Description

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.

Key Features

*Presents the latest research in the field of drug discovery
*Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect

Readership

Chemists, biologists, doctors, pharmacists and anyone interested in the contemporary controversy about drugs, drug firms, and the community

Table of Contents

Designing Drugs to Avoid Toxicity

Introduction

The Safety Window

Common Safety Risks and their SAR

Conclusions

Prostaglandin D2 Receptor CRTH2 Antagonists for the Treatment of Inflammatory Diseases

Asthma as an Unmet Medical Need

Biological Rationale for DP and CRTH2 in Driving Asthma pathogenesis

Assays and Tools for Measuring CRTH2 and DP Biological Activities

CRTH2 Antagonists

Ongoing Clinical Trials with CRTH2 Antagonists in Asthma

Summary and Future Prospects

Progress in the Development of Small Molecule Therapeutics Targeting Th17 Cell Function for the Treatment of Immune-Inflammatory Diseases

Introduction

Th17 Cells, Th17 Cell Cytokines and their Role in The Pathogenesis and Progression of Immune-Inflammatory Diseases

Targeting Th17 CELL Function for the Treatment of Chronic Immune-Inflammatory Diseases: Emerging Small Molecule Therapeutic Approaches

Regulating Th17 Cell Activity Through Other Molecular Targets: Future Potential

Summary and Future Perspective

Therapeutic Applications of Iminosugars: Current Perspectives and Future Opportunities

INTRODUCTION

IMINOSUGARS – CLASSIFICATION, OCCURRENCE AND HISTORICAL CONTEXT

ADVANTAGEOUS PROPERTIES OF IMINOSUGARS

APPROACHES TO THE SYNTHESIS OF IMINOSUGARS

THERAPEUTIC APPLICATIONS OF IMINOSUGARS

OUTLOOK AND FUTURE OPPORTUNITIES

Details

No. of pages:
208
Language:
English
Copyright:
© 2010
Published:
Imprint:
Elsevier Science
Electronic ISBN:
9780123812919
Print ISBN:
9780123812902