Protein Misassembly - 1st Edition - ISBN: 9780120342501, 9780080582238

Protein Misassembly, Volume 50

1st Edition

Serial Editors: Frederic Richards David Eisenberg Peter Kim
Serial Volume Editors: Ronald Wetzel
eBook ISBN: 9780080582238
Imprint: Academic Press
Published Date: 8th October 1997
Page Count: 282


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Table of Contents

R. Jaenicke and R. Seckler, Protein Misassembly in Vitro.

M.P. Schlunegger, M.J. Bennett, and D. Eisenberg, Oligomer Formation by 3D Domain Swapping: A Model for Protein Assembly and Misassembly.

M. Sunde and C. Blake, The Structure of Amyloid Fibrils by Electron Microscopy and X-Ray Diffraction.

W. Colon, Z. Lai, H.A. Lashuel, J. McCulloch, S.L. McCutchen, G.J. Miroy, S.A. Peterson, and J.W. Kelly, Transthyretin Quaternary and Tertiary Structural Changes Facilitate Misassembly into Amyloid.

R. Wetzel, Domain Stability in Immunoglobulin Light Chain Deposition Disorders.

S. Betts, C. Haase-pettingel, and J. King, Mutational Effects on Inclusion Body Formation. Author Index. Subject Index.


The role that primary amino acid sequences plays in influencing the partitioning of polypeptides between productive folding and irreversible aggregation pathways has introduced a whole new dimension to the folding problem. The volume deals with the structures of the products of protein misassembly and the role of amino acid sequences in favoring these structures.


Molecular biologists, biochemists, immunologists, and biophysicists.


No. of pages:
© Academic Press 1997
Academic Press
eBook ISBN:


@qu:"The authority, originality, and editing of the reviews are first class." @source:--NATURE @qu:"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists." @source:--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY @qu:"...this book provides a revealing and up-to-date look at many aspects of protein aggregation and amyloid fibril formation...will be invaluable for anyone, and especially newcomers interested in the structure of amyloid and its molecular basis." @source:—Anthony L. Fink, Ph.D., University of California, Santa Cruz, in AMYLOID (1999)

About the Serial Editors

Frederic Richards Serial Editor

Affiliations and Expertise

Yale University, New Haven, Connecticut, U.S.A.

David Eisenberg Serial Editor

Affiliations and Expertise

University of California, Los Angeles, U.S.A.

Peter Kim Serial Editor

Affiliations and Expertise

Massachusetts Institute of Technology, Whitehead Institute for Biomedical Research, Howard Hughes Medical Institute Research Laboratories, Cambridge, U.S.A.

About the Serial Volume Editors

Ronald Wetzel Serial Volume Editor

Affiliations and Expertise

University of Tennessee Medical Center, Knoxville, U.S.A.