Protein Mass Spectrometry

Protein Mass Spectrometry

1st Edition - September 2, 2008

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  • Editor: Julian Whitelegge
  • eBook ISBN: 9780080932033
  • Hardcover ISBN: 9780444530554

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This book is designed to be a central text for young graduate students interested in mass spectrometry as it relates to the study of protein structure and function as well as proteomics. It is a definite must-have work for:- libraries at academic institutions with Master and Graduate programs in biochemistry, molecular biology, structural biology and proteomics- individual laboratories with interests covering these areas - libraries and individual laboratories in the pharmaceutical and biotechnology industries.

Key Features

*Serves as an essential reference to those working in the field
*Incorporates the contributions of prominent experts
*Features comprehensive coverage and a logical structure


Graduate students, researchers and professionals interested in mass spectrometry as it relates to study of protein structure and function as well as proteomics.

Table of Contents

  • Foreword
    Chapter 1. An Introduction to the Basic Principles and Concepts of Mass Spectrometry
    Kym Faull, Alek N. Dooley, Frederic Halgand, Lorelei Shoemaker, Andrew J. Norris, Christopher M. Ryan, Arthur Laganowsky, Jodie V. Johnson and Jonathan E. Katz
    Chapter 2. Charaterization of protein conformation and dynamics with ESI MS
    Igor Kaltashov and Wendell P. Griffith
    Chapter 3. An Introduction to Ion Mobility and Mass Spectrometry of Non-Covalent Protein Complexes Summer Bernstein, and Michael Bowers
    Chapter 4. Study of protein structure using hydrogen-deuterium exchange
    Jennifer L. Mitchell and John R. Engen
    Chapter 5. Stopped flow analysis with MS
    Lars Konermann, Jingxi Pan, and Derek J. Wilson
    Chapter 6. SUPREX; Stability of Unpurified Proteins by Rates of H/D Exchange
    Michael C. Fitzgerald, Liangjie Tang, and Erin D. Hopper
    Chapter 7. Microsecond time-scale hydroxyl radical profiling of solvent-accessible protein residues
    David Hambly and Michael Gross
    Chapter 8. Intact Protein Mass Measurements and Top-Down Mass Spectrometry: Application to Integral Membrane Proteins.
    Julian P. Whitelegge
    Chapter 9. Analysis of dynamic membrane protein structure-function relationships using chemical modification techniques and mass spectrometry
    Adam B. Weinglass,
    Chapter 10. Shotgun approaches to membrane protein structure and topology
    Anna E. Speers and Christine Wu
    Chapter 11. Covalent trapping of protein interactions in complex systems
    Rasanjala Weerasekera, Tujin Shi and Gerold Schmitt-Ulms
    Chapter 12. Phosphoproteomics
    Martin R. Larsen and Phillip J. Robinson
    Chapter 13. Detection of tyrosine phosphorylation sites by mass spectrometry
    Guoan Zhang, Chongfeng Xu and Thomas A. Neubert
    Chapter 14. Histidine Phosphorylation
    Xin-Lin Zu, Paul G. Besant and Paul V. Attwood
    Chapter 15. O-glcnac modification of proteins
    Robert J. Chalkley, Lance Wells and Keith Vosseller
    Chapter 16. Analysis of Deamidation in Proteins
    Jason J. Cournoyer and Peter B. O’Connor
    Chapter 17. Quantitative Proteomics
    Silke Oeljeklaus, Jon Barbour and Bettina Warscheid
    Chapter 18. Multiplexed Quantitative Proteomics using Mass Spectrometry
    Philip L. Ross, Xunming Chen, Esteban Toro, Leticia Britos, Lucy Shapiro, Darryl Pappin
    Chapter 19. Large-scale subcellular localization of proteins by protein correlation profiling.
    Leonard J. Foster
    Chapter 20. Accuracy of Quantitation from Full and Partial Metabolic Labeling Experiments
    Edward L. Huttlin, Adrian D. Hegeman and Michael R. Sussman, Ph.D.

Product details

  • No. of pages: 552
  • Language: English
  • Copyright: © Elsevier Science 2008
  • Published: September 2, 2008
  • Imprint: Elsevier Science
  • eBook ISBN: 9780080932033
  • Hardcover ISBN: 9780444530554

About the Editor

Julian Whitelegge

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