Prostaglandin Research - 1st Edition - ISBN: 9780121946609, 9780323149518

Prostaglandin Research

1st Edition

Editors: Pierre Crabbe
eBook ISBN: 9780323149518
Imprint: Academic Press
Published Date: 1st January 1977
Page Count: 460
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Prostaglandin Research reviews the status of prostaglandin research, with particular emphasis on chemistry. This book highlights the role of scientific research in society in attempting to find drugs, with potential application to therapy, the chief impetus for prostaglandin research. This volume is organized into seven chapters and begins with an overview of the origin and properties of prostaglandins and then outlines the stage of research in the area of biosynthesis of natural entities, especially endoperoxides and thromboxanes. The reader is then introduced to a rich source of natural prostaglandins, the gorgonian Plexaura homomalla, and the pharmacology of prostaglandins. The physical methods used in prostaglandin research are considered, along with the chemistry of natural and modified prostaglandins. This book is aimed at experts in the field, as well as scientists with a general interest in chemistry and biology.

Table of Contents

List of Contributors Preface 1 Introduction, Origin, and Properties I. History II. Nomenclature, Structure, and Stereochemistry III. Natural Occurrence IV. Biological Properties References 2 Prostaglandin Endoperoxides and Thromboxanes: Short-Lived Bioregulators I. Introduction II. Isolation of Endoperoxides III. Transformation into Prostaglandins IV. Transformation into Thromboxanes V. Role of Endoperoxides and Thromboxanes in Platelet Aggregation VI. Other Biological Effects of Endoperoxides and Thromboxanes VII. Assay Methods for Endoperoxides and Thromboxanes VIII. Conclusions References 3 The Gorgonian Plexaura homomalla (Esper) I. Introduction II. Description III. Development, Growth, and Regrowth IV. External Respiration V. Nutrition VI. Activity of the Polyp VII. Ecology VIII. Geographical and Bathymetric Distribution IX. Prospecting and Harvesting X. Summary References 4 Pharmacology of the Prostaglandins I. Introduction II. Actions of Prostaglandins on the Different Body Systems III. Prostaglandin Receptor Sites IV. Postreceptor Events References 5 Physical Methods in Prostaglandin Research I. Introduction II. The Extraction of Prostaglandins III. Purification Procedures IV. Qualitative and Quantitative Analysis of Prostaglandins References 6 Total Syntheses I. Introduction II. Interconversion Reactions III. The Bicyclic Lactone Route IV. The Bicyclo[3.1.0] hexane Route V. The Cyclopentane Epoxide Route VI. The 1,4-Addition Route VII. The Intramolecular Condensation Route VIII. Miscellaneous Approaches References 7 Syntheses of Modified Prostaglandins I. Introduction II. The Bicyclic Lactone Route III. The Bicyclo[3.1.0] hexane Route IV. The Cyclopentane Epoxide Rou


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© Academic Press 1977
Academic Press
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About the Editor

Pierre Crabbe

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