This volume provides the most recent insight into how abnormalities in the regulation of cell death lead to a variety of diseases. Each chapter in this book is written by an internationally recognized expert on the role of aberrant cell death in the pathogenesis of a particular disease. In addition to various types of cancer and neurodegenerative disorders, this book covers diseases ranging from arthritis to cardiovascular disease to diabetes. The chapters each integrate information obtained from patients with data obtained in experimental models of the disease to arrive at an emerging view of the pathogenic mechanisms of the disease. Applications of this fundamental knowledge to prevention and treatment of the diseases are considered. When taken together with Cell Death, Volume 1, this title will provide graduate students, postdocs and senior investigators in an array of biomedical disciplines invaluable resource for their pursuit of the causes and cures of many different human diseases.

Table of Contents

Preface. Apoptosis in Breast Cancer (H. Werner, Y. Oh, C.T. Roberts, Jr.). Apoptotic Pathways in Prostate Cancer (S.R. Denmeade, B. Tombal, J.T. Isaacs). Programmed Cell Death in the Pathogenesis of Autoimmune Diabetes (C. Polychronakos). Apoptosis in Arthritis - Pathogenesis and Therapeutic Intervention (T. Hasunuma, T. Kato, T. Kobata, K. Nishioka). Apoptosis in HIV Disease Pathogenesis (A. Nath). Apoptosis and Cerebral Ischemia (M. Endres, L. Hirt, M.A. Moskowitz). Neuronal Apoptosis and the Pathogenesis of Alzheimer's and Parkinson's Diseases (M.P. Mattson, Qing Guo, Wenzhuan Duan, Sic L. Chan). Apoptosis in Huntington Disease and Animal Models (V.E. Koliatsos, C. Portera-Cailliau, G. Schilling, D.B. Borchelt, M.W. Becher, C.A. Ross). Apoptosis in Motor Neuron Degenerative Diseases (W. A. Pedersen, I. Kruman, M.P. Mattson). Apoptosis and Bone Disease (C.S. Adams, W.E. Horton, Jr.). Contributor Addresses.


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© 2001
Elsevier Science
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About the editors

S. Estus

Affiliations and Expertise

Sanders-Brown Research Center on Aging, 101 Sanders-Brown Building, University of Kentucky, Lexington, KY 40536, USA

M.P. Mattson

Affiliations and Expertise

Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA

V. Rangnekar

Affiliations and Expertise

Urology Department, 303 Combs Cancer Building, University of Kentucky, Lexington, KY 40536, USA