Protein Misassembly, Volume 50

1st Edition

Print ISBN: 9780120342501
eBook ISBN: 9780080582238
Imprint: Academic Press
Published Date: 8th October 1997
Page Count: 282


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The role that primary amino acid sequences plays in influencing the partitioning of polypeptides between productive folding and irreversible aggregation pathways has introduced a whole new dimension to the folding problem. The volume deals with the structures of the products of protein misassembly and the role of amino acid sequences in favoring these structures.


Molecular biologists, biochemists, immunologists, and biophysicists.

Table of Contents

R. Jaenicke and R. Seckler, Protein Misassembly in Vitro.

M.P. Schlunegger, M.J. Bennett, and D. Eisenberg, Oligomer Formation by 3D Domain Swapping: A Model for Protein Assembly and Misassembly.

M. Sunde and C. Blake, The Structure of Amyloid Fibrils by Electron Microscopy and X-Ray Diffraction.

W. Colon, Z. Lai, H.A. Lashuel, J. McCulloch, S.L. McCutchen, G.J. Miroy, S.A. Peterson, and J.W. Kelly, Transthyretin Quaternary and Tertiary Structural Changes Facilitate Misassembly into Amyloid.

R. Wetzel, Domain Stability in Immunoglobulin Light Chain Deposition Disorders.

S. Betts, C. Haase-pettingel, and J. King, Mutational Effects on Inclusion Body Formation. Author Index. Subject Index.


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© Academic Press 1997
Academic Press
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@qu:"The authority, originality, and editing of the reviews are first class." @source:--NATURE @qu:"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists." @source:--JOURNAL OF THE AMERICAN CHEMICAL SOCIETY @qu:"...this book provides a revealing and up-to-date look at many aspects of protein aggregation and amyloid fibril formation...will be invaluable for anyone, and especially newcomers interested in the structure of amyloid and its molecular basis." @source:—Anthony L. Fink, Ph.D., University of California, Santa Cruz, in AMYLOID (1999)