Protein-Based Biopolymers

From Source to Biomedical Applications

1st Edition - September 29, 2022
Editors: Susheel Kalia, Swati Sharma
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 5 4 5 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 6 5 5 - 5

Protein-Based Biopolymers: From Source to Biomedical Applications provides an overview on the development and application of protein biopolymers in biomedicine. Protein polymers… Read more

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Protein-Based Biopolymers: From Source to Biomedical Applications provides an overview on the development and application of protein biopolymers in biomedicine. Protein polymers have garnered increasing focus in the development of biomedical materials, devices and therapeutics due to their intrinsic bioactivity, biocompatibility and biodegradability. This book comprehensively reviews the latest advances on the synthesis, characterization, properties and applications of protein-based biopolymers. Each chapter is dedicated to a single protein class, covering a broad range of proteins including silk, collagen, keratin, fibrin, and more. In addition, the book explores the biomedical potential of these polymers, from tissue engineering, to drug delivery and wound healing.

This book offers a valuable resource for academics and researchers in the fields of materials science, biomedical engineering and R&D groups working in pharmaceutical and biomedical industries.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. An introduction to protein-based biopolymers
Abstract
1.1 Introduction
1.2 Protein and its biopolymers
1.3 Applications
1.4 Protein-based biopolymers nanoparticles
1.5 Challenges and future prospects
Acknowledgments
References
Chapter 2. Fabrication, properties and applications of gluten protein
Abstract
2.1 Introduction
2.2 Methods of protein fabrication
2.3 Properties of wheat gluten
2.4 Applications of gluten protein
2.5 Conclusion
References
Chapter 3. Keratin for potential biomedical applications
Abstract
3.1 Introduction
3.2 Keratin in the history
3.3 Structure and the characteristic features of keratin
3.4 Keratin-based biomaterials and their biomedical applications
3.5 Conclusion
References
Chapter 4. Fabrication, properties, and biomedical applications of soy protein-based materials
Abstract
4.1 Introduction
4.2 Soy protein properties
4.3 Fabrication of soy protein-based biomaterials
4.4 Biomedical applications
4.5 Challenges and future prospects
References
Chapter 5. Sodium caseinate versus sodium carboxymethyl cellulose as novel drug delivery carriers
Abstract
5.1 Introduction
5.2 Synthesis and characterization of biopolymer composites as hydrogels for controlling the release of drug
5.3 Effective role of protein-based composite hydrogel versus cellulose-based composite hydrogel
5.4 Conclusions
Acknowledgments
References
Chapter 6. Silk-based biomaterials for biomedical applications
Abstract
6.1 Introduction
6.2 Components of silk
6.3 Development of silk-based biomaterials
6.4 Biomedical applications
6.5 Future prospective
6.6 Conclusions
Acknowledgments
References
Chapter 7. Protein-based nanoparticles as drug delivery nanocarriers
Abstract
7.1 Introduction
7.2 Pr-NPs and drug delivery
7.3 Emerging research on Pr-NPs assisted drug delivery
7.4 Future approach for Pr-NPs assisted drug delivery
7.5 Conclusions
Acknowledgments
References
Chapter 8. Peptide and protein-based hydrogels for the encapsulation of bioactive compounds and tissue engineering applications
Abstract
8.1 Introduction
8.2 Characteristics of gels
8.3 Gel formulation methods
8.4 Classification and types of gels
8.5 Hydrogels
8.6 Protein-based hydrogels
8.7 Peptide-based hydrogels
8.8 Synthesis of peptide-based hydrogels
8.9 Bioactive compounds
8.10 Encapsulation
8.11 Peptide hydrogels for encapsulating bioactive compounds
8.12 Tissue engineering
8.13 Keratin
8.14 Keratin-based hydrogel for wound healing
8.15 Regeneration of bone tissue engineering using Nap-FFY based hydrogels
8.16 Formation of a desired organ/tissue
8.17 Albumin based hydrogels for skin regeneration and wound healing
8.18 Blood vessels formation in damaged tissues with mussel adhesive protein
8.19 Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration
8.20 Cartilage tissue engineering using silk-based hydrogels
8.21 Conclusion
Acknowledgments
References
Chapter 9. Silver nanoparticles and protein polymer-based nanomedicines
Abstract
9.1 Introduction
9.2 Protein-based Ag nanoparticles
9.3 Collagen-based silver nanoparticles
9.4 Keratin-silver nanoparticles
9.5 Soy protein-silver nanoparticles-based materials
9.6 Controlling agents for particle formation
9.7 Toxicity of protein-stabilized Ag nanoparticles
9.8 Protein polymer-based nanomedicines
9.9 Conclusions
Authors’ contributions
Conflicts of interest
References
Chapter 10. Antimicrobial potential of protein-based bioplastics
Abstract
10.1 Introduction
10.2 Bioplastics production
10.3 Methods to enhance bioplastic functions
10.4 Evaluation of the properties of antimicrobial protein-based bioplastics
10.5 Current status and future perspectives
Acknowledgments
References
Chapter 11. Reinforced protein polymers in biomedical engineering
Abstract
11.1 Introduction
11.2 Polymerization
11.3 Polymers and biopolymers
11.4 Physiochemical properties of proteins
11.5 Biopolymers
11.6 Reinforcement of a protein
11.7 Chemical and physical treatment
11.8 Applications of reinforced protein in tissue engineering
Acknowledgments
References
Chapter 12. Enzymes: classification and biomedical applications
Abstract
12.1 Introduction
12.2 Classification of enzymes
12.3 Role of enzymes in biosensors
12.4 Isolation and modification of enzymes
12.5 Conclusions
References
Index

Susheel Kalia

Susheel Kalia is Associate Professor and Head of the Department of Chemistry, at the Army Cadet College Wing of the Indian Military Academy in Dehradun, India. He was a Postdoc Researcher in 2013 and a Visiting Professor at the University of Bologna, Italy in 2020. Kalia has published over 85 research articles in international journals, as well as co-editing 20 books, authored 11 book chapters, and received more than 8,000 citations over his academic career. His research interests include polymeric bio- and nanocomposites, surface modification, conducting polymers, nanofibers, nanoparticles, nano ferrites, hybrid materials, and hydrogels. Dr. Kalia is Series Editor of a book series on polymer and composite materials, and an editorial board member of the International Journal of Plastics Technology. In addition, he is a member of several professional organizations, including the Asian Polymer Association, Indian Cryogenics Council, the Society for Polymer Science, the Indian Society of Analytical Scientists, and the International Association of Advanced Materials.

Affiliations and expertise

Associate Professor and Head, Department of Chemistry, Army Cadet College Wing of Indian Military Academy Dehradun, India

Swati Sharma

Dr. Swati Sharma (MSc, Dr. Yashwant Singh Parmar University of Horticulture and Forestry, Nauni Solan H.P. India; PhD. University Malaysia, Pahang, Malaysia) is Assistant Professor at University Institute of Biotechnology, the Chandigarh University Mohali, India. She worked as a visiting researcher in the College of Life and Environmental Sciences at Konkuk University, Seoul, South Korea. She has also worked as a program co-coordinator at the Himalayan Action Research Center (HARC), Dehradun, and Senior Research Fellow at the India Agricultural Research Institute in 2013-2014. Presently, Dr. Sharma's research is in the field of bioplastics, hydrogels, keratin nano-fibers and nano-particles, biodegradable polymers and polymers with antioxidant and anticancer activities and sponges. Dr. Swati has published numerous books and papers in various internationally reputed journals.

Affiliations and expertise

Assistant Professor, Chandigarh University