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Progress in Heterocyclic Chemistry - 1st Edition - ISBN: 9780081000243, 9780081000472

Progress in Heterocyclic Chemistry, Volume 27

1st Edition

Series Volume Editors: Gordon Gribble John Joule
Hardcover ISBN: 9780081000243
eBook ISBN: 9780081000472
Imprint: Elsevier
Published Date: 1st October 2015
Page Count: 640
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Table of Contents

    <li>Foreword</li> <li>Editorial Advisory Board Members Progress in Heterocyclic Chemistry</li> <li>Chapter 1. Propargyl Vinyl Ethers as Powerful Starting Points for Heterocycle Synthesis<ul><li>1.1. Introduction</li><li>1.2. Synthesis of Furans and Pyrroles via Propargyl Claisen Rearrangement</li><li>1.3. Synthesis of 1,3-Oxazolidines via Microwave Synthesis</li><li>1.4. Synthesis of 2<span class="italic">H</span>-Pyrans and 1,2-Dihydropyridines</li><li>1.5. Summary</li></ul></li> <li>Chapter 2. Recent Progress of Phosphonium Coupling in Heterocyclic and Medicinal Chemistry<ul><li>2.1. Introduction</li><li>2.2. Discovery of Phosphonium Coupling</li><li>2.3. Phosphonium Coupling for Direct Amination</li><li>2.4. Phosphonium Coupling for Direct Etherification</li><li>2.5. Phosphonium Coupling for Direct Thioetherification</li><li>2.6. Phosphonium Coupling for Direct Alkylation</li><li>2.7. Phosphonium Coupling for Direct Arylation</li><li>2.8. Phosphonium Coupling for Direct Alkynylation</li><li>2.9. Phosphonium Coupling for Nucleoside Chemistry</li><li>2.10. Summary</li></ul></li> <li>Chapter 3. Three-Membered Ring Systems<ul><li>3.1. Introduction</li><li>3.2. Epoxides</li><li>3.3. Aziridines</li></ul></li> <li>Chapter 4. Four-Membered Ring Systems<ul><li>4.1. Introduction</li><li>4.2. Azetidines, Azetines, and Related Systems</li><li>4.3. Monocyclic 2-Azetidinones (&#x3B2;-Lactams)</li><li>4.4. Fused and Spirocyclic &#x3B2;-Lactams</li><li>4.5. Oxetanes, Dioxetanes, and 2-Oxetanones (&#x3B2;-Lactones)</li><li>4.6. Thietanes and Related Systems</li><li>4.7. Silicon and Phosphorus Heterocycles: Miscellaneous</li></ul></li> <li>Chapter 5.1. Five-Membered Ring Systems: Thiophenes and Se/Te Derivatives<ul><li>5.1.1. Introduction</li><li>5.1.2. Synthesis of Thiophenes, Selenophenes, and Tellurophenes</li><li>5.1.3. Elaboration of Thiophenes and Benzothiophenes</li><li>5.1.4. Synthesis of Thiophenes, Selenophenes, and Tellurophenes for the Use in the Material Sciences</li><li>5.1.5. Thiophene, Selenophene, and Tellurophene Derivatives in Medicinal and Environmental Chemistry</li></ul></li> <li>Chapter 5.2. Five-Membered Ring Systems: Pyrroles and Benzo Analogs<ul><li>5.2.1. Introduction</li><li>5.2.2. Synthesis of Pyrroles</li><li>5.2.3. Reactions of Pyrroles</li><li>5.2.4. Synthesis of Indoles</li><li>5.2.5. Reactions of Indoles</li><li>5.2.6. Isatins, Oxindoles, Indoxyls, and Spirooxindoles</li><li>5.2.7. Carbazoles</li><li>5.2.8. Azaindoles</li><li>5.2.9. Isoindoles</li></ul></li> <li>Chapter 5.3. Five-Membered Ring Systems: Furans and Benzofurans<ul><li>5.3.1. Introduction</li><li>5.3.2. Reactions</li><li>5.3.3. Synthesis</li></ul></li> <li>Chapter 5.4. Five-Membered Ring Systems: With More than One N Atom<ul><li>5.4.1. Introduction</li><li>5.4.2. Pyrazoles and Ring-Fused Derivatives</li><li>5.4.3. Imidazoles and Ring-Fused Derivatives</li><li>5.4.4. 1,2,3-Triazoles and Ring-Fused Derivatives</li><li>5.4.5. 1,2,4-Triazoles and Ring-Fused Derivatives</li><li>5.4.6. Tetrazoles and Ring-Fused Derivatives</li></ul></li> <li>Chapter 5.5. Five-Membered Ring Systems: With N and S Atom<ul><li>5.5.1. Introduction</li><li>5.5.2. Thiazoles</li><li>5.5.3. Isothiazoles</li></ul></li> <li>Chapter 5.6. Five-Membered Ring Systems: With O and S (Se, Te) Atoms<ul><li>5.6.1. 1,3-Dioxoles and Dioxolanes</li><li>5.6.2. 1,3-Dithioles and Dithiolanes</li><li>5.6.3. 1,3-Oxathioles and Oxathiolanes</li><li>5.6.4. 1,2-Dioxolanes</li><li>5.6.5. 1,2-Dithioles and Dithiolanes</li><li>5.6.6. 1,2-Oxaselenolanes</li><li>5.6.7. Three Heteroatoms</li></ul></li> <li>Chapter 5.7. Five-Membered Ring Systems: With O and N Atoms<ul><li>5.7.1. Isoxazoles</li><li>5.7.2. Isoxazolines</li><li>5.7.3. Isoxazolidines</li><li>5.7.4. Oxazoles</li><li>5.7.5. Oxazolines</li><li>5.7.6. Oxazolidines</li><li>5.7.7. Oxadiazoles</li></ul></li> <li>Chapter 6.1. Six-Membered Ring Systems: Pyridine and Benzo Derivatives<ul><li>6.1.1. Introduction</li><li>6.1.2. Overview of Pyridine and (Iso)quinoline Uses</li><li>6.1.3. Synthesis of Pyridines</li><li>6.1.4. Reactions of Pyridines</li><li>6.1.5. Synthesis of Isoquinolines</li><li>6.1.6. Reactions of Isoquinolines</li></ul></li> <li>Chapter 6.2. Six-Membered Ring Systems: Diazines and Benzo Derivatives<ul><li>6.2.1. Introduction</li><li>6.2.2. Pyridazines and Benzo Derivatives</li><li>6.2.3. Pyrimidines and Benzo Derivatives</li><li>6.2.4. Pyrazines and Its Benzo Derivatives</li></ul></li> <li>Chapter 6.3. Triazines and Tetrazines<ul><li>6.3.1. Triazines</li><li>6.3.2. Tetrazines</li></ul></li> <li>Chapter 6.4. Six-Membered Ring Systems: With O and/or S Atoms<ul><li>6.4.1. Introduction</li><li>6.4.2. Heterocycles Containing One Oxygen Atom</li><li>6.4.3. Heterocycles Containing One or Two Sulfur Atoms</li><li>6.4.4. Heterocycles Containing Two or More Oxygen Atoms</li><li>6.4.5. Heterocycles Containing Both Oxygen and Sulfur in the Same Ring</li></ul></li> <li>Chapter 7. Seven-Membered Rings<ul><li>7.1. Introduction</li><li>7.2. Seven-Membered Systems Containing One Heteroatom</li><li>7.3. Seven-Membered Systems Containing Two Heteroatoms</li><li>7.4. Seven-Membered Systems Containing Three or More Heteroatoms</li><li>7.5. Future Directions</li></ul></li> <li>Chapter 8. Eight-Membered and Larger Rings<ul><li>8.1. Introduction</li><li>8.2. Carbon&#x2013;Oxygen Rings</li><li>8.3. Carbon&#x2013;Nitrogen Rings</li><li>8.4. Carbon&#x2013;Sulfur Rings</li><li>8.5. (Carbon&#x2013;Nitrogen)&#x2013;(Carbon&#x2013;Oxygen) Rings</li><li>8.6. Carbon&#x2013;Nitrogen&#x2013;Oxygen Rings</li><li>8.7. Carbon&#x2013;Nitrogen&#x2013;Sulfur/Selenium Rings</li><li>8.8. Carbon&#x2013;Oxygen&#x2013;Sulfur Rings</li><li>8.9. Carbon&#x2013;Nitrogen&#x2013;Metal Rings</li></ul></li> <li>Index</li>


