Progress in Immunology VI

Contributors

Introduction

Developmental Biology of the Immune System

The Burnetian Legacy: A Clonal Selectionist Looks Toward the 1990s

Ontogeny and Differentiation of B Lymphocytes

B Cell Development in Birds and Mammals

Generation of Diversity During B Cell Ontogeny in the Chicken

Molecular and Cellular Characteristics of Clonable Pre-B Cells

B Lymphocyte Genesis in the Bone Marrow

Ontogeny and Differentiation of T Lymphocytes

Role of Self Antigens in the Selection of the Developing T Cell Repertoire

Thymic Influences on T Cell Development

Role of Self-Reactivity in the Generation of the T Cell Specificity Repertoire

Ontogeny of T Cell Receptors for Antigen

Mature and Immature Thymocytes

Structure and Function of Recognition Structures

Diversification of Immunoglobulins and T Cell Receptors

Immunoglobulins

Three-Dimensional Structure and Specificity of Monoclonal Antilysozyme Antibodies

Mutation and Selection of Antibodies

The Influence of Somatic Mutation on the Immune Response

Fab Assembly: An Analysis of Different CH1 : CL Combinations

The T Cell Receptor Complex

Expression of the Antigen-Specific MHC-Restricted T Cell Receptor

Structural and Genetic Aspects of the T Cell Receptor-T3 Complex

Genes Encoding the α-, β-, and γ-Chains of the Human T Cell Antigen Receptor

Class I and Class II MHC Products

Diversification of H-2 Genes through Recombination: A Study of Kb Mutants

The Regulation of Ia Gene Transcription

Antigen Presentation and Processing

Antigen Presentation: Paradigm Lost?

Interaction between Protein-Derived Immunogenic Peptides and Ia

The Molecular Context of a Determinant Influences Its Dominant Expression in a T Cell Response Hierarchy through "Fine Processing"

Antigen Internalization, Processing, and Recycling by Antigen-Presenting Cells

Immunodominance of Amphipathic Peptides and Their Localization on the Cell Surface for Antigen Presentation to Helper T Cells

The Complement System

Molecular Mechanisms of Cytotoxicity: Comparison of Complement and Killer Lymphocytes

Molecular Mechanisms in the Antibacterial Action of Complement

Cell and Molecular Biology of Human Complement Receptors

Molecular Biology of the Human Complement Class III Products of the MHC: Factor I and Its Cofactors

Molecular Regulation of Complement Gene Expression

Regulation of the Immune Response

Epirestriction and a Specialized Subset of T Helper Cells are Key Factors in the Regulation of T Suppressor Cells

B Cell Subsets and B Cell Activation

Regulation of B Lymphocyte Activation: The Roles of Receptor Cross-Linkage and B Cell Stimulatory Factor-1 (BSF-1)

B Cell Activation as a Consequence of Membrane Immunoglobulin-Mediated Antigen Presentation

Regulation of Human B Cell Differentiation: Molecular Structure and Immunological Functions of Human B Cell Differentiation Factor (BSF-2)

Idiotype-Directed Interactions During B Cell Ontogeny

Characteristics of Ly 1 B Cells

T Cell Subsets and T Cell Activation

Multiple Signals Required in Cytolytic T Cell Responses

Regulation of Activation of Cloned Murine T Cells

The Generation of the Repertoire of T Cell Specificities and Functions: Toward a Consistent Model

LM.19: A Novel Developmentally Regulated, Signal-Transducing Lymphocyte Antigen

Adaptive Construction of the Immune Circuit

Lymphokines and Growth Factors

Lymphokines and Growth Factors: Interleukin-2 as a Prototype Lymphocytotrophic Hormone

Interleukin-1

Interferon-γ: Receptors and Effects on MHC Antigen Expression

Molecular Biology of Interleukin-2 and Its Receptor: The Current Status

Autoimmune Disorders

Autoantibodies and Normal Antibodies

The Use of Human T Cell Clones to Dissect HLA and Disease Associations

Resistance to Experimental Autoimmunity Using T Lymphocyte Vaccines

Molecular Genetics of Murine Lupus

Idiotypes and Autoimmunity

Congenital and Acquired Immunodeficiencies

The Human T Lymphotropic Retroviruses and Human Immune Deficiency

Cell Membrane Abnormalities Leading to Immune Deficiency

Role and Molecular Biology of the Interleukin-2-Interleukin-2 Receptor System in Health and Disease

