This volume explores some of the most exciting recent advances in basic research on protein phosphorylation in health and disease and how this knowledge is leading to advances in the various fields.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  1. Wip1 -dependent signaling pathways in health and diseases
    Yun-hua Zhu and Dmitry V. Bulavin
  2. HijAkt: The PI3k/Akt pathway in virus replication and pathogenesis
    Ewan F. Dunn and John H. Connor
  3. Phosphoproteins in stress-induced disease
    Lucy E. Dalton, Eleanor Healey, James Irving & Stefan J. Marciniak
  4. G-substrate: The Cerebellum and Beyond
    Shogo Endo
  5. Targeting Phosphorylation of Eukaryotic Initiation Factor-2a to Treat Human Disease
    Melissa J. Fullwood, Wei Zhou and Shirish Shenolikar
  6. Signaling in striatal neurons: the phosphoproteins of reward, addiction, and dyskinesia
    Jean-Antoine Girault
  7. The Role of Protein Phosphorylation in Therapy-resistance and Disease Progression in Chronic Myelogenous Leukemia
    Wen Chun JUAN and S. Tiong ONG
  8. Phosphatases driving mitosis: pushing the gas and lifting the brakes
    Erika Segear Johnson and Sally Kornbluth
  9. Protein tyrosine phosphatases in cancer: Friends and Foes
    David P. Labbé, Serge Hardy, Michel L. Tremblay
  10. Multiple Roles Of Stat3 In Cardiovascular Inflammatory Responses
    Cheh Peng Lim and Xin-Yuan Fu
  11. PAKs in human disease
    Perry M. Chan and Ed Manser
  12. Protein Phosphatases and Alzheimer’s Disease
    Steven P. Braithwaite, Jeffry B. Stock, Paul J. Lombroso, Angus C. Nairn
  13. Role of the JNK pathway in human diseases
    Kanaga Sabapathy
  14. Mass spectrometric tools for systematic analysis of protein phosphorylation
    Nicole St-Denis1 and Anne-Claude Gingras


No. of pages:
© 2012
Academic Press
Print ISBN:
Electronic ISBN:


Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal