Secure CheckoutPersonal information is secured with SSL technology.
Free ShippingFree global shipping
No minimum order.
Protein Biosynthesis Interference in Disease offers a thorough discussion and overview of protein biosynthesis interference, its mechanisms of action, and influence over disease processes. This book examines the role of protein biosynthesis interference in Alzheimer’s and other neurodegenerative conditions, cancer and inflammatory disorders, with specific attention paid to the biochemical dynamics of tryptamine, biogenic amines and aminoacyl-tRNA synthetases in these pathologies. Methods of regulating protein translation and interference mechanisms, including gene therapy, are presented, empowering biochemists, molecular biologists, disease researchers, and health professionals to understand the underlying factors of protein disease and improve patient outcomes.
- Enables biochemists, molecular biologists and disease researchers to advance disease prevention, laboratory testing, and treatment pathways for protein biosynthesis interference related disorders
- Examines the biochemical and molecular basis of protein biosynthesis interference in neurodegenerative disorders, cancer and inflammatory conditions, among other diseases
- Analyzes tryptamine, biogenic amines, and aminoacyl-tRNA synthetases dynamics in protein translation and possible treatment pathways regulating protein biosynthesis
Active researchers and students of biochemistry, molecular biology, cellular biology, neuroscience, protein biochemistry, and nutrition. Clinicians and students of life science and medicine
Chapter 1. Introduction
Chapter 2. Tryptamine in the diet, human microbiome, tRNA aminoacylation-protein biosynthesis, host-microbiota metabolic interactions
Chapter 3. Dimethyltryptamine, methyltryptamine, hallucinations and metals
Chapter 4. Psychoactive effects and toxicity of tryptamine, N-methyltryptamine (NMT) and N, N-dimethyltryptamine (DMT): quantification methods
Chapter 5. Tryptamine in renal pathologies and in pregnancy
Chapter 6. Tryptophanyl-tRNA synthetase (TrpRS) inhibition or TrpRS gene (WARS) mutations and deletion result to TrpRS deficiency and pathologies
Chapter 7. Tryptamine in liver diseases and alcohol abuse
Chapter 8. Tryptamine and tyramine in tobacco smoking
Chapter 9. Tryptamine and other biogenic amines in human vaginal samples
Chapter 10. Tryptamine and tryptophan in human fecal samples: diet alters tryptamine levels
Chapter 11. Tryptamine in human noncataractous and cataractous eye lenses
Chapter 12. Tryptamine toxicity in rats, adrenalectomy, toxicity prevention
Chapter 13. Microorganisms: the natural producers of tryptamine in food
Chapter 14. Human gut bacterial sequence associated with Alzheimer’s disease and biogenic amines
Chapter 15. Disease, factors and condition associated with Alzheimer’s disease (AD) and dementia support a concept that AD is a widespread systemic disorder
Chapter 16. Arterial hypertension in comorbidity in dementia and Alzheimer’s disease, tryptamine in metabolic syndrome
Chapter 17. Whole blood viscosity: biogenic amines, dementia and Alzheimer’s disease
Chapter 18. Tryptamine and aminoacyl-tRNAs in sleep-wake and circadian disruptions
Chapter 19. Senile plaques and/or neurofibrillary tangles in brain of non-demented individuals
Chapter 20. Historical perspectives and future research directions
Chapter 21. Tryptamine content and effects in humans and animals
Chapter 22. Link protein half-lives to neurodegeneration: tryptamine treatment effects
Chapter 23. Alzheimer’s disease human gut microbiome associated sequence (ADAS): predictive disease modeling with ADAS: generating ADAS variants from human samples
Chapter 24. Tryptamine and other biogenic amines (BA) as modified and degradable factors
Chapter 25. Tryptamine and TrpRS in cancer and other conditions
Chapter 26. Experimental procedures: tryptophanyl-tRNA synthetase (TrpRS) characterization
Chapter 27. Tryptophanyl-tRNA synthetase (TrpRS) in phosphosignaling
Chapter 28. Tryptophanyl-tRNA synthetase antigenic epitopes and mimotpes
Chapter 29. Interactomes: tryptophanyl-tRNA synthetase forms and other aminoacyl-tRNA synthetases
Chapter 30. Tryptophanyl-tRNA synthetase in cell and organism survival
Chapter 31. Tryptophanyl-tRNA synthetase sharing epitopes
Chapter 32. Tryptamine and Tryptophanyl-tRNA synthetase in microvesicles, multivesicular bodies, and exosomes
Chapter 33. Tryptophanyl-tRNA synthetase and tryptamine in protein kinase and cancer pathways
Chapter 34. Global protein biosynthesis and aminoacyl-tRNA synthetase family
- No. of pages:
- © Academic Press 2021
- 2nd November 2020
- Academic Press
- Paperback ISBN:
Dr. Elena Paley is the Founder, President & CEO of Expert Biomed Inc., and Co-founder and Director of Stop Alzheimer’s Corp. She completed her PhD in Biology at The Engelhardt Institute of Molecular Biology, at the Russian Academy of Sciences, Moscow, Russia and later conducted postdoctoral research at the University of Miami School of Medicine, Miami, FL. Dr. Paley's research focuses on protein biosynthesis interference in disease, with emphasis on cancer and neurodegenerative disease. During her career she has taught and held professorships at Northwestern University Feinberg School of Medicine and Nova Southeastern University in Ft. Lauderdale, FL, among other schools. Dr. Paley is on the review board of various scientific journals, including the Journal of Alzheimer’s Disease and Current Alzheimer Research.
Founder, President & CEO Expert Biomed Inc., FL, USA Co-founder and Director Stop Alzheimer’s Corp., FL, USA Adjunct Professor, Nova Southeastern University, FL, U.S.A. The Engelhardt Institute of Molecular Biology, at the Russian Academy of Sciences, Moscow, Russia
Elsevier.com visitor survey
We are always looking for ways to improve customer experience on Elsevier.com.
We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit.
If you decide to participate, a new browser tab will open so you can complete the survey after you have completed your visit to this website.
Thanks in advance for your time.