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Description
This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to the study of protein structure and function as well as proteomics.
It is a definite must-have work for:
- libraries at academic institutions with Master and Graduate programs in biochemistry, molecular biology, structural biology and proteomics
- individual laboratories with interests covering these areas
- libraries and individual laboratories in the pharmaceutical and biotechnology industries.
Key Features
*Serves as an essential reference to those working in the field
*Incorporates the contributions of prominent experts
*Features comprehensive coverage and a logical structure
Readership
Graduate students, researchers and professionals interested in mass spectrometry as it relates to study of protein structure and function as well as proteomics.
Table of Contents
Foreword
Chapter 1. An Introduction to the Basic Principles and Concepts of Mass Spectrometry
Kym Faull, Alek N. Dooley, Frederic Halgand, Lorelei Shoemaker, Andrew J. Norris, Christopher M. Ryan, Arthur Laganowsky, Jodie V. Johnson and Jonathan E. Katz
Chapter 2. Charaterization of protein conformation and dynamics with ESI MS
Igor Kaltashov and Wendell P. Griffith
Chapter 3. An Introduction to Ion Mobility and Mass Spectrometry of Non-Covalent Protein Complexes Summer Bernstein, and Michael Bowers
Chapter 4. Study of protein structure using hydrogen-deuterium exchange
Jennifer L. Mitchell and John R. Engen
Chapter 5. Stopped flow analysis with MS
Lars Konermann, Jingxi Pan, and Derek J. Wilson
Chapter 6. SUPREX; Stability of Unpurified Proteins by Rates of H/D Exchange
Michael C. Fitzgerald, Liangjie Tang, and Erin D. Hopper
Chapter 7. Microsecond time-scale hydroxyl radical profiling of solvent-accessible protein residues
David Hambly and Michael Gross
Chapter 8. Intact Protein Mass Measurements and Top-Down Mass Spectrometry: Application to Integral Membrane Proteins.
Julian P. Whitelegge
Chapter 9. Analysis of dynamic membrane protein structure-function relationships using chemical modification techniques and mass spectrometry
Adam B. Weinglass,
Chapter 10. Shotgun approaches to membrane protein structure and topology
Anna E. Speers and Christine Wu
Chapter 11. Covalent trapping of protein interactions in complex systems
Rasanjala Weerasekera, Tujin Shi and Gerold Schmitt-Ulms
Chapter 12. Phosphoproteomics
Martin R. Larsen and Phillip J. Robinson
Chapter 13. Detection of tyrosine phosphorylation sites by mass spectrometry
Guoan Zhang, Cho
Details
- No. of pages:
- 552
- Language:
- English
- Copyright:
- © 2009
- Published:
- 2nd September 2008
- Imprint:
- Elsevier Science
- eBook ISBN:
- 9780080932033
- Print ISBN:
- 9780444530554
About the editor
Reviews
"I found the volume 52 of the Comprehensive Analytical Chemistry series (D. Barceló, Editor) entitled Protein Mass Spectrometry and edited by J. P. Whitelegge to be a current, informative, and interesting publication. I recommend this book both to colleagues, who study proteins and have questions, and to fellow mass spectrometrists for whom looking for answers is a favorite past time."--Journal of the American Society for Mass Spectrometry