Chapter One: WNK Kinases in Development and Disease
- Abstract
- 1 Introduction
- 2 The WNK-SPAK/OSR1 Kinase Cascade: Roles in Physiology and Disease
- 3 Emerging Functions of the WNK Signaling Axis in Development
- 4 Functions of WNKs in Cancer
- 5 Conclusions
- Acknowledgments
Chapter Two: SGK1: The Dark Side of PI3K Signaling
- Abstract
- 1 Introduction: The Glucocorticoid-Regulated Kinase Family
- 2 SGK1: Expression and Stability Control
- 3 SGK1 Is Activated in a PI3K-Dependent Manner
- 4 AKT and SGK1: Target Overlap and Selectivity
- 5 Roadblocks to Defining Specific SGK1 Functions
- 6 SGK1 in Development and Differentiation
- 7 SGK1 and Cancer
- 8 Concluding Remarks
- Acknowledgments
Chapter Three: Homeodomain-Interacting Protein Kinases: Diverse and Complex Roles in Development and Disease
- Abstract
- 1 Introduction
- 2 Requirements for Hipk Proteins During Development
- 3 Hipk Roles in Regulation of Diverse Signaling Pathways
- 4 Regulation of Hipk Activity
- 5 Hipks in Disease
- 6 Conclusions
- Acknowledgments
Chapter Four: ROR-Family Receptor Tyrosine Kinases
- Abstract
- 1 Domain Architecture and Expression Patterns
- 2 ROR Function as a WNT Receptor and Its Role in WNT Signal Transduction
- 3 Human Inheritable Syndromes Caused by ROR2 Mutation
- 4 The Role of ROR-Family RTKs in Embryonic Development
Chapter Five: Regulation of Drosophila Development by the Golgi Kinase Four-Jointed
- Abstract
- 1 Introduction
- 2 Genetic and Molecular Identification of Drosophila Four-Jointed
- 3 The Fat/Dachsous/Four-Jointed Pathway
- 4 Biochemical Characterization of Fj
- 5 Modulation of Fat-Ds Binding by Fj
- 6 Fj Polarizes Fat Activity
- 7 Vertebrate Four-Jointed, Fat, Dachsous, and Other Kinases in the Secretory Pathway
- 8 Conclusion
- Acknowledgments
Chapter Six: The Hippo Pathway: A Master Regulatory Network Important in Development and Dysregulated in Disease
- Abstract
- 1 Introduction
- 2 The Highly Conserved Core Kinase Cassette
- 3 The Hippo Pathway Restricts Mass Accumulation and Proliferation
- 4 The Hippo Pathway Regulates Apoptosis
- 5 The Hippo Pathway Restricts Organ Size and Maintains Organ Homeostasis
- 6 Molecular Mechanisms and Additional Roles of the Hippo Pathway: Posttranslational Targets and Transcriptional Outputs
- 7 Upstream Signals and Regulators and Mechanisms of Pathway Homeostasis
- 8 Dysregulation of the Hippo Pathway in Disease
- 9 Conclusions and Open Questions
- Acknowledgments
Chapter Seven: Regulation of Embryonic and Postnatal Development by the CSF-1 Receptor
- Abstract
- 1 Introduction
- 2 The CSF-1R in Mononuclear Phagocyte Development
- 3 CSF-1-Regulated Macrophages in Tissue Morphogenesis and Organismal Growth
- 4 Regulation of Osteoclasts and Bone Development by CSF-1
- 5 Direct Regulation of Nonhematopoietic Cells by the CSF-1R
- 6 Conclusions
- Acknowledgments
Chapter Eight: Glycogen Synthase Kinase 3: A Kinase for All Pathways?
- Abstract
- 1 The Early Years
- 2 GSK-3 Isoforms, Orthologues, and Expression
- 3 GSK-3 Structure
- 4 Regulation
- 5 Signaling Infidelity
- 6 So How Is Specificity Achieved?
- 7 Lessons From GSK-3 KO Mice
- 8 Therapeutic Perspectives
- 9 Conclusions and Perspectives
- Acknowledgments
Chapter Nine: CK1 in Developmental Signaling: Hedgehog and Wnt
- Abstract
- 1 Introduction
- 2 CK1 in the Regulation of Hh Pathway
- 3 CK1 in Wnt Signaling
- 4 Regulation of CK1 in Hh and Wnt Signaling
- 5 Conclusion
- Acknowledgments
Chapter Ten: Ligand Receptor-Mediated Regulation of Growth in Plants
- Abstract
- 1 Introduction
- 2 Novel and Unique Plant Signaling Pathways
- 3 Plasma Membrane as the Site of Peptide Ligand Sensing by Receptors
- 4 FERONIA and Its Gene Family in Plant Growth and Development
- 5 Organ Size and Growth Are Determined by Stimulation and Inhibition by Signaling Pathways in Plants and Animals
- 6 RALF Family and Function in Plant Growth and Development
- 7 RALF-Like Peptides Are Not Only Produced by Plants But Also by Pathogenic Microbes
- 8 Other Endogenous Hormone-Like Peptides and Their Receptor Pairs for Plant Growth, Development, and Physiology
- 9 Conclusion and Future Perspectives
Chapter Eleven: Regulation of Cell Polarity by PAR-1/MARK Kinase
- Abstract
- 1 Introduction
- 2 Structure and Regulation of PAR-1/MARK Kinases
- 3 Regulation of Cell Polarity by the PAR Proteins
- 4 Asymmetric Division of the C. elegans Zygote
- 5 Establishment of the Anterior/Posterior Axis During Drosophila Oogenesis
- 6 MARK Kinases and Neurogenesis
- 7 PAR-1 and Disease
- 8 Concluding Remarks
Chapter Twelve: Receptor Tyrosine Kinases and Phosphatases in Neuronal Wiring: Insights From Drosophila
- Abstract
- 1 Introduction
- 2 Model Circuits Used to Study the Genetic Control of Neuronal Wiring in Drosophila
- 3 Receptor Tyrosine Kinase
- 4 Receptor Protein Tyrosine Phosphatases
- 5 Future Directions
- 6 Conclusions
- Acknowledgments
Chapter Thirteen: VEGF Receptor Tyrosine Kinases: Key Regulators of Vascular Function
- Abstract
- 1 Introduction
- 2 Structure and Function of VEGFRs
- 3 An Evolutionary Perspective on VEGFR Function
- 4 Neuropilins: Coreceptors Modulating VEGFR Signaling
- 5 VEGFR Ligands
- 6 Perspective
- Acknowledgments