Principles of Tissue Engineering

5th Edition - March 26, 2020
Editors: Robert Lanza, Robert Langer, Joseph P. Vacanti, Anthony Atala
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 1 8 4 2 2 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 1 4 0 1 - 5

Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fifth edition provides… Read more

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Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fifth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system.

As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future.

This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field.

INTRODUCTION TO TISSUE ENGINEERING1. From Mathematical Models to Clinical Reality 2. Stem Cells as Building Blocks 3. Moving into the Clinic 4. Tissue Engineering: Current Status and Future Perspectives PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION5. Molecular Biology of the Cell 6. Molecular Organization of Cells 7. The Dynamics of Cell-ECM Interactions, with Implications for Tissue Engineering 8. Matrix Molecules and Their Ligands 9. Morphogenesis and Tissue Engineering 10. Gene Expression, Cell Determination, Differentiation, and Regeneration PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT11. Engineering Functional Tissues: In Vitro Culture Parameters 12. Principles of Bioreactor Design for Tissue Engineering 13. Regulation of Cell Behavior by Extracellular Proteins 14. Cell and Matrix Dynamics in Branching Morphogenesis 15. Mechanobiology, Tissue Development and Organ Engineering PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS16. In Vivo Synthesis of Tissues and Organs PART FOUR: BIOMATERIALS IN TISSUE ENGINEERING17. Cell Interactions with Polymers 18. Polymer Scaffold Fabrication 19. Biodegradable Polymers 20. 3D Scaffolds PART FIVE: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES21. The Role of the Host Immune Response in Tissue Engineering and Regenerative Medicine 22. Tissue Engineering and Transplantation in the Fetus 23. in the Development of Immunoisolation Devices PART SIX: STEM CELLS24. Embryonic Stem Cells 25. Induced Pluripotent Stem Cells 26. Neonatal Stem Cells in Tissue Engineering 27. Embryonic Stem Cells as a Cell Source For Tissue Engineering 28. Postnatal Stem Cells in Tissue Engineering PART SEVEN: GENE THERAPY29. Gene Therapy 30. Gene Delivery into Cells and Tissues PART EIGHT: BREAST31. Breast Tissue Engineering: Reconstruction Implants and Three-Dimensional Tissue Test Systems PART NINE: CARDIOVASCULAR SYSTEM32. Progenitor Cells and Cardiac Homeostasis and Regeneration 33. Cardiac Tissue Engineering 34. Blood Vessels 35. Tissue-Engineering Heart Valves PART TEN: ENDOCRINOLOGY AND METABOLISM36. Generation of Pancreatic Islets from Stem Cells 37. Bioartificial Pancreas 38. Thymus and Parathyroid Organogenesis PART ELEVEN: GASTROINTESTINAL SYSTEM39. Stem Cells in the Gastrointestinal Tract 40. Liver Stem Cells 41. Hepatic Tissue Engineering PART TWELVE: HEMATOPOIETIC SYSTEM42. Hematopoietic Stem Cells 43. Blood Components from Pluripotent Stem Cells 44. Red Blood Cell Substitutes 45. Lymphoid Cells PART THIRTEEN: KIDNEY AND GENITOURINARY SYSTEM46. Stem Cells in Kidney Development and Regeneration 47. Tissue Engineering of the Kidney 48. Bladder and Urethra 49. Female Reproductive Organs 50. Male Reproductive Organs PART FOURTEEN: MUSCULOSKELETAL SYSTEM51. Mesenchymal Stem Cells in Musculoskeletal Tissue Engineering 52. Bone Regeneration 53. Tissue Engineering for Regeneration and Replacement of the Intervertebral Disc 54. Articular Cartilage Injury 55. Engineering Cartilage and Other Structural Tissues: Principles of Bone and Cartilage Reconstruction 56. Tendons and Ligament Tissue Engineering 57. Skeletal Tissue Engineering PART FIFTEEN: NERVOUS SYSTE58. Brain Implants 59. Brain-Machine Interfaces 60. Spinal Cord 61. Protection and Repair of Hearing PART SIXTEEN: OPHTHALMIC62. Stem Cells in the Eye 63. Corneal Replacement Tissue 64. Retinal Degeneration 65. Vision Enhancement Systems PART SEVENTEEN: ORAL/DENTAL APPLICATIONS66. Biological Tooth Replacement and Repair 67. Tissue Engineering in Oral and Maxillofacial Surgery 68. Periodontal Tissue Engineering PART EIGHTEEN: RESPIRATORY SYSTEM69. Tissue Engineering for the Respiratory Epithelium: Cell-Based Therapies for Treatment of Lung Disease 70. Lung Tissue Engineering PART NINETEEN: SKIN71. Cutaneous Epithelial Stem Cells 72. Wound Repair: Basic Biology to Tissue Engineering 73. Bioengineered Skin Constructs PART TWENTY: TISSUE-ENGINEERED FOOD74. Principles of Tissue Engineering for Food 75. Prospects for In Vitro Cultured Meat PART TWENTYONE: EMERGING TECHNOLOGIES76. 3D Bioprinting 77. Biofabricated 3D Tissue Models 78. Body-on-a-Chip 79. Monitoring and Real-Time Control of Tissue Engineered Systems 80. Bio-Manufacturing for Regenerative Medicine PART TWENTYTWO: CLINICAL EXPERIENCE81. Tissue-Engineered Skin Products 82. Tissue-Engineered Cartilage Products 83. Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopedic and Craniofacial Surgery 84. Tissue-Engineered Cardiovascular Products 85. Tissue-Engineered Organs PART TWENTYTHREE: REGULATION, COMMERCIALIZATION AND ETHICS86. The Regulatory Process from Concept to Market 87. Business Issues 88. Ethical Issues

Robert Lanza

Robert Lanza is an American scientist and author whose research spans the range of natural science, from biology to theoretical physics. TIME magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” He has hundreds of scientific publications and over 30 books, including definitive references in the fields of stem cells, tissue engineering, and regenerative medicine. He’s a former Fulbright Scholar and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman (known for his work on the biological basis of consciousness) and Rodney Porter. He also worked closely (and co-authored papers in Science on self-awareness and symbolic communication) with noted Harvard psychologist BF Skinner. Dr. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

Affiliations and expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

Robert Langer

Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies.

Affiliations and expertise

Massachusetts Institute of Technology, Cambridge, USA

Joseph P. Vacanti

Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children’s Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children’s Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan.

Affiliations and expertise

Harvard Medical School and the Massachusetts General Hospital, Boston, USA

Anthony Atala

Anthony Atala, MD, is the G. Link Professor and Director of the Wake Forest Institute for Regenerative Medicine, and the W. Boyce Professor and Chair of Urology. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. Fifteen applications of technologies developed in Dr. Atala's laboratory have been used clinically. He is Editor of 25 books and 3 journals. Dr. Atala has published over 800 journal articles and has received over 250 national and international patents. Dr. Atala was elected to the Institute of Medicine of the National Academies of Sciences, to the National Academy of Inventors as a Charter Fellow, and to the American Institute for Medical and Biological Engineering. Dr. Atala has led or served several national professional and government committees, including the National Institutes of Health working group on Cells and Developmental Biology, the National Institutes of Health Bioengineering Consortium, and the National Cancer Institute’s Advisory Board. He is a founding member of the Tissue Engineering Society, Regenerative Medicine Foundation, Regenerative Medicine Manufacturing Innovation Consortium, Regenerative Medicine Development Organization, and Regenerative Medicine Manufacturing Society.

Affiliations and expertise

Professor, Wake Forest Institute for Regenerative Medicine, USA