Superfamily Prenyltransferases

IV. Ras Family Members

V. Rho Family Members

VI. Rab Family Members

VII. The Arf Family of Small GTPases

VIII. The Ran Small GTPase

IX. Prenyltransferases as Therapeutic Targets

X. Conclusion


Heterogeneous Prenyl Processing of the Heterotrimeric G protein Gamma Subunits

I. Abstract

II. Heterotrimeric G Proteins and Prenylation of the Gγ Subunit

III. Functional Role of G Protein γ Subunit Prenylation

IV. Variation in Prenyl Processing of Brain G Proteins

V. Conclusion

Farnesylation Versus Geranylgeranylation in G-Protein-Mediated Light Signaling

I. Abstract

II. Introduction

III. Characteristic Properties of Phototransduction in Retinal Rod Cells

IV. Particular Lipidation of Photoreceptor Proteins

V. Biochemical Differences Between Farnesylation and Geranylgeranylation

VI. Physiological Significance of Farnesylation of Gtγ

VII. Biological Significance and Conclusion

Organization and Function of the Rab Prenylation and Recycling Machinery

I. Abstract

II. Rab GTPases

III. Pathways of Rab Prenylation

IV. Organization of the Rab Prenylation Complex and Mechanism of the Prenylation Reaction

V. Structure of the Rab:GDI Complex and Its Functional Segregation from Rab:REP Complex

VI. Extraction of Rab Proteins from Membranes by GDI and REP

VII. Targeting of Rabs to Specific Membranes

VIII. Rab Prenylation in Disease

IX. Conclusions

Protein Prenylation CaaX Processing in Plants

I. Abstract

II. The Plant Protein Prenyltransferase Enzymes

III. FT and GGT-I Substrates in Plants

IV. Protein Prenylation—A Crossroad Between Signaling and Metabolism

V. Prenyltransferase Mutants in Plants

VI. CaaX Processing

VII. Summary


Posttranslational Isoprenylation of Tryptophan Residues in Bacillus subtilis

I. Abstract

II. Quorum Sensing in Bacteria

III. Genetic Competence in B. subtilis

IV. Primary Gene Cluster for ComX Pheromone Production

V. Posttranslational Modification of ComX Pheromone

VI. Structure–Activity Relationships of ComXRO-E-2 Pheromone

VII. Is Posttranslational Isoprenylation of Tryptophan Universal?

VIII. Summary and Future Prospects


Global Analysis of Prenylated Proteins by the Use of a Tagging via Substrate Approach

I. Abstract

II. Introduction

III. General Approach: Tagging via Substrate Approach Utilizing Azide Chemistry

IV. Detection of Farnesylated Proteins

V. Detection of Geranylgeranylated Proteins

VI. Overall Profiles of Farnesylated and Geranylgeranylated Proteins and Further Improvements

VII. Applications of the TAS Methods

VIII. Other Tagging Methods and Toward Constructing Prenylome


Global Identification of Protein Prenyltransferase Substrates

I. Abstract

II. Introduction

III. Methods for Discovering and Predicting Prenyltransferase Substrates

IV. Prenylation in Pathogenic Organisms: Structural and Biochemical Insights

V. Conclusions


Structural Biochemistry of CaaX Protein Prenyltransferases

I. Abstract

II. Protein Farnesyltransferase Structure and Reaction Cycle

III. Protein Geranylgeranyltransferase-I Structure and Reaction Cycle

IV. Determinants of Ca1a2X Substrate Selection in FTase and GGTase-I

V. Structure of Candida albicans Protein Geranylgeranyltransferase-I

VI. Inhibitors of Protein Prenyltransferases as Cancer Chemotherapeutics

VII. FTase Inhibitors for Treatment of Malaria and Other Infectious Diseases

Genetic Analyses of the CAAX Protein Prenyltransferases in Mice

I. Abstract

II. Introduction

III. The Prenyltransferases FTase and GGTase-I

IV. FTase

V. GGTase-I

VI. Simultaneous Inactivation of FTase and GGTase-I

VII. Concluding Remarks

Farnesyl Transferase Inhibitors

I. Abstract

II. Targeting Ras with Farnesyl Transferase Inhibitors

III. Discovery of Farnesyl Transferase Inhibitors

IV. Activity of FTIs in Preclinical Cancer Models and Alternative Prenylation of Ras

V. Impact of FTIs on Other Farnesylated Proteins

VI. Clinical Studies of FTIs in Cancer

VII. Hutchinson–Gilford Progeria Syndrome: A Disease of Farnesylation?

VIII. Conclusions and Other Therapeutic Opportunities for FTIs



This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Biochemists, cell biologists, molecular biologists, biophysicists


No. of pages:
© Academic Press 2011
Academic Press
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews