This volume of Progress in Heterocyclic Chemistry (PHC) is the twelfth annual review of the literature, covering the work published on most of the important heterocyclic ring systems during 1999, with inclusions of earlier material as appropriate. As in PHC-11, there are also three specialized reviews in this year's volume. In the inaugural chapter, Michael Groziak revitalizes the field of boron heterocycles, a relatively obscure class of heterocycles, but with a promising future. Heterocyclic phosphorus ylides are similarly a little known but useful class of compounds and Alan Aitken and Tracy Massil have provided a comprehensive review of them in Chapter 2. In Chapter 3 Jack Li discusses the remarkably versatile palladium chemistry in pyridine alkaloid synthesis.

The subsequent chapters deal with recent advances in the field of heterocyclic chemistry arranged by increasing ring size and with emphasis on synthesis and reactions.


For academic and industrial chemists and advanced students interested in heterocyclic chemistry.

Table of Contents

Boron Heterocycles as Platforms for Building New Bioactive Agents (M.P. Groziak). Heterocyclic Phosphorus Ylides (R.A. Aitken and T. Massil). Palladium Chemistry in Pyridine Alkaloid Synthesis (J.J. Li). Three- and Four-Membered Ring Systems. Three-Membered Ring Systems (A. Padwa and S.S. Murphree). Four-Membered Ring Systems (L.K. Mehta and J. Parrick). Five-Membered Ring Systems. Thiophenes & Se, Te, Analogs (E.T. Pelkey). Pyrroles and Benzo Derivatives (D.M. Ketcha). Furans and Benzofurans (S. Greve and W. Friedrichsen). With More than One N Atom (L. Yet). With N & S (Se) Atoms (P.A. Bradley and D.J. Wilkins). With O & S (Se, Te) Atoms (R.A. Aitken). With O & N Atoms (T.L. Gilchrist). Six-Membered Ring Systems. Pyridines and Benzo Derivatives (R.D. Larsen and J.-F. Marcoux). Diazines and Benzo Derivatives (B.R. Lahue and J.K. Snyder). Triazines, Tetrazines and Fused Ring Polyaza Systems (C. Ochoa and P. Goya). With O and/or S Atoms (J. D. Hepworth and B.M. Heron). Seven-Membered Rings (D.J. LeCount). Eight-Membered and Larger Rings (G.R. Newkome).


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About the authors

G.W. Gribble

Affiliations and Expertise

Department of Chemistry, Dartmouth College, Hanover, New Hampshire, USA

Thomas L. Gilchrist

Affiliations and Expertise

The Robert Robinson Laboratories, University of Liverpool, UK