Principles of Translational Science in Medicine
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Principles of Translational Science in Medicine

From Bench to Bedside

3rd Edition - July 15, 2021

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  • Editor: Martin Wehling
  • Hardcover ISBN: 9780128204931
  • eBook ISBN: 9780323999625

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Description

Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields.

Key Features

  • Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine
  • Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology
  • Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization

Readership

All biomedical researchers from preclinical to clinical scientists need to understand and apply translational science in medicine, which applies to scientists in pharmaceutical industry though almost all principles are applicable to device development. Additionally, academic researchers will need the book, as well

Table of Contents

  • Part I: Introduction
    1. Introduction and definitions
    2. Problems, challenges, and initiatives in translation
    Part II. Target identification and validation
    3. “Omics” translation: a challenge for laboratory medicine
    4. The power of genomics, metabolomics, and other omics for target identification and validation
    5. Potency analysis of cellular therapies: the role of molecular assays
    6. Translational pharmacogenetics: pharmacogenetically driven clinical decision making
    7. Tissue biobanks
    8. Animal models: value and translational potency
    9. Biomarkers in the context of health authorities and consortia
    10. Human studies as a source of target information
    11. Target profiling in terms of translatability and early translation planning
    Part III. Biomarkers as key elements of successful translation
    12. Biomarkers
    13. Genetics, molecular biomarkers, and artificial intelligence to improve diagnostic and prognostic efficacy
    14. Cardiovascular translational biomarkers: translational aspects of hypertension, atherosclerosis, and heart failure in drug development in the digital era
    15. Biomarkers in oncology
    16. Translational medicine in psychiatry: challenges and imaging biomarkers
    Part IV: Early clinical trial design
    17. Methodological studies
    18. The pharmaceutical research and development productivity crisis: can exploratory clinical studies be of any help?
    19. Adaptive trial design
    20. Combining regulatory and exploratory trials
    21. Accelerating proof of concept by smart early clinical trials
    Part V: Toxicology in translation
    22. Pharmaceutical toxicology
    23. Translational safety medicine
    Part VI: Special topics in translation
    24. Cancer vaccines: translational strategies
    25. Translational aspects of biologicals: monoclonal antibodies and antibody-drug conjugates as examples
    26. Orphan drugs: why is translation so successful?
    Part VII: Biostatistics and modelling
    27. Translational science biostatistics
    28. Computational biology and model-based approaches in translational medicine
    Part VIII. Legal aspects and special interest groups
    29. Intellectual property and innovation in translational medicine
    30. Translational research in the fastest-growing population: older adults
    Part IX. Integration and application of translational guidance
    31. Translational medicine: the changing role of big pharma
    32. Translational science in medicine: putting the pieces together-biomarkers, early human trials, networking, and translatability assessment
    33. Learning by experience

Product details

  • No. of pages: 494
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: July 15, 2021
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128204931
  • eBook ISBN: 9780323999625

About the Editor

Martin Wehling

Martin Wehling is the Managing Director at the Institute of Experimental and Clinical Pharmacology and Toxicology. Martin Wehling is Director in Clinical Pharmacology at Mannheim Medical Faculty, Mannheim University of Heidelberg, Mannheim, Germany.

Affiliations and Expertise

Managing Director, Institute of Experimental and Clinical Pharmacology and Toxicology, Director, Clinical Pharmacology, Mannheim Medical Faculty, Mannheim University of Heidelberg, Mannheim, Germany

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