Processing and Presentation of Antigens

Processing and Presentation of Antigens

1st Edition - April 28, 1988

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  • Editor: Benvenuto Pernis
  • eBook ISBN: 9780323155274

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Description

Processing and Presentation of Antigens brings together the views of immunologists, biochemists, cell biologists, and virologists who have a common interest in the early phases of the immune response. Antigen processing and presentation comprise a series of events that are much more complex and sophisticated than had been thought for a long time, and constitute an essential part of the biology of the immune response to T-dependent protein antigens. The book is organized into seven parts. Part I discusses the major advances and insights in antigen processing, some results on the interaction of antigen with class II MHC molecules, and the precise mechanism involved in antigen processing. Part II presents papers on endosomes, lysosomes, and recycling. Part III deals with studies on presentation in the context of class I MHC molecules. The chapters in Part IV examine interactions of antigens with class II MHC molecules. Part V contains papers on macrophages and dendritic cells as accessory cells. Part VI examines antigen presentation by B cells. Part VII covers studies on T cells.

Table of Contents


  • Preface

    Part I. Introduction

    1. Processing of Native Antigen by Accessory Cells and Presentation of Membrane-Bound MHC-Associated Antigen to Specific T Cells

    Introduction

    Historical

    Antigen Processing

    Specific Interaction of Antigen with Class II MHC Molecules

    References

    Part II. Endosomes, Lysosomes, and Recycling

    2. Pinocytic Flow through Macrophages

    Constitutive Pinocytosis in Macrophages

    Stimulated Pinocytosis in Macrophages

    Some Speculations Regarding Mechanisms

    References

    3. Processing of Ligands in Macrophage Endosomes

    Introduction

    Intracellular Transport of Mannosylated Proteins in Macrophages

    References

    4. Intracellular Transport of Class II HLA Antigens

    Introduction

    Kinetics of HLA-DR Antigen Transport

    Interactions of Class II Antigens with the Endocytic Pathway

    Discussion

    References

    5. Endocytosis of the T4 Molecule

    Introduction

    Materials and Methods

    Results

    Conclusions

    References

    Part III. Presentation in the Context of Class I MHC Molecules

    6. Pathways of Viral Antigen Presentation in T Lymphocyte Recognition

    Introduction

    Experimental System

    Viral Infectivity and Target Cell Sensitization

    Presentation of Exogenous and Endogenous Antigen

    Receptor Engagement and T Lymphocyte Activation

    Conclusions

    References

    7. The Epitopes of Influenza Nucleoprotein Recognized by Cytotoxic T Lymphocytes Can Be Defined with Short Synthetic Peptides

    Introduction

    Results

    Discussion

    References

    8. Cytotoxic T Cell Recognition of the SV40 Tumor Antigen:

    A Note of Caution

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Part IV. Interactions of Antigens with Class II MHC Molecules

    9. Ia Structure and Immune Recognition

    Introduction

    Location of Ia Allelic Polymorphism

    Ia Expression Following Gene Transfer

    Discussion

    References

    10. The Role of MHC and Amphipathic Structures in T Cell Recognition: Features Determining Immunodominance

    Text

    References

    11. Pathways to Presentation

    Introduction

    Antigen Architecture

    References

    12. Antigen Presentation by Supported Planar Membranes Containing Purified Major Histocompatibility Complex Proteins

    Introduction

    Recognition System

    Supported Planar Membranes

    T Cell Responses to Supported Planar Membranes

    Containing I-A Molecules

    Biophysical Measurements on Supported Planar Membranes

    Conclusions

    References

    Part V. Macrophages and Dendritic Cells as Accessory Cells

    13. Antigen Presentation by Macrophages

    Antigen Processing

    A Membrane Interleukin-1 (IL-1)

    Antigen Presentation: IL-1 Requirements and Induction of IL-1

    References

    14. Antigen Presentation by Dendritic Cells

    Introduction

    The Stimulatory Capacity of DC during the Primary MLR

    DC as Stimulators of Other Primary Responses

    APC Requirements for Memory T Lymphocytes

    Antigen-Dependent and -Independent Clustering of APC and T Cells

    DC Function in Man

    Discussion

    References

    15. The Immunologic Properties of Epidermal Langerhans Cells

    Introduction

    Methods

    The Phenotype of LC in Epidermal Sheets and in EC Suspensions

    Immunologic Properties of Murine Epidermal LC

    Factors Underlying the Maturation of LC

    Discussion

    References

    16. VH Gene Expression by Nontransformed Pre-B Cells during Differentiation in Vitro

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    Part VI. Antigen Presentation By T Cells

