Prostaglandin synthesis

Prostaglandin synthesis

1st Edition - January 1, 1977

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  • Author: Jasjit Bindra
  • eBook ISBN: 9780323146784

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Description

Prostaglandin Synthesis reviews the developments in the preparation and isolation of prostaglandins by synthesis, with emphasis on the more promising and significant approaches. It includes a nomenclature of prostaglandins and considers prostaglandin analogs as well as their structure-activity relationships, prostaglandin interconversions, isomeric prostaglandins, and deoxyprostaglandins. Organized into 21 chapters, this book begins with an overview of prostaglandin biosynthesis and the potential clinical utility of prostaglandins. It then discusses the discovery of prostaglandins and the isolation of prostaglandins E and F, format for structural presentation of prostaglandins, closure of the cyclopentane ring from acyclic precursors, and conjugate addition of organometallic derivatives to alpha-substituted cyclopentenones. It explains the cyclohexane and bicyclohexane precursors, Corey's synthesis of bicyclohexane precursors, bicyclooctane and bicyclononane precursors, and approaches to synthesis of A, B, C, and D prostaglandins. This book is a valuable resource for biochemists and others working in the field of prostaglandin biosynthesis.

Table of Contents


  • Preface

    Acknowledgements

    Conventions

    1. Introduction

    2. Isolation and Structure

    3. Nomenclature

    4. Prostaglandin Syntheses

    5. Acyclic Precursors

    6. Cyclopentane Precursors

    7. Cyclopentane Precursors — Conjugate Addition Approaches

    8. Cyclohexane Precursors

    9. Bicyclohexane Precursors

    10. Bicycloheptane Precursors — Corey's Synthesis

    11. Bicycloheptane Precursors — Miscellaneous Approaches

    12. Bicyclooctane Precursors

    13. Bicyclononane Precursors

    14. A Prostaglandins

    15. B Prostaglandins

    16. C Prostaglandins

    17. D Prostaglandins

    18. Prostaglandin Interconversions

    19. Isomerie Prostaglandins

    20. Deoxyprostaglandins

    21. Prostaglandin Analogs

    Appendix: Selected Reviews

    Index






Product details

  • No. of pages: 536
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 1, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323146784

About the Author

Jasjit Bindra

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