Immunodeficiency Disease: Pathogenesis and Treatment

Immune-Neuroendocrine Interactions

Immune-Neuroendocrine Network

Noradrenergic Sympathetic Innervation of Spleen and Lymph Nodes in Relation to Specific Cellular Compartments

Transmembrane Signaling Mechanisms in Neuroendocrine Modulation of the Thymus-Dependent Immune System

Bidirectional Pathways Between the Brain and Immune System: A Role for Thymosin Peptides

A Molecular Basis for Bidirectional Communication Between the Immune and Neuroendocrine Systems

Oncogenesis and Tumor Immunity

Oncogene Activation by Chromosomal Translocations in B Cell-Derived Tumors

Neoplastic Transformation of Lymphoid and Myeloid Cells

Pathogenesis of Lymphoid and Myeloid Tumors

Chronic Myelogenous Leukemia as a Model System for Stem Cell Growth Regulation and Hematolymphoid Development

Mechanisms of Lymphoma Induction by Retroviruses

Lessons from Translocations and Transgenic Mice: Constitutive c-myc Expression Predisposes to Neoplasia

Induction, Expression, and Manipulation of Immunity to Tumors

The Role of Major Histocompatibility Complex Class I Antigens in Antitumor Immunity

Monoclonal Antibody Targeting of Cytotoxic Agents for Cancer Therapy

Tumor-Specific Antigens on Experimental Tumors

New Approaches to the Immunotherapy of Cancer Based on the Systemic Administration of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2

Carcinoembryonic Antigen and Its Utility in the Diagnosis of Colonie Adenocarcinoma

Response of the Host to the Environment

Specificity and Immunogenicity

Regulation of the Immune Response to Infectious Agents

The Regulatory Role of Macrophages in Infection with Intracellular Pathogens

The Role of Specific T Cell Subpopulations in Murine Cutaneous Leishmaniasis

Cytotoxic T Cells in Influenza: Their Role and Viral Specificities

Molecular Concepts of Bacterial Pathogenesis

Mimicry by Virus of Host Molecules: Implications for Autoimmune Disease

The Host-Parasite Relationship: Effector and Escape Mechanisms

Cellular and Molecular Aspects of Host-Parasite Relationships

Nonspecific Cytotoxic Factors and Resistance to Malaria

Current Perspectives on Intestinal Responses to Parasitic Infection

Immunity against Schistosomes in Murine Vaccine Models

Development of a Sporozoite Vaccine against Malaria

Mechanisms and Regulation of Immediate Hypersensitivity

T Cell-Derived Factors and Fibroblast-Derived Factors Regulate the Growth and Differentiation of Mast Cells

Growth and Differentiation of Mast Cells and Basophils

T Cell Factors Involved in the Regulation of IgE Synthesis

Biochemical Events Involved in IgE-Dependent Mediator Release

A Cascade of Regulatory Factors Controls IgE Antibody Synthesis in Vivo and in Vitro

Immunopharmacology: Concepts and Agents

Mode of Action of Interleukins

Radioprotection with Interleukin-1 : Comparison with Other Cytokines

Anti-Interleukin-2 Receptor Monoclonal Antibody Treatment Prolongs Allograft Survival

Neuroimmunopharmacological Activities of Muramyl Peptides

Human Lymphocyte Subsets in Health and Disease

T Cell Ontogeny: Acquisition of a Functional Program

Subsets of Human Peripheral Blood Natural Killer Cells

T Cell Subsets and Function

Immunopathogenesis of the Acquired Immunodeficiency Syndrome (AIDS)

A Postscript: The Response of the Host to the Environment

Host-Graft Relationship

Transplantation Immunobiology

Tissue Transplantation

Transplantation: Achievements and Challenges Outstanding

The Role and Mechanism of Action of Dendritic Cells in Transplantation Immunity

Suppressor Cells and Soluble Transplantation Antigens in Tolerance

Natural Suppressor Cell Systems

Active and Passive Antigen Presentation: Its Role in the Induction of Tissue Immunity and Allograft Tolerance

Reproduction and Embryonic Development

Antigen Expression at Human Maternal-Fetal Interfaces

Role of Cell Surface Molecules in Mammalian Development

Ontogeny of the Immune System in Anuran Amphibians

Decidua-Associated Suppressor Cells and Suppressor Factors Regulating Interleukin-2: Their Role in the Survival of the "Fetal Allograft"

Beyond the Immune System: The Immunotrophic Role of T Cells in Organ Generation and Regeneration

Concluding Remarks

Index