- Focuses on metabolism of copper and manganese, which are found in Scrapie of sheep; BSE, the "Mad Cow" disease; and CJD, one of the human prion diseases
- Discusses the effects of copper on biochemical properties, prion proteins of brain cells and new techniques for their study
- Stems from the proceedings of the international workshop at Christ’s College, Cambridge University in 2001
Table of Contents
- Copper – prion protein, molecular interactions; Effects of copper on the cellular trafficking and biochemical properties of the prion protein; Tracing the copper binding to the murine prion protein; Co-ordinate binding of copper to prion protein; Oxidative stress, metal ions and neurodegenerative disease; Near infrared spectroscopy for non-destructive analysis of prion protein isoforms; Prion and Alzheimer diseases; The copper binding domain of the amyloid precursor protein of Alzheimer’s disease can modulate copper homeostasis and regulate amyloid AB production; Metals modulate the aggregation and neurotoxic properties of the prion peptide PrP106-126; Human CJD and trace elements; Metals and human prion disease; Disease progression and metal aberrations; Trace elements copper and manganese in soils; Future directions for copper and the prion protein.
- No. of pages: 266
- Language: English
- Copyright: © Woodhead Publishing 2002
- Published: October 1, 2002
- Imprint: Woodhead Publishing
- eBook ISBN: 9780857099914
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