Profiles of Drug Substances, Excipients, and Related Methodology

Profiles of Drug Substances, Excipients, and Related Methodology

1st Edition - March 28, 2022

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  • Editor: Abdulrahman Al-Majed
  • eBook ISBN: 9780323854832
  • Hardcover ISBN: 9780323854825

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Description

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 47 covers all aspects of drug development and formulation of drugs, meeting the information needs of the drug development community that are essential to all phases of pharmaceutical development. This updated release includes comprehensive profiles of five drug compounds: Vinpocetine; Loratadine; Ticagrelor; Lodenafil; Danazol. The volume also contains a chapter reviewing “Application of Chemometrics using direct Spectroscopic methods as a QC tool in Pharmaceutical Industry and their Validation.”

Key Features

  • Contains contributions from leading authorities
  • Presents an excellent overview of the physical, chemical and biomedical properties of regularly prescribed drugs
  • Contains a cumulative index for easy access to information

Readership

Pharmacists; Pharmaceutical, medicinal, and analytical chemists; Pharmacologists; physicians

Table of Contents

  • Cover
  • Title Page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter One: Vinpocetine (A comprehensive profile)
  • Abstract
  • 1: Description
  • 2: Methods of preparation
  • 3: Physical characteristics
  • 4: Thermal behavior
  • 5: Spectroscopy
  • 6: Methods of analysis
  • 7: Stability
  • 8: Clinical applications
  • 9: Pharmacokinetics and mechanism of action
  • References
  • Chapter Two: Loratadine
  • Abstract
  • 1: Physical profiles of drug substances and excipients
  • 2: Analysis methods
  • References
  • Chapter Three: Ticagrelor
  • Abstract
  • 1: Introduction
  • 2: Mode of action
  • 3: Pharmacokinetics
  • 4: Indications
  • 5: Chemical structure
  • 6: Synthesis
  • 7: Physical characteristics
  • 8: Methods of analysis
  • Acknowledgment
  • References
  • Chapter Four: Lodenafil
  • Abstract
  • 1: Description
  • 2: Methods of preparation of lodenafil
  • 3: Physical characteristics
  • 4: Method of analysis
  • 5: Stability
  • 6: Clinical applications
  • References
  • Chapter Five: Danazol
  • Abstract
  • 1: Description
  • 2: Uses and applications
  • 3: Methods of preparations
  • 4: Physical characteristics
  • 5: Methods of analysis
  • 6: Biological investigations
  • 7: Stability
  • 8: Toxicity
  • 9: Reviews
  • Acknowledgments
  • References
  • Chapter Six: Application of chemometrics using direct spectroscopic methods as a QC tool in pharmaceutical industry and their validation
  • Abstract
  • 1: Introduction
  • 2: Validation of pharmaceutical's chemometrics method of analysis
  • 3: Principles, applications and validation of direct spectroscopic methods according to general chapters of USP43-NF38
  • 4: Application of chemometrics for evaluation of the finished products and the processes of production
  • 5: Application of chemometrics for evaluation of the incoming raw materials
  • 6: Summary and recommendations
  • Acknowledgments
  • References
  • Cumulative index

Product details

  • No. of pages: 398
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: March 28, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323854832
  • Hardcover ISBN: 9780323854825

About the Editor

Abdulrahman Al-Majed

Professor Abdulrahman AlMajed obtained a Bachelor of Pharmaceutical Sciences from College of Pharmacy, King Saud University, Riyadh, Saudi Arabia in 1990 and a Ph.D. in the field of Pharmaceutical analytical Chemistry from the University of Bradford, UK, in 1997. He also received a Bachelor of Legislation from College of Legislation, Imam Mohammed Bin Saud University, Riyadh, Saudi Arabia. He was appointed as assistance professor in Pharmaceutical Chemistry Department at College of Pharmacy, King Saud University in 1998. He was promoted to the rank of associated professor in 2003. He was a head of Pharmaceutical Chemistry Department (2005-2019) (2015-2017). Since 2009, he is full professor of Pharmaceutical Analytical Chemistry. He was assistance secretary of Scientific Council at King Saud University and he is presently a member of Scientific Council in Princess Nourah Bint Abdul Rahman University and in Jouf University, Saudi Arabia. He also a member of Medical and health Sciences Committee of Qualification Recognition in Ministry of Education and a member of Patent Lawsuits Committee in Saudi Arabia. He is a member of several scientific and social Committees. He participated in several national and international conferences and symposia. Prof. Almajed has taught courses in the field of Pharmaceutical Analysis at both the undergraduate and postgraduate levels at College of Pharmacy. He is recently appointed as the Editor-In-Chief of the book series Profiles of Drug Substances, Excipients, and Related Methodology. He published 10 chapters in the series. Dr. AlMajed published over 65 research papers in the field of Pharmaceutical Analysis. His research is focused on determination and validation of pharmaceutical compounds in dosage forms or/and in biological fluids by analytical techniques including: HPLC, electrophoresis, spectrophotometry, spectrofluorometry, voltammetry. His research also includes resolution and quantitation of the R-(-)- and S-(+)- enantiomers of pharmaceutical compounds in dosage forms or/and in biological fluids using chiral stationary phases.

Affiliations and Expertise

Professor, Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Saudi Arabia

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