Progress in Chemical Toxicology

Progress in Chemical Toxicology, Volume 3 explores the developments in methods and instrumentation for toxicological analyses. This book is composed of eight chapters, and begins with a description of the pharmacologic and physiologic effects of aliphatic alcohols. The succeeding chapter deals with the methods of analysis of various volatile poisons, such as halogenated aliphatic compounds, aromatic hydrocarbons, and acid compounds. A chapter focuses on the methods of determination and classic procedures for carbon monoxide analysis in breath and blood. These topics are followed by discussions on the development of spectrochemical methods chemical and radiochemical methods of determination of radionuclides in human bones and tissues; and the toxic effects of combined drug action. The last chapter examines the poison residue occurrence in human tissues. This book is of great value to toxicologists and public health workers and researchers.

Contributors

Preface

Contents of Other Volumes

Aliphatic Alcohols

I. Introduction

II. "Endogenous" Alcohols

III. Distribution of Absorbed Alcohol

IV. Fate of Absorbed Alcohol

V. Pharmacological and Physiological Effects

VI. Post-mortem Changes in Cadaver Blood

VII. Analytical Methods for Body Alcohol

VIII. Investigations of the Accuracy of Analytical Methods

IX. Other Aliphatic Alcohols

References

Volatile Toxic Compounds

I. Introduction

II. Halogenated Aliphatic Compounds

III. Aromatic Hydrocarbons

IV. Volatile Acidic Compounds

References

Methods for the Determination of Carbon Monoxide

I. Introduction

II. Preparation of Carbon Monoxide Standard Mixtures

III. Collection of Air and Breath Samples

IV. Analysis of Air and Breath Samples

V. Analysis of Blood Samples

References

Application of Gas Chromatography to Toxicology

I. Introduction

II. Detectors

III. Columns

IV. Qualitative Techniques

V. Analytical Procedures

References

Developments in Spectrography: Spectrochemical Methods

I. Introduction

II. Equipment and Materials

III. Procedures

References

Detection of Radionuclides of Biological Interest in Human Bones and Tissues

I. Introduction

II. Chemical Processing and Separation of Radionuclides in Biological Material

III. Chemical Separation and Determination of Radionuclides

IV. Radiochemical Determination of Strontium-90 and Strontium-89

V. Radiochemical Determination of Cesium-137

VI. Radiochemical Determination of Iodine-131

VII. Radiochemical Determination of Radium-226

VIII. Thorium (Thorotrast)

IX. Radiochemical Determination of Uranium

X. Radiochemical Determination of Plutonium-239

XI. Instrumentation

XII. Results of Measurements

References

Combined Action of Drugs with Toxicological Implications—Part I

I. Introduction

II. Factors Affecting Duration of Drug Action

III. Decreased Duration of Combined Drug Action

IV. Increased Duration of Combined Drug Action

References

Poison Residues in Human Tissues

I. Introduction

II. Salicylates

III. Barbiturates

IV. Chloral Hydrate

V. Paraldehyde

VI. Cyanide

VII. Tranquilizers

VIII. Boric Acid

IX. Metallic Poisons

References

Author Index

Subject Index