Protein Kinases in Development and Disease - 1st Edition - ISBN: 9780128015131, 9780128016244

Protein Kinases in Development and Disease, Volume 123

1st Edition

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Series Volume Editors: Andreas Jenny
Hardcover ISBN: 9780128015131
eBook ISBN: 9780128016244
Imprint: Academic Press
Published Date: 22nd February 2017
Page Count: 498
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Table of Contents

Chapter One: WNK Kinases in Development and Disease

  • Abstract
  • 1 Introduction
  • 2 The WNK-SPAK/OSR1 Kinase Cascade: Roles in Physiology and Disease
  • 3 Emerging Functions of the WNK Signaling Axis in Development
  • 4 Functions of WNKs in Cancer
  • 5 Conclusions
  • Acknowledgments

Chapter Two: SGK1: The Dark Side of PI3K Signaling

  • Abstract
  • 1 Introduction: The Glucocorticoid-Regulated Kinase Family
  • 2 SGK1: Expression and Stability Control
  • 3 SGK1 Is Activated in a PI3K-Dependent Manner
  • 4 AKT and SGK1: Target Overlap and Selectivity
  • 5 Roadblocks to Defining Specific SGK1 Functions
  • 6 SGK1 in Development and Differentiation
  • 7 SGK1 and Cancer
  • 8 Concluding Remarks
  • Acknowledgments

Chapter Three: Homeodomain-Interacting Protein Kinases: Diverse and Complex Roles in Development and Disease

  • Abstract
  • 1 Introduction
  • 2 Requirements for Hipk Proteins During Development
  • 3 Hipk Roles in Regulation of Diverse Signaling Pathways
  • 4 Regulation of Hipk Activity
  • 5 Hipks in Disease
  • 6 Conclusions
  • Acknowledgments

Chapter Four: ROR-Family Receptor Tyrosine Kinases

  • Abstract
  • 1 Domain Architecture and Expression Patterns
  • 2 ROR Function as a WNT Receptor and Its Role in WNT Signal Transduction
  • 3 Human Inheritable Syndromes Caused by ROR2 Mutation
  • 4 The Role of ROR-Family RTKs in Embryonic Development

Chapter Five: Regulation of Drosophila Development by the Golgi Kinase Four-Jointed

  • Abstract
  • 1 Introduction
  • 2 Genetic and Molecular Identification of Drosophila Four-Jointed
  • 3 The Fat/Dachsous/Four-Jointed Pathway
  • 4 Biochemical Characterization of Fj
  • 5 Modulation of Fat-Ds Binding by Fj
  • 6 Fj Polarizes Fat Activity
  • 7 Vertebrate Four-Jointed, Fat, Dachsous, and Other Kinases in the Secretory Pathway
  • 8 Conclusion
  • Acknowledgments

Chapter Six: The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease

  • Abstract
  • 1 Introduction
  • 2 The Highly Conserved Core Kinase Cassette
  • 3 The Hippo Pathway Restricts Mass Accumulation and Proliferation
  • 4 The Hippo Pathway Regulates Apoptosis
  • 5 The Hippo Pathway Restricts Organ Size and Maintains Organ Homeostasis
  • 6 Molecular Mechanisms and Additional Roles of the Hippo Pathway: Posttranslational Targets and Transcriptional Outputs
  • 7 Upstream Signals and Regulators and Mechanisms of Pathway Homeostasis
  • 8 Dysregulation of the Hippo Pathway in Disease
  • 9 Conclusions and Open Questions
  • Acknowledgments

Chapter Seven: Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor

  • Abstract
  • 1 Introduction
  • 2 The CSF-1R in Mononuclear Phagocyte Development
  • 3 CSF-1-Regulated Macrophages in Tissue Morphogenesis and Organismal Growth
  • 4 Regulation of Osteoclasts and Bone Development by CSF-1
  • 5 Direct Regulation of Nonhematopoietic Cells by the CSF-1R
  • 6 Conclusions
  • Acknowledgments

Chapter Eight: Glycogen Synthase Kinase 3: A Kinase for All Pathways?

