Advances in Pharmacology and Therapeutics, Volume 4: Prostaglandins-Immunopharmacology contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of prostaglandins, their immunopharmacology, and their therapeutic applications. Topics covered range from the biochemistry of prostaglandins, thromboxanes, and prostacyclin to the pharmacology of blood platelets and pharmacological approaches to enhancement of immunity. This volume is comprised of 23 chapters and opens with a discussion on the discovery of prostaglandins and their possible biological functions, including platelet aggregation and adrenergic neurotransmission. The reader is then introduced to unstable metabolites of arachidonic acid in relation to thrombosis; pharmacological interference in biotransformation of arachidonic acid; participation of prostaglandins in inflammatory pain; and factors affecting the formation and actions of cyclic AMP in blood platelets. The following chapters explore the role of thymosin and the endocrine thymus in the maintenance of immune balance; effects of thymosin fraction 5 in cancer patients; and the immunoregulatory activities of non-toxic synthetic polyribonucleotides. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.
Introduction Prostaglandins, Thromboxanes and Prostacyclin Prostaglandins Prostaglandin Endoperoxides and Thromboxanes: Biochemistry and Biological Role Unstable Metabolites of Arachidonic Acid in Relation to Thrombosis The Role of Biologically Active Lipids in Platelet Aggregation Synthesis of Prostaglandins by Vascular and Nonvascular Renal Tissues and the Presence of an Endogenous Prostaglandin Synthesis Inhibitor in the Cortex Endogenous and Exogenous Metabolites of Arachidonic Acids and Cyclic Nucleotides in the Central Nervous System Pharmacological Interference in Biotransformation of Arachidonic Acid Participation of Prostaglandins in Inflammatory Pain Pharmacology Of Platelets Introductory Remarks Factors Affecting the Formation and Actions of Cyclic AMP in Blood Platelets The Role of Calcium Ions in the Regulation of Platelet Function and their Pharmacological Control Platelet Secretion (Release Reaction): Mechanism and Pharmacology Prostaglandin Endoperoxides and Thromboxanes: Role in Platelets Influence of Antiadrenergic Drugs on Platelet Function Abnormal Platelets as Models for Understanding the Mechanisms of Platelet Function Pharmacological Approaches to Enhancement of Immunity Mediators of Cellular Immunity A New Approach to Immunostimulâtion: Thymic Factors Pharmacological Enhancement of Immunity: Role of Thymosin and the Endocrine Thymus in the Maintenance of Immune Balance Effects of Thymosin Fraction 5 in Cancer Patients: In Vitro Studies and Correlations with Clinical Course in Patients Receiving Thymosin Studies of Levamisole in Experimental Tumor Systems Studies on the Immunoregulatory Activities of Non-Toxic Synthetic Polyribonucleotides Immunopharmacological Activities of Muramyl Dipeptide, a Synthetic Mycobacterial Analog Invited Lecture Immune Receptors and Cell Differentiation Index
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- © Pergamon 1979
- 1st January 1979
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