Progress in Heterocyclic Chemistry (PHC), Volume 27, is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists.

The highlight chapters in Volume 27 are all written by leading researchers and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2014. Additional articles in this volume are “The Use of Propargyl Vinyl Ethers in Heterocycle Synthesis” and “Recent Progress of Phosphonium Coupling in Heterocyclic and Medicinal Chemistry."

As with previous volumes in the series, Volume 27 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way.

Key Features

  • Recognized as the premiere review of heterocyclic chemistry
  • Includes contributions from leading researchers in the field
  • Provides a systematic survey of the important 2014 heterocyclic chemistry literature
  • Includes articles on new developing topics of interest to heterocyclic chemists


Organic chemists, academic and industrial chemists, as well as advanced students


No. of pages:
© Elsevier 2015
1st October 2015
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Series Volume Editors

Gordon Gribble

Gordon Gribble is the Dartmouth Professor of Chemistry at Dartmouth College, Hanover, USA. His research program covers several areas of organic chemistry, most of which involve synthesis, including novel indole chemistry, triterpenoid synthesis, DNA intercalation, and new synthetic methodology. Prof Gribble also has a deep interest in naturally occurring organohalogen compounds, and in the chemistry of wine and wine making.

Affiliations and Expertise

Professor of Chemistry, Department of Chemistry, Dartmouth College, Hanover, NH, USA

John Joule

John Arthur Joule did his BSc, MSc, and PhD degrees at The University of Manchester, obtaining his PhD in 1961. He then undertook post-doctoral work at Princeton University and Stanford University, before joining the academic staff of the Chemistry Department at The University of Manchester in 1963, where he is currently a Professor. In 1996 he received an RSC Medal for Heterocyclic Chemistry.

Affiliations and Expertise

Emeritus Professor, The University of Manchester, UK