Proceedings of the 7Th International Congress of Pharmacology, Paris 1978

1st Edition - January 1, 1979

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  • Editor: B. B. Vargaftig
  • eBook ISBN: 9781483156354

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Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immunopharmacology contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Table of Contents

  • Introduction

    Prostaglandins, Thromboxanes and Prostacyclin


    Prostaglandin Endoperoxides and Thromboxanes: Biochemistry and Biological Role

    Unstable Metabolites of Arachidonic Acid in Relation to Thrombosis

    The Role of Biologically Active Lipids in Platelet Aggregation

    Synthesis of Prostaglandins by Vascular and Nonvascular Renal Tissues and the Presence of an Endogenous Prostaglandin Synthesis Inhibitor in the Cortex

    Endogenous and Exogenous Metabolites of Arachidonic Acids and Cyclic

    Nucleotides in the Central Nervous System

    Pharmacological Interference in Biotransformation of Arachidonic Acid

    Participation of Prostaglandins in Inflammatory Pain

    Pharmacology Of Platelets

    Introductory Remarks

    Factors Affecting the Formation and Actions of Cyclic AMP in Blood Platelets

    The Role of Calcium Ions in the Regulation of Platelet Function and their Pharmacological Control

    Platelet Secretion (Release Reaction): Mechanism and Pharmacology

    Prostaglandin Endoperoxides and Thromboxanes: Role in Platelets

    Influence of Antiadrenergic Drugs on Platelet Function

    Abnormal Platelets as Models for Understanding the Mechanisms of Platelet Function

    Pharmacological Approaches to Enhancement of Immunity

    Mediators of Cellular Immunity

    A New Approach to Immunostimulâtion: Thymic Factors

    Pharmacological Enhancement of Immunity: Role of Thymosin and the Endocrine Thymus in the Maintenance of Immune Balance

    Effects of Thymosin Fraction 5 in Cancer Patients: In Vitro Studies and Correlations with Clinical Course in Patients Receiving Thymosin

    Studies of Levamisole in Experimental Tumor Systems

    Studies on the Immunoregulatory Activities of Non-Toxic Synthetic Polyribonucleotides

    Immunopharmacological Activities of Muramyl Dipeptide, a Synthetic Mycobacterial Analog

    Invited Lecture

    Immune Receptors and Cell Differentiation


Product details

  • No. of pages: 236
  • Language: English
  • Copyright: © Pergamon 1979
  • Published: January 1, 1979
  • Imprint: Pergamon
  • eBook ISBN: 9781483156354

About the Editor

B. B. Vargaftig

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