Progress in Medicinal Chemistry - 1st Edition - ISBN: 9780444511430, 9780080515199

Progress in Medicinal Chemistry, Volume 42

1st Edition

eBook ISBN: 9780080515199
Hardcover ISBN: 9780444511430
Imprint: Elsevier
Published Date: 15th April 2004
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Description

This volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.


Details

Language:
English
Copyright:
© Elsevier 2004
Published:
Imprint:
Elsevier
eBook ISBN:
9780080515199
Hardcover ISBN:
9780444511430