Description

This volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds

Key Features

  • Chapters provide an invaluable resource for academics, researchers and students alike.
  • Iinternational board of authors.
  • This volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds
  • Readership

    Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

    Table of Contents

    1. Simplified Synthetic Antibody Libraries
    2. Saravanan Rajan and Sachdev S. Sidhu

    3. Generation of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting
    4. Jijie Gu and Tariq Ghayur

    5. Discovery of internalizing antibodies to tumor antigens from phage libraries
    6. Yu Zhou and James D Marks

    7. Optimizing properties of anti-receptor antibodies using kinetic computational models and experiments
    8. Brian D. Harms, Jeffrey D. Kearns, Stephen V. Su, Neeraj Kohli, Ulrik B. Nielsen and Birgit Schoeberl

    9. Cell-specific siRNA delivery by peptides and antibodies
    10. Sang-Kyung Lee, Alyssa Siefert, Jagadish Beloor, Tarek M Fahmy and Priti Kumar

    11. Conjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues
    12. Robert P. Lyon*, David L. Meyer, Jocelyn R. Setter, and Peter D. Senter

    13. Building and characterizing antibody-targeted lipidic nanotherapeutics
    14. Dmitri B. Kirpotin, Charles O. Noble, Mark E. Hayes, Zhaohua Huang, Tad Kornaga, Yu Zhou, Ulrik B. Nielsen, James D. Marks, and Daryl C. Drummond

    15. Cell-Targeting Fusion Constructs Containing Recombinant Gelonin
    16. Mi-Ae Lyu; Yu (Joshua) Cao; Khalid A. Mohamedali; and Michael G. Rosenblum

    17. Stapled Peptides for Intracellular Drug Targets
    18. Gregory L. Verdine andGerard J. Hilinski

    19. Mapping of vascular zip codes by phage display
    20. Tambet Teesalu, Kazuki N. Sugahara & Erkki Ruoslahti

    21. Engineering cyclic peptide toxins
    22. Richard J. Clark and David J. Craik

    23. Peptide Discovery using Bacterial Display and Flow Cytometry
    24. Jennifer A. Getz, Tobias D. Schoep, Patrick S. Daugherty

    25. Oral enzyme therapy for celiac sprue
    26. Mic

    Details

    No. of pages:
    392
    Language:
    English
    Copyright:
    © 2012
    Published:
    Imprint:
    Academic Press
    Print ISBN:
    9780124160392
    Electronic ISBN:
    9780123914743