  • Abstract
  • 1 The Early Years
  • 2 GSK-3 Isoforms, Orthologues, and Expression
  • 3 GSK-3 Structure
  • 4 Regulation
  • 5 Signaling Infidelity
  • 6 So How Is Specificity Achieved?
  • 7 Lessons From GSK-3 KO Mice
  • 8 Therapeutic Perspectives
  • 9 Conclusions and Perspectives
  • Acknowledgments

Chapter Nine: CK1 in Developmental Signaling: Hedgehog and Wnt

  • Abstract
  • 1 Introduction
  • 2 CK1 in the Regulation of Hh Pathway
  • 3 CK1 in Wnt Signaling
  • 4 Regulation of CK1 in Hh and Wnt Signaling
  • 5 Conclusion
  • Acknowledgments

Chapter Ten: Ligand Receptor-Mediated Regulation of Growth in Plants

  • Abstract
  • 1 Introduction
  • 2 Novel and Unique Plant Signaling Pathways
  • 3 Plasma Membrane as the Site of Peptide Ligand Sensing by Receptors
  • 4 FERONIA and Its Gene Family in Plant Growth and Development
  • 5 Organ Size and Growth Are Determined by Stimulation and Inhibition by Signaling Pathways in Plants and Animals
  • 6 RALF Family and Function in Plant Growth and Development
  • 7 RALF-Like Peptides Are Not Only Produced by Plants But Also by Pathogenic Microbes
  • 8 Other Endogenous Hormone-Like Peptides and Their Receptor Pairs for Plant Growth, Development, and Physiology
  • 9 Conclusion and Future Perspectives

Chapter Eleven: Regulation of Cell Polarity by PAR-1/MARK Kinase

  • Abstract
  • 1 Introduction
  • 2 Structure and Regulation of PAR-1/MARK Kinases
  • 3 Regulation of Cell Polarity by the PAR Proteins
  • 4 Asymmetric Division of the C. elegans Zygote
  • 5 Establishment of the Anterior/Posterior Axis During Drosophila Oogenesis
  • 6 MARK Kinases and Neurogenesis
  • 7 PAR-1 and Disease
  • 8 Concluding Remarks

Chapter Twelve: Receptor Tyrosine Kinases and Phosphatases in Neuronal Wiring: Insights From Drosophila

  • Abstract
  • 1 Introduction
  • 2 Model Circuits Used to Study the Genetic Control of Neuronal Wiring in Drosophila
  • 3 Receptor Tyrosine Kinase
  • 4 Receptor Protein Tyrosine Phosphatases
  • 5 Future Directions
  • 6 Conclusions
  • Acknowledgments

Chapter Thirteen: VEGF Receptor Tyrosine Kinases: Key Regulators of Vascular Function

  • Abstract
  • 1 Introduction
  • 2 Structure and Function of VEGFRs
  • 3 An Evolutionary Perspective on VEGFR Function
  • 4 Neuropilins: Coreceptors Modulating VEGFR Signaling
  • 5 VEGFR Ligands
  • 6 Perspective
  • Acknowledgments


Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease.

Key Features

  • Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms
  • Includes a broad scope of topics that are addressed
  • Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge


Graduate students, postdocs and established scientists in developmental, molecular, and cell biology. Also, anyone in these fields who aims to get both a conceptual overview of new developments or an up-to-date review of the literature about well known and less well known kinases.


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© Academic Press 2017
22nd February 2017
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Series Volume Editors

Andreas Jenny Series Volume Editor

Andreas Jenny currently is Associate Professor in the departments of Developmental and Molecular Biology and Genetics at the Albert Einstein College of Medicine in New York. He received his PhD from the University of Basel, Switzerland for his work on mRNA 3’end processing with Dr. W. Keller. He then joined the lab of Dr. Anne Ephrussi at the EMBL in Heidelberg to study how mRNA localization leads to embryonic axis determination. In Anne’s lab, he realized how great Drosophila is to address fundamental questions of development. While in the lab of Dr. Marek Mlodzik at Mount Sinai in New York, Dr. Jenny started to combine molecular in vitro and genetic in vivo approaches to study the regulation of the canonical and non-canonical Wnt pathways. His own lab at Einstein focuses on kinases that regulate Wnt signaling and mediate its interactions with the cytoskeleton. More recently the Jenny lab also became interested in autophagy with the overarching goal to use Drosophila as model system to address fundamental questions that are relevant for development and disease in general.

Affiliations and Expertise

Department of Developmental and Molecular Biology, Department of Genetics, Albert Einstein College of Medicine, USA