Progress in Immunology VI

Progress in Immunology VI

Sixth International Congress of Immunology

1st Edition - January 1, 1986

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  • Editors: B Cinader, Richard G. Miller
  • eBook ISBN: 9781483276106

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Description

Progress in Immunology VI: Sixth International Congress of Immunology contains the proceedings of the Sixth International Congress of Immunology held in 1986. The papers review advances that have been made in the field of immunology and cover topics ranging from ontogeny and differentiation of B and T lymphocytes to diversification of immunoglobulins and T cell receptors. Antigen presentation and processing, the complement system, and regulation of the immune response are also discussed. Comprised of 105 chapters, this book first explores the developmental biology of the immune system by focusing on the origins of selective theories of antibody formation and the clonal selection hypothesis. Clonal selection and the problem of immunologic tolerance are also considered. Subsequent chapters deal with the structure and function of recognition structures; B cell subsets and B cell activation; T cell subsets and T cell activation; lymphokines and growth factors; and autoimmune disorders. The remaining sections are devoted to oncogenesis and tumor immunity; the response of the host to the environment; and host-graft relationship. This monograph will be of interest to immunologists and biologists.

Table of Contents


  • Contributors

    Introduction

    Developmental Biology of the Immune System

    The Burnetian Legacy: A Clonal Selectionist Looks Toward the 1990s

    Ontogeny and Differentiation of B Lymphocytes

    B Cell Development in Birds and Mammals

    Generation of Diversity During B Cell Ontogeny in the Chicken

    Molecular and Cellular Characteristics of Clonable Pre-B Cells

    B Lymphocyte Genesis in the Bone Marrow

    Ontogeny and Differentiation of T Lymphocytes

    Role of Self Antigens in the Selection of the Developing T Cell Repertoire

    Thymic Influences on T Cell Development

    Role of Self-Reactivity in the Generation of the T Cell Specificity Repertoire

    Ontogeny of T Cell Receptors for Antigen

    Mature and Immature Thymocytes

    Structure and Function of Recognition Structures

    Diversification of Immunoglobulins and T Cell Receptors

    Immunoglobulins

    Three-Dimensional Structure and Specificity of Monoclonal Antilysozyme Antibodies

    Mutation and Selection of Antibodies

    The Influence of Somatic Mutation on the Immune Response

    Fab Assembly: An Analysis of Different CH1 : CL Combinations

    The T Cell Receptor Complex

    Expression of the Antigen-Specific MHC-Restricted T Cell Receptor

    Structural and Genetic Aspects of the T Cell Receptor-T3 Complex

    Genes Encoding the α-, β-, and γ-Chains of the Human T Cell Antigen Receptor

    Class I and Class II MHC Products

    Diversification of H-2 Genes through Recombination: A Study of Kb Mutants

    The Regulation of Ia Gene Transcription

    Antigen Presentation and Processing

    Antigen Presentation: Paradigm Lost?

    Interaction between Protein-Derived Immunogenic Peptides and Ia

    The Molecular Context of a Determinant Influences Its Dominant Expression in a T Cell Response Hierarchy through "Fine Processing"

    Antigen Internalization, Processing, and Recycling by Antigen-Presenting Cells

    Immunodominance of Amphipathic Peptides and Their Localization on the Cell Surface for Antigen Presentation to Helper T Cells

    The Complement System

    Molecular Mechanisms of Cytotoxicity: Comparison of Complement and Killer Lymphocytes

    Molecular Mechanisms in the Antibacterial Action of Complement

    Cell and Molecular Biology of Human Complement Receptors

    Molecular Biology of the Human Complement Class III Products of the MHC: Factor I and Its Cofactors

    Molecular Regulation of Complement Gene Expression

    Regulation of the Immune Response

    Epirestriction and a Specialized Subset of T Helper Cells are Key Factors in the Regulation of T Suppressor Cells

    B Cell Subsets and B Cell Activation

    Regulation of B Lymphocyte Activation: The Roles of Receptor Cross-Linkage and B Cell Stimulatory Factor-1 (BSF-1)

    B Cell Activation as a Consequence of Membrane Immunoglobulin-Mediated Antigen Presentation

    Regulation of Human B Cell Differentiation: Molecular Structure and Immunological Functions of Human B Cell Differentiation Factor (BSF-2)

    Idiotype-Directed Interactions During B Cell Ontogeny

    Characteristics of Ly 1 B Cells

    T Cell Subsets and T Cell Activation

    Multiple Signals Required in Cytolytic T Cell Responses

    Regulation of Activation of Cloned Murine T Cells

    The Generation of the Repertoire of T Cell Specificities and Functions: Toward a Consistent Model

    LM.19: A Novel Developmentally Regulated, Signal-Transducing Lymphocyte Antigen

    Adaptive Construction of the Immune Circuit

    Lymphokines and Growth Factors

    Lymphokines and Growth Factors: Interleukin-2 as a Prototype Lymphocytotrophic Hormone

