Protein Biosynthesis Interference in Disease

Protein Biosynthesis Interference in Disease

1st Edition - October 8, 2020

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  • Author: Elena Paley
  • eBook ISBN: 9780128234860
  • Paperback ISBN: 9780128234853

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Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer’s and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand the underlying factors of protein disease and improve patient outcomes.

Key Features

  • Enables biochemists, molecular biologists and disease researchers to advance disease prevention, laboratory testing, and treatment pathways for protein biosynthesis interference related disorders
  • Examines the biochemical and molecular basis of protein biosynthesis interference in neurodegenerative disorders, cancer and inflammatory conditions, among other diseases
  • Analyzes tryptamine, biogenic amines, and aminoacyl-tRNA synthetases dynamics in protein translation and possible treatment pathways regulating protein biosynthesis


Active researchers and students of biochemistry, molecular biology, cellular biology, neuroscience, protein biochemistry, and nutrition. Clinicians and students of life science and medicine

Table of Contents

  • 1. Introduction
    2. Tryptamine in the diet, human microbiome, tRNA aminoacylation-protein biosynthesis, host-microbiota metabolic interactions
    3. Dimethyltryptamine, methyltryptamine, hallucinations and metals
    4. Psychoactive effects and toxicity of tryptamine, N-methyltryptamine (NMT) and N, N-dimethyltryptamine (DMT): quantification methods
    5. Tryptamine in renal pathologies and in pregnancy
    6. Tryptophanyl-tRNA synthetase (TrpRS) inhibition or TrpRS gene (WARS) mutations and deletion result to TrpRS deficiency and pathologies
    7. Tryptamine in liver diseases and alcohol abuse
    8. Tryptamine and tyramine in tobacco smoking
    9. Tryptamine and other biogenic amines in human vaginal samples
    10. Tryptamine and tryptophan in human fecal samples: diet alters tryptamine levels
    11. Tryptamine in human noncataractous and cataractous eye lenses
    12. Tryptamine toxicity in rats, adrenalectomy, toxicity prevention
    13. Microorganisms: the natural producers of tryptamine in food
    14. Human gut bacterial sequence associated with Alzheimer’s disease and biogenic amines
    15. Disease, factors and condition associated with Alzheimer’s disease (AD) and dementia support a concept that AD is a widespread systemic disorder
    16. Arterial hypertension in comorbidity in dementia and Alzheimer’s disease, tryptamine in metabolic syndrome
    17. Whole blood viscosity: biogenic amines, dementia and Alzheimer’s disease
    18. Tryptamine and aminoacyl-tRNAs in sleep-wake and circadian disruptions
    19. Senile plaques and/or neurofibrillary tangles in brain of non-demented individuals
    20. Historical perspectives and future research directions
    21. Tryptamine content and effects in humans and animals
    22. Link protein half-lives to neurodegeneration: tryptamine treatment effects
    23. Alzheimer’s disease human gut microbiome associated sequence (ADAS): predictive disease modeling with ADAS: generating ADAS variants from human samples
    24. Tryptamine and other biogenic amines (BA) as modified and degradable factors
    25. Tryptamine and TrpRS in cancer and other conditions
    26. Experimental procedures: tryptophanyl-tRNA synthetase (TrpRS) characterization
    27. Tryptophanyl-tRNA synthetase (TrpRS) in phosphosignaling
    28. Tryptophanyl-tRNA synthetase antigenic epitopes and mimotpes
    29. Interactomes: tryptophanyl-tRNA synthetase forms and other aminoacyl-tRNA synthetases
    30. Tryptophanyl-tRNA synthetase in cell and organism survival
    31. Tryptophanyl-tRNA synthetase sharing epitopes
    32. Tryptamine and Tryptophanyl-tRNA synthetase in microvesicles, multivesicular bodies, and exosomes
    33. Tryptophanyl-tRNA synthetase and tryptamine in protein kinase and cancer pathways
    34. Global protein biosynthesis and aminoacyl-tRNA synthetase family

Product details

  • No. of pages: 296
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: October 8, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128234860
  • Paperback ISBN: 9780128234853

About the Author

Elena Paley

Dr. Elena Paley is the Founder, President & CEO of Expert Biomed Inc., and Co-founder and Director of Stop Alzheimer’s Corp. She completed her PhD in Biology at The Engelhardt Institute of Molecular Biology, at the Russian Academy of Sciences, Moscow, Russia and later conducted postdoctoral research at the University of Miami School of Medicine, Miami, FL. Dr. Paley's research focuses on protein biosynthesis interference in disease, with emphasis on cancer and neurodegenerative disease. During her career she has taught and held professorships at Northwestern University Feinberg School of Medicine and Nova Southeastern University in Ft. Lauderdale, FL, among other schools. Dr. Paley is on the review board of various scientific journals, including the Journal of Alzheimer’s Disease and Current Alzheimer Research.

Affiliations and Expertise

Founder, President and CEO Expert Biomed Inc.; Co-founder and Director Stop Alzheimer’s Corp.; Adjunct Professor, Nova Southeastern University, FL, USA; The Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia

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  • Subbarayan P. Thu Oct 28 2021

    Protein Biosynthesis Interference in Disease

    It is a timely collection of articles by eminent researchers. The editor is an authority in protein biosynthesis and metabolism.