Progress in Medicinal Chemistry - 1st Edition - ISBN: 9780444509598, 9780080515113

Progress in Medicinal Chemistry, Volume 39

1st Edition

Serial Editors: F.D. King A.W. Oxford
eBook ISBN: 9780080515113
Hardcover ISBN: 9780444509598
Imprint: Elsevier Science
Published Date: 24th April 2002
Page Count: 273
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Description

This volume covers contemporary advances in five important areas of pharmacology and medicinal chemistry including: a comprehensive account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis, and other peripheral and central indications; adoc umented survey of semi-synthetic and totally synthetic antibiotics and anti HIV agents and their sites of interaction; inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) developed for the treatment of hypercholesterolemia; and recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action. Inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), required for viral replication, is one of the most attractive targets for HCV infections. Progress and prospects in the design of peptide and non-peptide inhibitors are described here. design and clinical potential of new drug molecules; valuable summaries of structure-activity relationships in topical areas of medicinal chemistry; and extensive references to the biology, medicinal chemistry and clinical aspects of each topic.


Details

No. of pages:
273
Language:
English
Copyright:
© Elsevier Science 2002
Published:
Imprint:
Elsevier Science
eBook ISBN:
9780080515113
Hardcover ISBN:
9780444509598

Reviews

"...a valuable source of reference" --British Medical Journal
"...may the Progress in Medicinal Chemistry series continue its invaluable service..." --Chemistry and Industry


About the Serial Editors

F.D. King Serial Editor

Affiliations and Expertise

SmithKIine Beecham Pharmaceuticals New Frontiers Science Park (North) Third Avenue

A.W. Oxford Serial Editor

Affiliations and Expertise

Consultant in Medicinal Chemistry