Principles of Tissue Engineering - 5th Edition - ISBN: 9780128184226

Principles of Tissue Engineering

5th Edition

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Editors: Robert Lanza Robert Langer Joseph Vacanti Anthony Atala
Hardcover ISBN: 9780128184226
Imprint: Academic Press
Published Date: 30th March 2020
Page Count: 1558
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Description

Now in its fifth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fifth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system.

As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future.

This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and the application of tissue-engineering techniques for food production – is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the emerging technologies in the field.

Key Features

  • Organized into twenty-three parts, covering the basics of tissue growth and development, approaches to tissue and organ design, and a summary of current knowledge by organ system
  • Introduces a new section and chapters on emerging technologies in the field
  • Full-color presentation throughout

Readership

Scientists involved in stem cell engineering and gene editing, and individuals of any medical subspecialty

Table of Contents

INTRODUCTION TO TISSUE ENGINEERING
1. From Mathematical Models to Clinical Reality 
2. Stem Cells as Building Blocks 
3. Moving into the Clinic 
4. Tissue Engineering: Current Status and Future Perspectives 
PART ONE: THE BASIS OF GROWTH AND DIFFERENTIATION
5. Molecular Biology of the Cell 
6. Molecular Organization of Cells 
7. The Dynamics of Cell-ECM Interactions, with Implications for Tissue Engineering 
8. Matrix Molecules and Their Ligands 
9. Morphogenesis and Tissue Engineering 
10. Gene Expression, Cell Determination, Differentiation, and Regeneration 
PART TWO: IN VITRO CONTROL OF TISSUE DEVELOPMENT
11. Engineering Functional Tissues: In Vitro Culture Parameters 
12. Principles of Bioreactor Design for Tissue Engineering 
13. Regulation of Cell Behavior by Extracellular Proteins 
14. Cell and Matrix Dynamics in Branching Morphogenesis 
15. Mechanobiology, Tissue Development and Organ Engineering 
PART THREE: IN VIVO SYNTHESIS OF TISSUES AND ORGANS
16. In Vivo Synthesis of Tissues and Organs 
PART FOUR: BIOMATERIALS IN TISSUE ENGINEERING
17. Cell Interactions with Polymers 
18. Polymer Scaffold Fabrication 
19. Biodegradable Polymers 
20. 3D Scaffolds 
PART FIVE: TRANSPLANTATION OF ENGINEERED CELLS AND TISSUES
21. The Role of the Host Immune Response in Tissue Engineering and Regenerative Medicine 
22. Tissue Engineering and Transplantation in the Fetus 
23. in the Development of Immunoisolation Devices 
PART SIX: STEM CELLS
24. Embryonic Stem Cells 
25. Induced Pluripotent Stem Cells 
26. Neonatal Stem Cells in Tissue Engineering 
27. Embryonic Stem Cells as a Cell Source For Tissue Engineering 
28. Postnatal Stem Cells in Tissue Engineering 
PART SEVEN: GENE THERAPY
29. Gene Therapy 
