Progress in Medicinal Chemistry, Volume 42
1st Edition
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Description
This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.
Details
- Language:
- English
- Copyright:
- © Elsevier 2004
- Published:
- 15th April 2004
- Imprint:
- Elsevier
- Hardcover ISBN:
- 9780444511430
- eBook ISBN:
- 9780080515199
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