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Progress in Mosquito Research - 1st Edition - ISBN: 9780128024577, 9780128026304

Progress in Mosquito Research, Volume 51

1st Edition

Serial Volume Editor: Alexander S. Raikhel
Hardcover ISBN: 9780128024577
eBook ISBN: 9780128026304
Imprint: Academic Press
Published Date: 25th August 2016
Page Count: 466
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Table of Contents

  • Preface
  • Chapter One: Progress in Gene Editing Transgenesis Genome Manipulation in Mosquitoes
    • Abstract
    • 1 Progress in Mosquito Gene Editing
    • 2 Progress in TE-Based Mosquito Transformation
    • 3 Progress in Controlling Transgene Expression Using Bipartite Systems
    • 4 Progress in φC31 and Recombinase-Mediated Cassette Exchange Recombination in Mosquitoes
    • 5 Considerations and Outlook
    • Acknowledgements
  • Chapter Two: Sex Determination in Mosquitoes
    • Abstract
    • 1 Introduction
    • 2 Sex Determination in D. melanogaster
    • 3 Sex Determination in Insects: Chromosomal Systems and Master Switches Change, While Endpoint Effectors dsx/fru Remain
    • 4 Sex Chromosomes in Mosquitoes
    • 5 Molecular Mechanisms of Sex Determination in Mosquitoes
    • 6 Control of Mosquito-Borne Infectious Diseases Through Manipulation of Genes in the Sex Determination Pathway
    • 7 Concluding Remarks
    • Acknowledgements
  • Chapter Three: Sexual Selection and the Evolution of Mating Systems in Mosquitoes
    • Abstract
    • 1 Introduction
    • 2 The Relevance of Sexual Selection Research for Mosquito Control Strategies
    • 3 Precopulatory Elements of Sexual Selection
    • 4 Postcopulatory Elements of Sexual Selection
    • 5 Conclusions
    • Acknowledgements
  • Chapter Four: The Role of Juvenile Hormone in Mosquito Development and Reproduction
    • Abstract
    • 1 Introduction
    • 2 Regulation of JH Titres
    • 3 The Role of JH in Mosquito Development
    • 4 The Role of JH in Mosquito Reproduction
    • 5 Mechanism of Action of JH
    • 6 Concluding Notes
    • Acknowledgements
  • Chapter Five: Regulation of Reproductive Processes in Female Mosquitoes
    • Abstract
    • 1 Introduction
    • 2 Early Studies of Endocrine Regulation of Mosquito Reproduction
    • 3 Regulation of Ecdysteroidogenesis in the Ovary
    • 4 Molecular Biology of 20E Action in Female Mosquito Reproduction
    • 5 AA/TOR and Insulin Signalling in Mosquito Vitellogenesis
    • 6 Temporal Coordination of Gene Expression in Mosquito Reproduction
    • 7 Concluding Remarks
    • Acknowledgements
  • Chapter Six: Mosquito Peptide Hormones: Diversity, Production, and Function
    • Abstract
    • 1 Introduction
    • 2 Peptide Hormones and Receptor Discovery in Mosquitoes
    • 3 Sources, Processing, and Release of Peptide Hormones in Mosquitoes
    • 4 Peptide Hormone Functions in Mosquitoes
    • Acknowledgements
  • Chapter Seven: Functions of Small RNAs in Mosquitoes
    • Abstract
    • 1 Introduction
    • 2 The RNAi Pathways and the Biogenesis of sncRNAs
    • 3 Conclusions
    • Acknowledgements
  • Chapter Eight: The Complement System of Malaria Vector Mosquitoes
    • Abstract
    • 1 Introduction
    • 2 TEP1 Function in Microbial Clearance
    • 3 Plasmodium Evasion of Mosquito Complement
    • 4 Complement Fixation on Microbial Surfaces: Spontaneous or PRR Mediated?
    • 5 Mosquito Complement Regulation
    • 6 Effector Mechanisms Mediated by Mosquito Complement
    • 7 Structure–Function Studies of Complement Components
    • 8 Concluding Remarks
  • Chapter Nine: Influences of the Mosquito Microbiota on Vector Competence
    • Abstract
    • 1 Introduction
    • 2 Acquisition and Composition of the Mosquito's Endogenous Microbiota
    • 3 The Mosquito Innate Immune System and Interactions with the Endogenous Microbiota
    • 4 Influence of the Mosquito Microbiota on Vector Competence: Plasmodium
    • 5 Influence of the Mosquito Microbiota on Vector Competence: Viruses
    • 6 Entomopathogenic Bacteria and Fungi: Lifespan Attenuation and Vector Competence
    • 7 Microbiota-Based Disease Control Strategies
    • 8 Conclusion
  • Chapter Ten: Mosquito Sensory Systems
    • Abstract
    • 1 Introduction
    • 2 Preadult Life Stages
    • 3 Adults
    • 4 Mosquito Sensory Systems and Disease Transmission
  • Chapter Eleven: Molecular Physiology of Mosquito Diapause
    • Abstract
    • 1 Introduction
    • 2 Diapause Phenotype
    • 3 Diapause Dynamics
    • 4 Genetic Basis for the Capacity to Diapause
    • 5 Environmental Cues
    • 6 Central Role for the Circadian Clock Genes
    • 7 Hormonal Control Pathways
    • 8 The Missing Pieces
    • Acknowledgements
  • Chapter Twelve: Nitrogen Metabolism in Mosquitoes: New Insights into the Nitrogen Metabolism in Blood-Fed Mosquitoes
    • Abstract
    • 1 Introduction
    • 2 Recent Discoveries in Nitrogen Metabolism of A. aegypti Mosquitoes by Using Integrated Approaches
    • 3 Novel Findings on the Metabolic Regulation of Ammonia Metabolism in Mosquitoes
    • 4 Concluding Notes
    • Acknowledgements
  • Chapter Thirteen: Renal Excretory Processes in Mosquitoes
    • Abstract
    • 1 Introduction
    • 2 Malpighian Tubules
    • 3 The Renal Excretory System as a Target for Mosquito Control
  • Index