    Interleukin-1

    Interferon-γ: Receptors and Effects on MHC Antigen Expression

    Molecular Biology of Interleukin-2 and Its Receptor: The Current Status

    Autoimmune Disorders

    Autoantibodies and Normal Antibodies

    The Use of Human T Cell Clones to Dissect HLA and Disease Associations

    Resistance to Experimental Autoimmunity Using T Lymphocyte Vaccines

    Molecular Genetics of Murine Lupus

    Idiotypes and Autoimmunity

    Congenital and Acquired Immunodeficiencies

    The Human T Lymphotropic Retroviruses and Human Immune Deficiency

    Cell Membrane Abnormalities Leading to Immune Deficiency

    Role and Molecular Biology of the Interleukin-2-Interleukin-2 Receptor System in Health and Disease

    Immunodeficiency Disease: Pathogenesis and Treatment

    Immune-Neuroendocrine Interactions

    Immune-Neuroendocrine Network

    Noradrenergic Sympathetic Innervation of Spleen and Lymph Nodes in Relation to Specific Cellular Compartments

    Transmembrane Signaling Mechanisms in Neuroendocrine Modulation of the Thymus-Dependent Immune System

    Bidirectional Pathways Between the Brain and Immune System: A Role for Thymosin Peptides

    A Molecular Basis for Bidirectional Communication Between the Immune and Neuroendocrine Systems

    Oncogenesis and Tumor Immunity

    Oncogene Activation by Chromosomal Translocations in B Cell-Derived Tumors

    Neoplastic Transformation of Lymphoid and Myeloid Cells

    Pathogenesis of Lymphoid and Myeloid Tumors

    Chronic Myelogenous Leukemia as a Model System for Stem Cell Growth Regulation and Hematolymphoid Development

    Mechanisms of Lymphoma Induction by Retroviruses

    Lessons from Translocations and Transgenic Mice: Constitutive c-myc Expression Predisposes to Neoplasia

    Induction, Expression, and Manipulation of Immunity to Tumors

    The Role of Major Histocompatibility Complex Class I Antigens in Antitumor Immunity

    Monoclonal Antibody Targeting of Cytotoxic Agents for Cancer Therapy

    Tumor-Specific Antigens on Experimental Tumors

    New Approaches to the Immunotherapy of Cancer Based on the Systemic Administration of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2

    Carcinoembryonic Antigen and Its Utility in the Diagnosis of Colonie Adenocarcinoma

    Response of the Host to the Environment

    Specificity and Immunogenicity

    Regulation of the Immune Response to Infectious Agents

    The Regulatory Role of Macrophages in Infection with Intracellular Pathogens

    The Role of Specific T Cell Subpopulations in Murine Cutaneous Leishmaniasis

    Cytotoxic T Cells in Influenza: Their Role and Viral Specificities

    Molecular Concepts of Bacterial Pathogenesis

    Mimicry by Virus of Host Molecules: Implications for Autoimmune Disease

    The Host-Parasite Relationship: Effector and Escape Mechanisms

    Cellular and Molecular Aspects of Host-Parasite Relationships

    Nonspecific Cytotoxic Factors and Resistance to Malaria

    Current Perspectives on Intestinal Responses to Parasitic Infection

    Immunity against Schistosomes in Murine Vaccine Models

    Development of a Sporozoite Vaccine against Malaria

    Mechanisms and Regulation of Immediate Hypersensitivity

    T Cell-Derived Factors and Fibroblast-Derived Factors Regulate the Growth and Differentiation of Mast Cells

    Growth and Differentiation of Mast Cells and Basophils

    T Cell Factors Involved in the Regulation of IgE Synthesis

    Biochemical Events Involved in IgE-Dependent Mediator Release

    A Cascade of Regulatory Factors Controls IgE Antibody Synthesis in Vivo and in Vitro

    Immunopharmacology: Concepts and Agents

    Mode of Action of Interleukins

    Radioprotection with Interleukin-1 : Comparison with Other Cytokines

    Anti-Interleukin-2 Receptor Monoclonal Antibody Treatment Prolongs Allograft Survival

    Neuroimmunopharmacological Activities of Muramyl Peptides

    Human Lymphocyte Subsets in Health and Disease

    T Cell Ontogeny: Acquisition of a Functional Program

    Subsets of Human Peripheral Blood Natural Killer Cells

    T Cell Subsets and Function

    Immunopathogenesis of the Acquired Immunodeficiency Syndrome (AIDS)

    A Postscript: The Response of the Host to the Environment

    Host-Graft Relationship

    Transplantation Immunobiology

    Tissue Transplantation

    Transplantation: Achievements and Challenges Outstanding

    The Role and Mechanism of Action of Dendritic Cells in Transplantation Immunity

    Suppressor Cells and Soluble Transplantation Antigens in Tolerance

    Natural Suppressor Cell Systems

    Active and Passive Antigen Presentation: Its Role in the Induction of Tissue Immunity and Allograft Tolerance

    Reproduction and Embryonic Development

    Antigen Expression at Human Maternal-Fetal Interfaces

    Role of Cell Surface Molecules in Mammalian Development

    Ontogeny of the Immune System in Anuran Amphibians

    Decidua-Associated Suppressor Cells and Suppressor Factors Regulating Interleukin-2: Their Role in the Survival of the "Fetal Allograft"

    Beyond the Immune System: The Immunotrophic Role of T Cells in Organ Generation and Regeneration

    Concluding Remarks

    Index

Product details

  • No. of pages: 1174
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: January 1, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9781483276106

About the Editors

B Cinader

Richard G. Miller

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