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Designing Drugs to Avoid Toxicity
The Safety Window
Common Safety Risks and their SAR
Prostaglandin D2 Receptor CRTH2 Antagonists for the Treatment of Inflammatory Diseases
Asthma as an Unmet Medical Need
Biological Rationale for DP and CRTH2 in Driving Asthma pathogenesis
Assays and Tools for Measuring CRTH2 and DP Biological Activities
Ongoing Clinical Trials with CRTH2 Antagonists in Asthma
Summary and Future Prospects
Progress in the Development of Small Molecule Therapeutics Targeting Th17 Cell Function for the Treatment of Immune-Inflammatory Diseases
Th17 Cells, Th17 Cell Cytokines and their Role in The Pathogenesis and Progression of Immune-Inflammatory Diseases
Targeting Th17 CELL Function for the Treatment of Chronic Immune-Inflammatory Diseases: Emerging Small Molecule Therapeutic Approaches
Regulating Th17 Cell Activity Through Other Molecular Targets: Future Potential
Summary and Future Perspective
Therapeutic Applications of Iminosugars: Current Perspectives and Future Opportunities
IMINOSUGARS – CLASSIFICATION, OCCURRENCE AND HISTORICAL CONTEXT
ADVANTAGEOUS PROPERTIES OF IMINOSUGARS
APPROACHES TO THE SYNTHESIS OF IMINOSUGARS
THERAPEUTIC APPLICATIONS OF IMINOSUGARS
OUTLOOK AND FUTURE OPPORTUNITIES
Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.
- Presents the latest research in the field of drug discovery
- Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry
- Available as an online resource via ScienceDirect
Chemists, biologists, doctors, pharmacists and anyone interested in the contemporary controversy about drugs, drug firms, and the community
- No. of pages:
- © Elsevier Science 2011
- 9th February 2011
- Elsevier Science
- eBook ISBN:
- Hardcover ISBN:
Dr Geoff Lawton has extensive experience in new medicine discovery across many therapeutic areas in both large and small companies and is a co-inventor of a marketed drug (Cilazapril). He is a former Director of Chemistry at Roche UK, and Vice-president Chemistry and Preclinical Sciences within Roche Bioscience, Palo Alto, USA. He was for five years the research member of a global therapy area strategy planning team for inflammatory diseases, aligning research with the clinical development and marketing parts of the business.
From 2003 to 2007 he was founding Research Director with Lectus Therapeutics building from start-up a drug discovery organisation; generating the team, facilities and project portfolio targeting the next generation of ion channel modulating medicines.
Since 2001 Geoff has provided scientific and strategic evaluation and advice on drug discovery as an independent consultant for a number small and medium sized biotech companies, CROs, VCs, academic groups and medical research charities.
Geoff serves on the Board of Antabio, a French biotech company developing tomorrow’s antibacterial drugs.
He is a founder of INMedD, a new medicines discovery social enterprise.
St. Ippolyts, Herts, UK
Dr David Witty has more than 20 years experience in the pharmaceutical industry as a medicinal chemist and project leader working principally in areas of anti-infectives, metabolic diseases, cognition and pain, delivering clinical candidates for several conditions. He led IT Strategy within the Neurology division of GSK, developing and deploying the first Electronic Notebooks for drug discovery to sites in the UK and Singapore. He has contributed more than 90 scientific papers, reviews, patents and books on medicinal and synthetic chemistry.
In 2010 David and several colleagues successfully raised $35M in venture funding to found Convergence Pharmaceuticals, a specialist ion channel company focused on the development of novel treatments for pain, based in Cambridge UK. David presently leads their discovery programme and manages scientific operations within the business.
David is chairman of the Fine Chemicals Group of the Society of Chemical Industry, with responsibility for the delivery of conferences, seminars and training courses for chemists throughout the UK and Europe, and advising parliamentary bodies on matters of relevance to the UK chemical industry.
Since 2008 David has been a STEM ambassador for SETPOINT, introducing school students at both primary and secondary level to the excitement and possibilities of pursuing scientific careers, through workshops, lectures and competitions.
WITNET LTD, Cambridge, UK
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