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Protein Biosynthesis Interference in Disease - 1st Edition - ISBN: 9780128234853

Protein Biosynthesis Interference in Disease

1st Edition

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Author: Elena Paley
Paperback ISBN: 9780128234853
Imprint: Academic Press
Published Date: 2nd November 2020
Page Count: 296
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Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer’s and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand the underlying factors of protein disease and improve patient outcomes.

Key Features

  • Enables biochemists, molecular biologists and disease researchers to advance disease prevention, laboratory testing, and treatment pathways for protein biosynthesis interference related disorders
  • Examines the biochemical and molecular basis of protein biosynthesis interference in neurodegenerative disorders, cancer and inflammatory conditions, among other diseases
  • Analyzes tryptamine, biogenic amines, and aminoacyl-tRNA synthetases dynamics in protein translation and possible treatment pathways regulating protein biosynthesis


Active researchers and students of biochemistry, molecular biology, cellular biology, neuroscience, protein biochemistry, and nutrition. Clinicians and students of life science and medicine

Table of Contents

Chapter 1. Introduction

Chapter 2. Tryptamine in the diet, human microbiome, tRNA aminoacylation-protein biosynthesis, host-microbiota metabolic interactions

Chapter 3. Dimethyltryptamine, methyltryptamine, hallucinations and metals

Chapter 4. Psychoactive effects and toxicity of tryptamine, N-methyltryptamine (NMT) and N, N-dimethyltryptamine (DMT): quantification methods

Chapter 5. Tryptamine in renal pathologies and in pregnancy

Chapter 6. Tryptophanyl-tRNA synthetase (TrpRS) inhibition or TrpRS gene (WARS) mutations and deletion result to TrpRS deficiency and pathologies

Chapter 7. Tryptamine in liver diseases and alcohol abuse

Chapter 8. Tryptamine and tyramine in tobacco smoking

Chapter 9. Tryptamine and other biogenic amines in human vaginal samples

Chapter 10. Tryptamine and tryptophan in human fecal samples: diet alters tryptamine levels

Chapter 11. Tryptamine in human noncataractous and cataractous eye lenses

Chapter 12. Tryptamine toxicity in rats, adrenalectomy, toxicity prevention

Chapter 13. Microorganisms: the natural producers of tryptamine in food

Chapter 14. Human gut bacterial sequence associated with Alzheimer’s disease and biogenic amines

Chapter 15. Disease, factors and condition associated with Alzheimer’s disease (AD) and dementia support a concept that AD is a widespread systemic disorder

Chapter 16. Arterial hypertension in comorbidity in dementia and Alzheimer’s disease, tryptamine in metabolic syndrome

Chapter 17. Whole blood viscosity: biogenic amines, dementia and Alzheimer’s disease

Chapter 18. Tryptamine and aminoacyl-tRNAs in sleep-wake and circadian disruptions

Chapter 19. Senile plaques and/or neurofibrillary tangles in brain of non-demented individuals

Chapter 20. Historical perspectives and future research directions

Chapter 21. Tryptamine content and effects in humans and animals

Chapter 22. Link protein half-lives to neurodegeneration: tryptamine treatment effects

Chapter 23. Alzheimer’s disease human gut microbiome associated sequence (ADAS): predictive disease modeling with ADAS: generating ADAS variants from human samples

Chapter 24. Tryptamine and other biogenic amines (BA) as modified and degradable factors

Chapter 25. Tryptamine and TrpRS in cancer and other conditions

Chapter 26. Experimental procedures: tryptophanyl-tRNA synthetase (TrpRS) characterization

Chapter 27. Tryptophanyl-tRNA synthetase (TrpRS) in phosphosignaling

Chapter 28. Tryptophanyl-tRNA synthetase antigenic epitopes and mimotpes

Chapter 29. Interactomes: tryptophanyl-tRNA synthetase forms and other aminoacyl-tRNA synthetases

Chapter 30. Tryptophanyl-tRNA synthetase in cell and organism survival

Chapter 31. Tryptophanyl-tRNA synthetase sharing epitopes

Chapter 32. Tryptamine and Tryptophanyl-tRNA synthetase in microvesicles, multivesicular bodies, and exosomes

Chapter 33. Tryptophanyl-tRNA synthetase and tryptamine in protein kinase and cancer pathways

Chapter 34. Global protein biosynthesis and aminoacyl-tRNA synthetase family


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© Academic Press 2021
2nd November 2020
Academic Press
Paperback ISBN:

About the Author

Elena Paley

Dr. Elena Paley is the Founder, President & CEO of Expert Biomed Inc., and Co-founder and Director of Stop Alzheimer’s Corp. She completed her PhD in Biology at The Engelhardt Institute of Molecular Biology, at the Russian Academy of Sciences, Moscow, Russia and later conducted postdoctoral research at the University of Miami School of Medicine, Miami, FL. Dr. Paley's research focuses on protein biosynthesis interference in disease, with emphasis on cancer and neurodegenerative disease. During her career she has taught and held professorships at Northwestern University Feinberg School of Medicine and Nova Southeastern University in Ft. Lauderdale, FL, among other schools. Dr. Paley is on the review board of various scientific journals, including the Journal of Alzheimer’s Disease and Current Alzheimer Research.

Affiliations and Expertise

Founder, President & CEO Expert Biomed Inc., FL, USA Co-founder and Director Stop Alzheimer’s Corp., FL, USA Adjunct Professor, Nova Southeastern University, FL, U.S.A. The Engelhardt Institute of Molecular Biology, at the Russian Academy of Sciences, Moscow, Russia

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