Protein Kinase Inhibitors in Research and Medicine, Part B - 1st Edition - ISBN: 9780123979438, 9780123984616

Protein Kinase Inhibitors in Research and Medicine, Part B, Volume 548

1st Edition

Serial Volume Editors: Kevan Shokat
eBook ISBN: 9780123984616
Hardcover ISBN: 9780123979438
Imprint: Academic Press
Published Date: 1st December 2014
Page Count: 496
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Table of Contents

  1. Catalytic Mechanisms and Regulation of Protein Kinases
    2. The resistance tetrad: amino acid hotspots for kinome-wide design and exploitation of drug-resistant protein kinase alleles
    3. Fragment-based approaches to the discovery of kinase inhibitors
    4. FLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase ConformationsFLiK: A Direct Binding Assay for the Identification and Kinetic Characterization of Stabilizers of Inactive Kinase Conformations
    5. The Logic and Design of Analog-sensitive (AS) Kinases and their Small Molecule Inhibitors
    6. A Structural Atlas of Kinases Inhibited by Clinically Approved Drugs
    7. Targeting Protein Kinases with Selective and Semi-Promiscuous Covalent Inhibitors
    8. Discovery of Allosteric Bcr-Abl inhibitors from Phenotypic Screen to Clinical Candidate

Description

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.

Key Features

  • Second of two volumes focusing on protein kinase inhibitors in research and medicine
  • Part of the Methods in Enzymology serial with authors who are experts in their disciplines

Readership

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists


Details

No. of pages:
496
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780123984616
Hardcover ISBN:
9780123979438

About the Serial Volume Editors

Kevan Shokat Serial Volume Editor

Affiliations and Expertise

Department Cellular and Molecular Pharmacology, University of California San Francisco, CA, USA