Prostaglandin synthesis - 1st Edition - ISBN: 9780120994601, 9780323146784

Prostaglandin synthesis

1st Edition

Authors: Jasjit Bindra
eBook ISBN: 9780323146784
Imprint: Academic Press
Published Date: 1st January 1977
Page Count: 536
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Description

Prostaglandin Synthesis reviews the developments in the preparation and isolation of prostaglandins by synthesis, with emphasis on the more promising and significant approaches. It includes a nomenclature of prostaglandins and considers prostaglandin analogs as well as their structure-activity relationships, prostaglandin interconversions, isomeric prostaglandins, and deoxyprostaglandins. Organized into 21 chapters, this book begins with an overview of prostaglandin biosynthesis and the potential clinical utility of prostaglandins. It then discusses the discovery of prostaglandins and the isolation of prostaglandins E and F, format for structural presentation of prostaglandins, closure of the cyclopentane ring from acyclic precursors, and conjugate addition of organometallic derivatives to alpha-substituted cyclopentenones. It explains the cyclohexane and bicyclohexane precursors, Corey's synthesis of bicyclohexane precursors, bicyclooctane and bicyclononane precursors, and approaches to synthesis of A, B, C, and D prostaglandins. This book is a valuable resource for biochemists and others working in the field of prostaglandin biosynthesis.

Table of Contents


Preface

Acknowledgements

Conventions

1. Introduction

2. Isolation and Structure

3. Nomenclature

4. Prostaglandin Syntheses

5. Acyclic Precursors

6. Cyclopentane Precursors

7. Cyclopentane Precursors — Conjugate Addition Approaches

8. Cyclohexane Precursors

9. Bicyclohexane Precursors

10. Bicycloheptane Precursors — Corey's Synthesis

11. Bicycloheptane Precursors — Miscellaneous Approaches

12. Bicyclooctane Precursors

13. Bicyclononane Precursors

14. A Prostaglandins

15. B Prostaglandins

16. C Prostaglandins

17. D Prostaglandins

18. Prostaglandin Interconversions

19. Isomerie Prostaglandins

20. Deoxyprostaglandins

21. Prostaglandin Analogs

Appendix: Selected Reviews

Index






Details

No. of pages:
536
Language:
English
Copyright:
© Academic Press 1977
Published:
Imprint:
Academic Press
eBook ISBN:
9780323146784

About the Author

Jasjit Bindra