Prostaglandin synthesis - 1st Edition - ISBN: 9780120994601, 9780323146784

Prostaglandin synthesis

1st Edition

Authors: Jasjit Bindra
eBook ISBN: 9780323146784
Imprint: Academic Press
Published Date: 1st January 1977
Page Count: 536
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Prostaglandin Synthesis reviews the developments in the preparation and isolation of prostaglandins by synthesis, with emphasis on the more promising and significant approaches. It includes a nomenclature of prostaglandins and considers prostaglandin analogs as well as their structure-activity relationships, prostaglandin interconversions, isomeric prostaglandins, and deoxyprostaglandins. Organized into 21 chapters, this book begins with an overview of prostaglandin biosynthesis and the potential clinical utility of prostaglandins. It then discusses the discovery of prostaglandins and the isolation of prostaglandins E and F, format for structural presentation of prostaglandins, closure of the cyclopentane ring from acyclic precursors, and conjugate addition of organometallic derivatives to alpha-substituted cyclopentenones. It explains the cyclohexane and bicyclohexane precursors, Corey's synthesis of bicyclohexane precursors, bicyclooctane and bicyclononane precursors, and approaches to synthesis of A, B, C, and D prostaglandins. This book is a valuable resource for biochemists and others working in the field of prostaglandin biosynthesis.

Table of Contents

Preface Acknowledgements Conventions

  1. Introduction
  2. Isolation and Structure
  3. Nomenclature
  4. Prostaglandin Syntheses
  5. Acyclic Precursors
  6. Cyclopentane Precursors
  7. Cyclopentane Precursors — Conjugate Addition Approaches
  8. Cyclohexane Precursors
  9. Bicyclohexane Precursors
  10. Bicycloheptane Precursors — Corey's Synthesis
  11. Bicycloheptane Precursors — Miscellaneous Approaches
  12. Bicyclooctane Precursors
  13. Bicyclononane Precursors
  14. A Prostaglandins
  15. B Prostaglandins
  16. C Prostaglandins
  17. D Prostaglandins
  18. Prostaglandin Interconversions
  19. Isomerie Prostaglandins
  20. Deoxyprostaglandins
  21. Prostaglandin Analogs Appendix: Selected Reviews Index


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© Academic Press 1977
Academic Press
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About the Author

Jasjit Bindra

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