Proteases in Health and Disease

Proteases in Health and Disease

1st Edition - January 24, 2011

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  • Editor: Enrico Di Cera
  • eBook ISBN: 9780123855053
  • Hardcover ISBN: 9780123855046

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Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments.

Key Features

  • Discusses new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine

Table of Contents

  • 1. Membrane-Anchored Serine Proteases in Health and Disease
    Toni M. Antalis, Thomas Bugge, and Qingyu Wu
    2. Complex Assemblies of Factor IX and X Regulate the Initiation, Maintenance, and Shutdown of Blood Coagulation
    Thomas Zögg and Hans Brandstetter
    3. Structure and Proteolytic Properties of ADAMTS13, a Metalloprotease Involved in the Pathogenesis of Thrombotic Microangiopathies
    Stefano Lancellotti and Raimondo De Cristofaro
    4. Thrombin as an Anticoagulant
    Enrico Di Cera
    5. Regulation of Proteases by Protein Inhibitors of the Serpin Superfamily
    Steven T. Olson and Peter G.W. Gettins
    6. Multiple Roles of Metalloproteinases in Neurological Disorders
    Yi Yang, Jeff W. Hill, and Gary A. Rosenberg

Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: January 24, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123855053
  • Hardcover ISBN: 9780123855046

About the Editor

Enrico Di Cera

Affiliations and Expertise

Washington University School of Medicine, St. Louis, Missouri, U.S.A.

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