Whilst following in the footsteps of previous volumes by presenting comprehensive reviews of drug substances and additional materials, this title also heralds a significant expansion of the scope of the series. Traditional contributions are now augmented by publication of critical review chapters that summarize information related to the characterization of drug substances and excipients. This change meets the needs of the pharmaceutical community and allows the development of a timely vehicle for publishing review materials on this topic. While offering comprehensive and specialised chapters, Profiles of Drug Substances, Excipients and Related Methodology, Volume 32 also presents a methodology review article on the validation of chromatographic methods of analysis, as well as a summary of the publications in 2004 that dealt with polymorphism and solvatomorphism.

Key Features

* Presents comprehensive reviews covering all aspects of drug development and formulation of drugs * Now encompassing critical review chapters * Meets the information needs of the drug development community


Medicinal, pharmaceutical, and analytical chemists; pharmacologists

Table of Contents

Profiles of Drug Substances
1. Miconazole Nitrate
Comprehensive Profile (Abdullah A. Al-Badr).
2. Niclosamide
Comprehensive Profile (Badraddin M.H. Al-Hadiya).
3. Oxytetracycline
Analytical Profile (Mochammad Yuwono, Gunawan Indrayanto).
4. Penicillamine
4A Physical Profile
4B Analytical Profile
4C ADME Profile
(Abdulrahman Al-Majed et al.).
5. Primaquine Diphosphate
Comprehensive Profile (Abdullah A. Al-Badr).
6. Valproic Acid and Sodium Valproate
Comprehensive Profile (Ibrahim A. Alsarra et al.).
Related Methodology Review Article
7. Validation of Chromatographic Methods of Analysis (Mochammad Yuwono, Gunawan Indrayanto).
Annual Review
8. Polymorphism and Solvatomorphism 2004 (Harry G. Brittain).


No. of pages:
© 2005
Academic Press
Electronic ISBN:
Print ISBN:

About the editor

Harry Brittain

Center for Pharmaceutical Physics, Milford, NJ, USA