30. Gene Delivery into Cells and Tissues 
PART EIGHT: BREAST
31. Breast Tissue Engineering: Reconstruction Implants and Three-Dimensional Tissue Test Systems 
PART NINE: CARDIOVASCULAR SYSTEM
32. Progenitor Cells and Cardiac Homeostasis and Regeneration 
33. Cardiac Tissue Engineering 
34. Blood Vessels 
35. Tissue-Engineering Heart Valves 
PART TEN: ENDOCRINOLOGY AND METABOLISM
36. Generation of Pancreatic Islets from Stem Cells 
37. Bioartificial Pancreas 
38. Thymus and Parathyroid Organogenesis 
PART ELEVEN: GASTROINTESTINAL SYSTEM
39. Stem Cells in the Gastrointestinal Tract 
40. Liver Stem Cells 
41. Hepatic Tissue Engineering 
PART TWELVE: HEMATOPOIETIC SYSTEM
42. Hematopoietic Stem Cells 
43. Blood Components from Pluripotent Stem Cells 
44. Red Blood Cell Substitutes 
45. Lymphoid Cells 
PART THIRTEEN: KIDNEY AND GENITOURINARY SYSTEM
46. Stem Cells in Kidney Development and Regeneration 
47. Tissue Engineering of the Kidney 
48. Bladder and Urethra 
49. Female Reproductive Organs 
50. Male Reproductive Organs 
PART FOURTEEN: MUSCULOSKELETAL SYSTEM
51. Mesenchymal Stem Cells in Musculoskeletal Tissue Engineering 
52. Bone Regeneration 
53. Tissue Engineering for Regeneration and Replacement of the Intervertebral Disc 
54. Articular Cartilage Injury 
55. Engineering Cartilage and Other Structural Tissues: Principles of Bone and Cartilage Reconstruction
56. Tendons and Ligament Tissue Engineering 
57. Skeletal Tissue Engineering 
PART FIFTEEN: NERVOUS SYSTE
58. Brain Implants 
59. Brain-Machine Interfaces 
60. Spinal Cord 
61. Protection and Repair of Hearing 
PART SIXTEEN: OPHTHALMIC
62. Stem Cells in the Eye 
63. Corneal Replacement Tissue
64. Retinal Degeneration 
65. Vision Enhancement Systems 
PART SEVENTEEN: ORAL/DENTAL APPLICATIONS
66. Biological Tooth Replacement and Repair 
67. Tissue Engineering in Oral and Maxillofacial Surgery 
68. Periodontal Tissue Engineering 
PART EIGHTEEN: RESPIRATORY SYSTEM
69. Tissue Engineering for the Respiratory Epithelium: Cell-Based Therapies for Treatment of Lung Disease 
70. Lung Tissue Engineering 
PART NINETEEN: SKIN
71. Cutaneous Epithelial Stem Cells 
72. Wound Repair: Basic Biology to Tissue Engineering 
73. Bioengineered Skin Constructs 
PART TWENTY: TISSUE-ENGINEERED FOOD
74. Principles of Tissue Engineering for Food 
75. Prospects for In Vitro Cultured Meat 
PART TWENTYONE: EMERGING TECHNOLOGIES
76. 3D Bioprinting 
77. Biofabricated 3D Tissue Models 
78. Body-on-a-Chip 
79. Monitoring and Real-Time Control of Tissue Engineered Systems 
80. Bio-Manufacturing for Regenerative Medicine 
PART TWENTYTWO: CLINICAL EXPERIENCE
81. Tissue-Engineered Skin Products 
82. Tissue-Engineered Cartilage Products 
83. Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopedic and Craniofacial Surgery 
84. Tissue-Engineered Cardiovascular Products 
85. Tissue-Engineered Organs 
PART TWENTYTHREE: REGULATION, COMMERCIALIZATION AND ETHICS
86. The Regulatory Process from Concept to Market 
87. Business Issues 
88. Ethical Issues 

