Protein Phosphorylation in Health and Disease

Protein Phosphorylation in Health and Disease

1st Edition - February 28, 2012
  • Editor: Shirish Shenolikar
  • Hardcover ISBN: 9780123964564
  • eBook ISBN: 9780123964809

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This volume explores some of the most exciting recent advances in basic research on protein phosphorylation in health and disease and how this knowledge is leading to advances in the various fields.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

    1. Wip1 -dependent signaling pathways in health and diseases
      Yun-hua Zhu and Dmitry V. Bulavin
    2. HijAkt: The PI3k/Akt pathway in virus replication and pathogenesis
      Ewan F. Dunn and John H. Connor
    3. Phosphoproteins in stress-induced disease
      Lucy E. Dalton, Eleanor Healey, James Irving & Stefan J. Marciniak
    4. G-substrate: The Cerebellum and Beyond
      Shogo Endo
    5. Targeting Phosphorylation of Eukaryotic Initiation Factor-2a to Treat Human Disease
      Melissa J. Fullwood, Wei Zhou and Shirish Shenolikar
    6. Signaling in striatal neurons: the phosphoproteins of reward, addiction, and dyskinesia
      Jean-Antoine Girault
    7. The Role of Protein Phosphorylation in Therapy-resistance and Disease Progression in Chronic Myelogenous Leukemia
      Wen Chun JUAN and S. Tiong ONG
    8. Phosphatases driving mitosis: pushing the gas and lifting the brakes
      Erika Segear Johnson and Sally Kornbluth
    9. Protein tyrosine phosphatases in cancer: Friends and Foes
      David P. Labbé, Serge Hardy, Michel L. Tremblay
    10. Multiple Roles Of Stat3 In Cardiovascular Inflammatory Responses
      Cheh Peng Lim and Xin-Yuan Fu
    11. PAKs in human disease
      Perry M. Chan and Ed Manser
    12. Protein Phosphatases and Alzheimer’s Disease
      Steven P. Braithwaite, Jeffry B. Stock, Paul J. Lombroso, Angus C. Nairn
    13. Role of the JNK pathway in human diseases
      Kanaga Sabapathy
    14. Mass spectrometric tools for systematic analysis of protein phosphorylation
      Nicole St-Denis1 and Anne-Claude Gingras

Product details

  • No. of pages: 446
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: February 28, 2012
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123964564
  • eBook ISBN: 9780123964809

About the Serial Volume Editor

Shirish Shenolikar

Affiliations and Expertise

Durham, North Carolina, U.S.A.