Progress in Mosquito Research provides readers with the latest interdisciplinary reviews on the topic. It is an essential reference source for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect chemists, with Volume 51 focusing on recent progress in mosquito research.

Key Features

  • Presents a comprehensive overview of recent progress in mosquito science
  • Written by leaders in their respective areas of mosquito research
  • Ideal resource for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect chemists


Researchers and students interested in mosquito science, tropical diseases, and entomology.


No. of pages:
© Academic Press 2016
25th August 2016
Academic Press
Hardcover ISBN:
eBook ISBN:


"This book provides an excellent overview of the recent advances in mosquito biology.

Overall, this is a well-written and well-organized book, and it represents an excellent resource on mosquito physiology for students and professionals working in mosquito biology as well as mosquito control." --The Quarterly Review of Biology, Vol.92, No. 4

Ratings and Reviews

About the Serial Volume Editor

Alexander S. Raikhel

Alexander S. Raikhel is a distinguished professor at the University of California Riverside. He is a graduate of St. Petersburg (formerly Leningrad) State University and the Zoological Institute of the Russian Academy of Sciences, where he worked on ticks in the laboratory of the renowned acarologist professor Yu. S. Balashov. Following immigration to the United States, Raikhel began studies on mosquito reproduction. Throughout the years, his research has focused on regulatory pathways controlling various aspects of mosquito reproductive biology and has contributed significantly to the understanding of vitellogenesis in mosquitoes at cell biological, biochemical and molecular levels. He and his laboratory personnel have investigated juvenile hormone and ecdysone signaling in mosquitoes, and have uncovered the role of nutritional signaling—the amino acid-TOR (Target of Rapamycin) pathway—in mosquito adaptations for obligatory blood feeding. Work from Raikhel's laboratory has added to the knowledge of mosquito metabolism.

Raikhel was among the first to establish genetic transformation in the mosquito Aedes aegypti. He and his co-workers instituted the Aedes aegypti mosquito binary Gal4-UAS system that enables researchers to study cell/tissue-, stage- and sex-specific expression of mosquito genes. These studies have opened the door for the refinement of genetics tools to investigate mosquito-vector interactions. Exploration of immunity in Raikhel’s laboratory was initiated by creating transgenic mosquitoes with altered elements of innate immunity. This provided insight into the Toll and IMD pathways as well as melanization in the mosquito Aedes aegypti. Small non-coding RNAs, microRNAs, are known to control developmental timing, stem cell maintenance and other developmental processes in animals in plants. Work from the Raikhel laboratory has identified microRNAs that play significant roles regulating vital functions of mosquitoes, such as blood digestion and egg maturation.

Raikhel's accomplishments in science have earned him honors, including the 2001 Entomological Society of America Award in Insect Physiology, Biochemistry, and Toxicology and a 2002 National Institutes of Health MERIT Award. In 2009, he was elected a Fellow of the Entomological Society of America and to the National Academy of Sciences.

Affiliations and Expertise

Department of Entomology and Institute for Integrative Genome Biology, University of California Riverside, Riverside, CA, USA