Details

No. of pages:
1558
Language:
English
Copyright:
© Academic Press 2020
Published:
30th March 2020
Imprint:
Academic Press
Hardcover ISBN:
9780128184226

About the Editor

Robert Lanza

Robert Lanza

Robert Lanza, M.D. is currently Head of Astellas Global Regenerative Medicine, Chief Scientific Officer of AIRM and an adjunct professor at the Wake Forest Institute for Regenerative Medicine. Time magazine recognized him as one of the “100 Most Influential People in the World,” and Prospect magazine named him one of the Top 50 “World Thinkers.” His research focuses on stem cells and their potential to provide therapies for some of the world's most deadly and debilitating conditions. He has hundreds of scientific publications and over 30 books, including definitive references in the fields of tissue engineering and regenerative medicine. He is a former Fulbright Scholar, and studied with polio-pioneer Jonas Salk and Nobel laureates Gerald Edelman and Rodney Porter. He also worked closely (and co-authored a series of papers) with psychologist BF Skinner and heart transplant-pioneer Christiaan Barnard. Dr. Lanza received his undergraduate and medical degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. Lanza was part of the team that cloned the world’s first human embryo, the first endangered species, and published the first-ever reports of pluripotent stem cell use in humans.

Affiliations and Expertise

Astellas Institute for Regenerative Medicine, Westborough, MA, USA

Robert Langer

Robert Langer

Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies.

Affiliations and Expertise

Massachusetts Institute of Technology, Cambridge, USA

Joseph Vacanti

Dr. Joseph P. Vacanti received his M.D. degree from the university of Nebraska in 1974. He received his training in general surgery at the Massachusetts General Hospital from 1974 through 1981 and in pediatric surgery at The Children’s Hospital, Boston from 1981 through 1983. He then received clinical training in transplantation from the University of Pittsburgh. He spent two years in the laboratories of Dr. M. Judah Folkman working in the filed on angiogenesis from 1977 through 1979. Upon completion of his training, Dr. Vacanti joined the staff in surgery at children’s Hospital in Boston and began clinical programs in pediatric liver transplantation and extracorporeal membrane oxygenation. In the laboratory, he continued studies in and began work in the filed of tissue engineering in 1985. Dr. Vacanti is now John Homans Professor of Surgery at Harvard Medical School, Visiting surgeon at Massachusetts General Hospital, director of the Wellman 6 Surgical laboratories, director of the Laboratory of Tissue Engineering and Organ Fabrication and Director of Pediatric Transplantation at Massachusetts General Hospital, Boston. He has authored more than 120 original reports, 30 book chapters, and 197 abstracts. He has more than 25 patents or patents pending in the United States, Europe, and Japan.

Affiliations and Expertise

Harvard Medical School and the Massachusetts General Hospital, Boston, USA

Anthony Atala

Anthony Atala is the Director of the Wake Forest Institute for Regenerative Medicine, and the W.H. Boyce Professor and Chair of the Department of Urology at Wake Forest University. Dr. Atala is a practicing surgeon and a researcher in the area of regenerative medicine. His current work focuses on growing new human cells, tissues and organs. Dr. Atala works with several journals and serves in various roles, including Editor-in-Chief of Stem Cells- Translational Medicine, Current Stem Cell Research and Therapy, and Therapeutic Advances in Urology; as Associate Editor of Tissue Engineering and Regenerative Medicine, Rejuvenation Research, and Gene Therapy and Regulation; as Executive Board Member or Section Editor of the International Journal of Artificial Organs, Organogenesis, and Current Urology Reports; and as Editorial Board member of Expert Opinion on Biological Therapy, Biomedical Materials, Journal of Tissue Science and Engineering, 3D Printing and Additive Manufacturing, Technology, the Journal of Urology, Recent Patents on Regenerative Medicine, BioMed Central-Urology, Urology, and Current Transplantation Reports. Dr. Atala is a recipient of many awards, including the US Congress funded Christopher Columbus Foundation Award, bestowed on a living American who is currently working on a discovery that will significantly affect society, the World Technology Award in Health and Medicine, presented to individuals achieving significant and lasting progress, the Samuel D. Gross Prize, awarded every 5 years to a national leading surgical researcher by the Philadelphia Academy of Surgery, the Barringer Medal from the American Association of Genitourinary Surgeons for distinguished accomplishments, the Gold Cystoscope award from the American Urological Association for advances in the field, the Ramon Guiteras Award for pioneering research in regenerative medicine and outstanding contributions as a scholar and teacher, the Innovation Award from the Society of Manufacturing Engineers for the creation of synthetic organs, and the Rocovich Gold Medal, awarded to a distinguished scientist who has made a major impact on science toward the understanding of human disease. In 2011 he was elected to the Institute of Medicine of the National Academy of Sciences.

Affiliations and Expertise

Department of Urology, Wake Forest Institute for Regenerative Medicine, Wake Forest University, Winston-Salem, NC, USA

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