    17. The Interaction between Immunogenic Peptides and Ia

    Introduction

    Characterization of Binding of OVA 323-339 to I-Ad

    Kinetics of Peptide-Ia Interaction

    Capacity of Antigen-Ia Complexes to Stimulate T Cells

    Patterns of Interaction between 11 Peptides and Iad and Iak

    Inhibition of Antigen Presentation by Unrelated Peptides

    Covalent Cross-linking of Peptides to Ia

    References

    18. On the Role of B Cell Surface Ig in Antigen Presentation to T Cells

    Introduction

    Antigen-Specific sIg Allows B Cells to Present Antigen Very Efficiently

    The Paradox of the Avidity of Antigen-Dependent

    T-B Interaction

    References

    19. The Role of Specific B Lymphocytes in Antigen Processing and Presentation to T Cells History

    General, Nonclonally Specific B Cell Antigen Presentation

    The Immunoglobulin-Dependent Pathway of Antigen Presentation

    Significance

    References

    20. The Role of Membrane Immunoglobulin in Antigen Presentation by B Lymphocytes

    Introduction

    Roles of IgM and IgD in Antigen Presentation

    Antigen Presentation by Small T Cells

    Effect of Membrane Ig Cross-Linking and Internalization on Membrane Ig-Mediated Antigen Presentation

    Receptor-Mediated Antigen Processing by Small B Cells

    References

    21. Selective Cooperation between T and B Clones Specific for the Same Macromolecular Antigen: Does Antibody Specificity Influence Antigen Processing?

    Introduction

    The Immunochemistry of ß-Galactosidase

    "Directional Help" in the Anti-GZ Response

    Paradox

    Paratope Effect on Processing

    In Vitro Digestion of Monoclonal Antibody-GZ Complexes

    Differential Response of GZ-Specific T Hybridoma Clones

    Confronted with Macrophages Exposed to a Panel of GZ-Monoclonal

    Antibodies Complexes

    Conclusion

    References

    22. Recycling of Histocompatibility Molecules and Antigen Presentation

    Introduction

    Intracellular Class I MHC

    Intracytoplasmic Events Necessary for the Presentation of Endogenously Synthesized Antigens by Class I MHC

    Intracellular Class II MHC Molecules

    Endocellular Production of Immunogenic Peptides in B Lymphocytes and Possible Sites of Formation of Class II

    MHC-Peptide Complexes

    Summary and Conclusions

    References

    Part VII. What do the T Cells see?

    23. Localization of Immune Receptor Recognition Sites on Major Histocompatibility Molecules through the Analysis of H-2Kb Mutants

    Introduction

    Selection of Somatic Cell Variants of H-2Kb

    In W/ro-Derived H-2Kb

    Structural Variants

    Analysis of Kb Mutant Molecules for the Localization of Immune Receptor Recognition Sites

    Summary

    References

    24. T Cell Recognition of Antigen and la Molecules Involves a Trimolecular Complex

    T Cell Recognition of Foreign Antigen Involves Three Components

    Effect of Varying Responding T Cell Number in a Proliferation Assay

    Antigen Dose-Response Curve Shifts Can Be Quantitated and Used to Analyze the Relative Avidity of the T Cell

    Receptor for Antigen-la

    Analysis of Antigen Dose-Response Curve Shifts in the Presence of Two Allelic Forms of the Ia Molecule

    Conclusions

    References

    25. Antigen-Presenting Cell Lysis: Role in Immune Responses and Effect on Quantitative Analyses of Antigen Presentation to T Cells

    Introduction

    Materials and Methods

    Results

    Discussion

    References

    26. Structure-Function Relationship in Human Class I HLA Molecules HLA Molecules

    Amino Acid Polymorphisms and CTL Variants

    Site-Directed Mutagenesis Using Mismatched Oligonucleotides

    Conclusions

    References

    Index








Product details

  • No. of pages: 338
  • Language: English
  • Copyright: © Academic Press 1988
  • Published: April 28, 1988
  • Imprint: Academic Press
  • eBook ISBN: 9780323155274

About the Editor

Benvenuto Pernis

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