Prognostic Epigenetics

Prognostic Epigenetics

1st Edition - November 1, 2019

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  • Editor: Shilpy Sharma
  • eBook ISBN: 9780128142608
  • Hardcover ISBN: 9780128142592

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This volume provides comprehensive information on how mapping an individual’s epigenome can be medically relevant and holds the potential to improve preventive medicine and precision therapeutics at an early-stage (prior to disease onset). In order to advance clinical adoption of the recently developed epigenetic approaches, it is necessary for translational scientists, clinicians, and students to gain a better understanding about epigenetic mechanisms that are associated with a particular disorder; and to be able to effectively identify biomarkers that can be applied in drug development and for better diagnosis and prognosis of diseases. Prognostic Epigenetics is the most-inclusive volume to-date specifically dedicated to epigenetic markers that have been developed for prognosis of diseases, recent advances in this field, the clinical implementation of this research, and the future outlook.

Key Features

  • Compiles all known information on prognostic epigenetics and its role in preventive medicine and drug discovery
  • Covers the basic functionality of epigenetic mechanisms involved in early disease prognosis and diagnosis, and provides tools for the identification and development of these biomarkers for a wide range of diseases
  • Enables clinicians, researchers, and pharmacologists to improve preventive medicine and precision therapeutics throughout a person’s lifetime
  • Features chapter contributions from leading international researchers


Translational researchers, clinicians and graduate students in genomic medicine, epigenetics, endocrinology, nutrition, oncology, pathology, and biotechnology; life science researchers; developmental biologists; MDs/clinicians, medical students and residents; pharmacologists in industry and academia; primary care doctors, medical chemists, molecular biologists, genetic counselors

Table of Contents

  • 1. It is more than simple genes: The epigenome is more powerful than your genome
    2. Diagnostic, prognostic and therapeutic potential of the inter-individual variability in the major epigenetic processes: A Clinical Prospective
    3. Technological advances in studying epigenetics biomarkers for clinical research
    4. DNA methylation and Chromatin remodeling: Potential prognostic biomarker for disease diagnosis
    5. Use of post-translational histone modifications for disease diagnosis
    6. Use of non-coding RNAs as Clinical Biomarkers for disease diagnosis
    7. The Epigenetic Landscape in Neurological and Neurodegenerative Disorders
    8. Epigenetic Biomarkers in Asthma and Allergy
    9. Epigenetics Biomarkers in Metabolic syndrome and Obesity
    10. Chromatin landscape and Epigenetic biomarkers for clinical diagnosis and prognosis of Type 2 Diabetes mellitus
    11. Epigenetic biomarkers in Cardiovascular disorders
    12. Epigenetic biomarkers in Cancer
    13. Epigenetics in Infectious diseases
    14. Epigenetics of autoimmune disorders
    15. Epigenetics of Birth defects
    16. Epigenetics of adverse pregnancy outcomes
    17. Epigenetic landscape of Infertility
    18.  Epigenetic landscape of polycystic ovarian syndrome
    19. Epigenetic biomarkers in ocular disorders
    20. Epigenetic biomarkers in personalized medicine
    21. Conclusions and Perspectives. Future Challenges and Prospects for Prognostic Epigenetics and personalized epigenomics

Product details

  • No. of pages: 442
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: November 1, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128142608
  • Hardcover ISBN: 9780128142592

About the Series Volume Editor

Shilpy Sharma

Dr. Shilpy Sharma, PhD, is an Assistant Professor at the Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune) in Pune, Maharashtra, India. She has served as a Post-Doctoral Fellow in the Department of Pharmacology at University of Michigan and as a Post-Doctoral Fellow at the Department of Surgery, University of Chicago Medical Center. Dr. Sharma’s research focuses on identification of prognostic biomarkers for complex disorders including cancer, diabetes, and asthma; and infectious diseases.

Affiliations and Expertise

Assistant Professor at the Department of Biotechnology, Savitribai Phule Pune University, India

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