Prostaglandins and Thromboxanes

Prostaglandins and Thromboxanes

Butterworths Monographs in Chemistry

1st Edition - April 22, 1982

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  • Editors: Roger F. Newton, Stanley M. Roberts
  • eBook ISBN: 9781483161099

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Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discuss the two lipids' basic and advanced synthesis, pharmacology, biosynthesis, biological activity, chemical interconversions, and metabolism, along with its subtopics. The book will serve as an excellent reference for undergraduate and graduate students in the related field.

Table of Contents

  • Preface

    1. History, Nomenclature and Potential Uses of Prostaglandins and Thromboxanes in the Clinic


    Structures and Nomenclature of Prostaglandins


    Biosynthesis and Metabolism

    Potential Clinical Uses

    2. Biosynthesis and Metabolism of Prostaglandins and Thromboxanes


    Prostaglandin Biosynthesis

    Prostaglandin Metabolism

    3. Pharmacology of Natural Prostaglandins and Analogues


    Mechanism of Action of Prostaglandins and Thromboxanes

    Therapeutic Applications of Prostaglandins

    Further Reading

    4. Synthesis of Prostaglandins from Poly Cyclic Molecules


    Harvard Synthesis

    Glaxo Synthesis

    5. Synthesis of Prostaglandins Involving Conjugate Addition to Cyclopentenones


    Conjugate Addition to 2,4-Disubstituted Cyclopentenones

    Prostaglandin Synthesis by Conjugate Addition and Enolate Trapping

    6. Chemical Interconversions of Prostaglandins: Synthesis of Prostaglandins G2, H2 and I2


    Chemical Interconversions of Prostaglandins D, E and F

    Chemical Interconversions of Prostaglandins A, B, C and E

    Reduction of Prostaglandins of the 2-Series to Prostaglandins of the 1-Series

    Synthesis of Prostaglandins G2 and H2

    Synthesis of Prostaglandin I2

    7. Synthesis of Thromboxanes


    Synthesis of TXB2 from Prostaglandins and Prostaglandin Precursors

    Synthesis from Carbohydrates

    8. Synthesis and Biological Activity of Prostaglandin Analogues Bearing Modified Side Chains


    Alkyl Substituted Analogues

    Dehydro Analogues

    Aryloxy Substituted Analogues

    Heteroatom Substituted Analogues

    C-1 Modified Analogues

    Hybrid Analogues

    9. Synthesis and Biological Activity of Prostaglandin Analogues with Modified Ring Systems


    Incorporation of Additional Ring Substituents


    Additional Fused Rings

    Replacement of the Cyclopentane Ring

    Prostaglandin Endoperoxide Analogues

    Prostaglandin I2 Analogues

    10. Synthesis and Biological Activity of Thromboxane A2 (TXA2) Analogues


    TXA2 Ether Analogues

    Carbocyclic TXA2 Analogues


Product details

  • No. of pages: 156
  • Language: English
  • Copyright: © Butterworth-Heinemann 1982
  • Published: April 22, 1982
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483161099

About the Editors

Roger F. Newton

Stanley M. Roberts

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